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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7576

FusionGeneSummary for CMAS_GAS5

check button Fusion gene summary
Fusion gene informationFusion gene name: CMAS_GAS5
Fusion gene ID: 7576
HgeneTgene
Gene symbol

CMAS

GAS5

Gene ID

55907

60674

Gene namecytidine monophosphate N-acetylneuraminic acid synthetasegrowth arrest specific 5
SynonymsCSSNCRNA00030|SNHG2
Cytomap

12p12.1

1q25.1

Type of geneprotein-codingncRNA
DescriptionN-acylneuraminate cytidylyltransferaseCMP-N-acetylneuraminic acid synthaseCMP-N-acetylneuraminic acid synthetaseCMP-Neu5Ac synthetaseCMP-NeuNAc synthaseCMP-NeuNAc synthetaseCMP-sialic acid synthetasecytidine 5'-monophosphate N-acetylneuraminic acidgrowth arrest specific 5 (non-protein coding)growth arrest specific transcript 5small nucleolar RNA host gene (non-protein coding) 2
Modification date2018052320180519
UniProtAcc

Q8NFW8

Ensembl transtripts involved in fusion geneENST00000229329, ENST00000363840, 
ENST00000365524, ENST00000364822, 
ENST00000363859, ENST00000385578, 
ENST00000363146, ENST00000364084, 
Fusion gene scores* DoF score3 X 3 X 2=184 X 4 X 4=64
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CMAS [Title/Abstract] AND GAS5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-G2-A3IB-01ACMASchr12

22215368

+GAS5chr1

173833442

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000229329ENST00000363840CMASchr12

22215368

+GAS5chr1

173833442

-
5CDS-intronENST00000229329ENST00000365524CMASchr12

22215368

+GAS5chr1

173833442

-
5CDS-intronENST00000229329ENST00000364822CMASchr12

22215368

+GAS5chr1

173833442

-
5CDS-intronENST00000229329ENST00000363859CMASchr12

22215368

+GAS5chr1

173833442

-
5CDS-intronENST00000229329ENST00000385578CMASchr12

22215368

+GAS5chr1

173833442

-
5CDS-intronENST00000229329ENST00000363146CMASchr12

22215368

+GAS5chr1

173833442

-
5CDS-intronENST00000229329ENST00000364084CMASchr12

22215368

+GAS5chr1

173833442

-

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FusionProtFeatures for CMAS_GAS5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CMAS

Q8NFW8

GAS5

Catalyzes the activation of N-acetylneuraminic acid(NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid(CMP-NeuNAc), a substrate required for the addition of sialicacid. Has some activity toward NeuNAc, N-glycolylneuraminic acid(Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CMAS_GAS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CMAS_GAS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CMASAPP, FBXO6, BRCA1, FGL1, LIMS1, LUC7L, DBNL, COG3, FIG4, NAA10, DDB1, NAA15, HIST1H2BG, HIST1H3A, RC3H1, CHCHD10, FAM98AGAS5TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CMAS_GAS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CMAS_GAS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGAS5C0151744Myocardial Ischemia1CTD_human