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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7595

FusionGeneSummary for CMIP_SSBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CMIP_SSBP1
Fusion gene ID: 7595
HgeneTgene
Gene symbol

CMIP

SSBP1

Gene ID

80790

6742

Gene namec-Maf inducing proteinsingle stranded DNA binding protein 1
SynonymsTCMIPMt-SSB|SOSS-B1|SSBP|mtSSB
Cytomap

16q23.2-q23.3

7q34

Type of geneprotein-codingprotein-coding
DescriptionC-Maf-inducing proteintc-Mipsingle-stranded DNA-binding protein, mitochondrialPWP1-interacting protein 17single-stranded DNA binding protein 1, mitochondrial
Modification date2018051920180523
UniProtAcc

Q8IY22

Q04837

Ensembl transtripts involved in fusion geneENST00000537098, ENST00000539778, 
ENST00000566513, ENST00000398040, 
ENST00000265304, ENST00000498107, 
ENST00000469123, ENST00000465582, 
ENST00000484178, ENST00000481508, 
Fusion gene scores* DoF score9 X 7 X 4=2525 X 5 X 2=50
# samples 105
** MAII scorelog2(10/252*10)=-1.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: CMIP [Title/Abstract] AND SSBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSSBP1

GO:0051096

positive regulation of helicase activity

12975372


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB240854CMIPchr16

81744955

-SSBP1chr7

141438215

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000537098ENST00000265304CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-5UTRENST00000537098ENST00000498107CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000537098ENST00000469123CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000537098ENST00000465582CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000537098ENST00000484178CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000537098ENST00000481508CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000539778ENST00000265304CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-5UTRENST00000539778ENST00000498107CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000539778ENST00000469123CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000539778ENST00000465582CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000539778ENST00000484178CMIPchr16

81744955

-SSBP1chr7

141438215

+
3UTR-intronENST00000539778ENST00000481508CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000566513ENST00000265304CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-5UTRENST00000566513ENST00000498107CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000566513ENST00000469123CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000566513ENST00000465582CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000566513ENST00000484178CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000566513ENST00000481508CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000398040ENST00000265304CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-5UTRENST00000398040ENST00000498107CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000398040ENST00000469123CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000398040ENST00000465582CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000398040ENST00000484178CMIPchr16

81744955

-SSBP1chr7

141438215

+
intron-intronENST00000398040ENST00000481508CMIPchr16

81744955

-SSBP1chr7

141438215

+

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FusionProtFeatures for CMIP_SSBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMIP

Q8IY22

SSBP1

Q04837

Plays a role in T-cell signaling pathway. Isoform 2 mayplay a role in T-helper 2 (Th2) signaling pathway and seems torepresent the first proximal signaling protein that links T-cellreceptor-mediated signal to the activation of c-Maf Th2 specificfactor. {ECO:0000269|PubMed:12939343,ECO:0000269|PubMed:15128042}. This protein binds preferentially and cooperatively toss-DNA. Probably involved in mitochondrial DNA replication.Associates with mitochondrial DNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CMIP_SSBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CMIP_SSBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMIP_SSBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMIP_SSBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSSBP1C0037274Dermatologic disorders1CTD_human
TgeneSSBP1C0311375Arsenic Poisoning1CTD_human