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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7566

FusionGeneSummary for CLU_RPS4X

check button Fusion gene summary
Fusion gene informationFusion gene name: CLU_RPS4X
Fusion gene ID: 7566
HgeneTgene
Gene symbol

CLU

RPS4X

Gene ID

1191

6191

Gene nameclusterinribosomal protein S4 X-linked
SynonymsAAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2CCG2|DXS306|RPS4|S4|SCAR|SCR10
Cytomap

8p21.1

Xq13.1

Type of geneprotein-codingprotein-coding
Descriptionclusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40ku70-binding protein 1sulfated glycoprotein 2testosterone-repressed prostate message 240S ribosomal protein S4, X isoformcell cycle gene 2ribosomal protein S4X isoformsingle copy abundant mRNA proteinsingle-copy abundant mRNAsmall ribosomal subunit protein eS4
Modification date2018052720180523
UniProtAcc

P10909

P62701

Ensembl transtripts involved in fusion geneENST00000316403, ENST00000546343, 
ENST00000560366, ENST00000405140, 
ENST00000523500, 
ENST00000316084, 
ENST00000486733, ENST00000373626, 
Fusion gene scores* DoF score24 X 23 X 8=44169 X 10 X 5=450
# samples 3011
** MAII scorelog2(30/4416*10)=-3.87970576628229
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLU [Title/Abstract] AND RPS4X [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLU

GO:0000902

cell morphogenesis

15857407

HgeneCLU

GO:0001774

microglial cell activation

15857407

HgeneCLU

GO:0017038

protein import

24446231

HgeneCLU

GO:0032463

negative regulation of protein homooligomerization

22179788|23106396

HgeneCLU

GO:0032464

positive regulation of protein homooligomerization

22179788

HgeneCLU

GO:0032760

positive regulation of tumor necrosis factor production

15857407

HgeneCLU

GO:0045429

positive regulation of nitric oxide biosynthetic process

15857407

HgeneCLU

GO:0050821

protein stabilization

11123922

HgeneCLU

GO:0051131

chaperone-mediated protein complex assembly

17412999

HgeneCLU

GO:0051788

response to misfolded protein

19996109

HgeneCLU

GO:0061077

chaperone-mediated protein folding

11123922

HgeneCLU

GO:0061518

microglial cell proliferation

15857407

HgeneCLU

GO:1900221

regulation of amyloid-beta clearance

24446231

HgeneCLU

GO:1901214

regulation of neuron death

17412999

HgeneCLU

GO:1901216

positive regulation of neuron death

15857407

HgeneCLU

GO:1902430

negative regulation of amyloid-beta formation

12047389|17412999

HgeneCLU

GO:1905907

negative regulation of amyloid fibril formation

22179788


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHCATCGA-DJ-A13V-01ACLUchr8

27461808

-RPS4XchrX

71493239

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000316403ENST00000316084CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-5UTRENST00000316403ENST00000486733CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-intronENST00000316403ENST00000373626CLUchr8

27461808

-RPS4XchrX

71493239

-
In-frameENST00000546343ENST00000316084CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-5UTRENST00000546343ENST00000486733CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-intronENST00000546343ENST00000373626CLUchr8

27461808

-RPS4XchrX

71493239

-
In-frameENST00000560366ENST00000316084CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-5UTRENST00000560366ENST00000486733CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-intronENST00000560366ENST00000373626CLUchr8

27461808

-RPS4XchrX

71493239

-
Frame-shiftENST00000405140ENST00000316084CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-5UTRENST00000405140ENST00000486733CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-intronENST00000405140ENST00000373626CLUchr8

27461808

-RPS4XchrX

71493239

-
In-frameENST00000523500ENST00000316084CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-5UTRENST00000523500ENST00000486733CLUchr8

27461808

-RPS4XchrX

71493239

-
5CDS-intronENST00000523500ENST00000373626CLUchr8

27461808

-RPS4XchrX

71493239

-

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FusionProtFeatures for CLU_RPS4X


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLU

P10909

RPS4X

P62701

Isoform 1 functions as extracellular chaperone thatprevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formationof amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA andaggregation-prone LYZ variants (in vitro). Does not require ATP.Maintains partially unfolded proteins in a state appropriate forsubsequent refolding by other chaperones, such as HSPA8/HSC70.Does not refold proteins by itself. Binding to cell surfacereceptors triggers internalization of the chaperone-client complexand subsequent lysosomal or proteasomal degradation. Secretedisoform 1 protects cells against apoptosis and against cytolysisby complement. Intracellular isoforms interact with ubiquitin andSCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligasecomplexes and promote the ubiquitination and subsequentproteasomal degradation of target proteins. Promotes proteasomaldegradation of COMMD1 and IKBKB. Modulates NF-kappa-Btranscriptional activity. Nuclear isoforms promote apoptosis.Mitochondrial isoforms suppress BAX-dependent release ofcytochrome c into the cytoplasm and inhibit apoptosis. Plays arole in the regulation of cell proliferation.{ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389,ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12551933,ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678,ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782,ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225,ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339,ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069,ECO:0000269|PubMed:21505792}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CLU_RPS4X


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLU_ENST00000546343_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_409aa
MEACKDSRIGGMMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKK
KKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQ
THMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMD
IHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANG

>In-frame_CLU_ENST00000560366_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_450aa
MQVCSQPQRGCVREQSAINTAPPSAHNAASPGGARGHRVPLTEACKDSRIGGMMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQG
SKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARV
CRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHF
FFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREI
LSVGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSGX

>In-frame_CLU_ENST00000523500_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_398aa
MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRE
SETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHF
SRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHP
PTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLU_ENST00000546343_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_1227nt
ATGGAGGCGTGCAAAGACTCCAGAATTGGAGGCATGATGAAGACTCTGCTGCTGTTTGTGGGGCTGCTGCTGACCTGGGAGAGTGGGCAG
GTCCTGGGGGACCAGACGGTCTCAGACAATGAGCTCCAGGAAATGTCCAATCAGGGAAGTAAGTACGTCAATAAGGAAATTCAAAATGCT
GTCAACGGGGTGAAACAGATAAAGACTCTCATAGAAAAAACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAAGAAGCCAAGAAG
AAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTC
TGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAG
CTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAG
ACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAG
CCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTG
ATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGAC
ATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGC
CACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGGTAACCTGTGTATGGTGACTGGA
GGTGCTAACCTAGGAAGAATTGGTGTGATCACCAACAGAGAGAGGCACCCTGGATCTTTTGACGTGGTTCACGTGAAAGATGCCAATGGC
AACAGCTTTGCCACTCGACTTTCCAACATTTTTGTTATTGGCAAGGGCAACAAACCATGGATTTCTCTTCCCCGAGGAAAGGGTATCCGC

>In-frame_CLU_ENST00000560366_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_1350nt
ATGCAGGTTTGCAGCCAGCCCCAAAGGGGGTGTGTGCGCGAGCAGAGCGCTATAAATACGGCGCCTCCCAGTGCCCACAACGCGGCGTCG
CCAGGAGGAGCGCGCGGGCACAGGGTGCCGCTGACCGAGGCGTGCAAAGACTCCAGAATTGGAGGCATGATGAAGACTCTGCTGCTGTTT
GTGGGGCTGCTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCAGACAATGAGCTCCAGGAAATGTCCAATCAGGGA
AGTAAGTACGTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAACAGATAAAGACTCTCATAGAAAAAACAAACGAAGAGCGCAAG
ACACTGCTCAGCAACCTAGAAGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGCTC
CCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTC
TGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGATGAATGGTGACCGC
ATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGTCCAGCATCATAGAC
GAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTC
TTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTT
GAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAATTCATACGAGAAGGC
GACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATC
TTGTCTGTGGGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCACCAACAGAGAGAGGCACCCTGGATCT
TTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACATTTTTGTTATTGGCAAGGGCAACAAACCA
TGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAAGACTGGCGGCCAAACAGAGCAGTGGGTGA

>In-frame_CLU_ENST00000523500_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_1194nt
ATGATGAAGACTCTGCTGCTGTTTGTGGGGCTGCTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCAGACAATGAG
CTCCAGGAAATGTCCAATCAGGGAAGTAAGTACGTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAACAGATAAAGACTCTCATA
GAAAAAACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAAGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAA
TCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACC
TGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTC
TACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTC
AGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGC
CTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTC
CACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCG
CCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGAC
CAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCACC
AACAGAGAGAGGCACCCTGGATCTTTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACATTTTT
GTTATTGGCAAGGGCAACAAACCATGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAAGACTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLU_ENST00000546343_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_2003nt
TCTTTGCGCCTGATTACTTCTCATGAGAGGCACTCCTTGTTAATGTGCTACTGAGTGTCCAGATGGGCCTGCTGGGCTGAGCGGGCTTTG
GATGTGAACCATTTCAGGAAGGGGAACCCCATCGTCCTGTTGGTTCTGTGATGGCAAATGGAGGCGTGCAAAGACTCCAGAATTGGAGGC
ATGATGAAGACTCTGCTGCTGTTTGTGGGGCTGCTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCAGACAATGAG
CTCCAGGAAATGTCCAATCAGGGAAGTAAGTACGTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAACAGATAAAGACTCTCATA
GAAAAAACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAAGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAA
TCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACC
TGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTC
TACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTC
AGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGC
CTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTC
CACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCG
CCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGAC
CAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCACC
AACAGAGAGAGGCACCCTGGATCTTTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACATTTTT
GTTATTGGCAAGGGCAACAAACCATGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAAGACTG
GCGGCCAAACAGAGCAGTGGGTGAAATGGGTCCCTGGGTGACATGTCAGATCTTTGTACGTAATTAAAAATATTGTGGCAGGATTAATAG
CATTTTGGTTTTGTGGGTTGTTTTTTTTTTTAATTCAGTTTCCTGCTATTTTACTGTATAACATGAACAGTGATTAAGTTCTCAGGCAGG
CTTAGGCAGTCTGTTATTGGCTGGGCTTAGTTAGTGGTGGGAAGTAGAAGATACCAGACTTGGGAAAGGAACAGCAACTAACCAAGGAGT
AGAAAGAGCCAAGAAATCCCGGAGTATTTATCTCCCCCGCCTTGACTTGGCCAAGAACTTCTCTACACAGTGGACCCCTCTGCCCTGTTA
AGTTCCCTTGGCTTTCTAAAAATCTGCCCTCATTTTCTTCTCCAGTCTGTATTGCACTAGCCCATCCACAAGCCTGGCTCATCTGTTTTT
CCCACTCCTGTGCCCATCTTGCCAAACGCAGGATGAAAATCTCCAGTTGCCATTAAAGGTGGTCATAAATGGGCTGTTGATGTTGCAAAG
CATTGCAGTTCCTTGGACTTAGTGCCCTTATTCTCCAGCTGCCGCTGCAGTCCTCAACTCTGTTTTTCAGAGGACAGAGATGTAGAACAT

>In-frame_CLU_ENST00000560366_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_2008nt
CTTTCCGCGGCATTCTTTGGGCGTGAGTCATGCAGGTTTGCAGCCAGCCCCAAAGGGGGTGTGTGCGCGAGCAGAGCGCTATAAATACGG
CGCCTCCCAGTGCCCACAACGCGGCGTCGCCAGGAGGAGCGCGCGGGCACAGGGTGCCGCTGACCGAGGCGTGCAAAGACTCCAGAATTG
GAGGCATGATGAAGACTCTGCTGCTGTTTGTGGGGCTGCTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCAGACA
ATGAGCTCCAGGAAATGTCCAATCAGGGAAGTAAGTACGTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAACAGATAAAGACTC
TCATAGAAAAAACAAACGAAGAGCGCAAGACACTGCTCAGCAACCTAGAAGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCA
GGGAATCAGAGACAAAGCTGAAGGAGCTCCCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAAC
AGACCTGCATGAAGTTCTACGCACGCGTCTGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGC
CCTTCTACTTCTGGATGAATGGTGACCGCATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACC
ACTTCAGCCGCGCGTCCAGCATCATAGACGAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCT
TCAGCCTGCCCCACCGGAGGCCTCACTTCTTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGA
ACTTCCACGCCATGTTCCAGCCCTTCCTTGAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGC
ACCCGCCAACAGAATTCATACGAGAAGGCGACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGA
AGGACCAGTGTGACAAGTGCCGGGAGATCTTGTCTGTGGGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGA
TCACCAACAGAGAGAGGCACCCTGGATCTTTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACA
TTTTTGTTATTGGCAAGGGCAACAAACCATGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAA
GACTGGCGGCCAAACAGAGCAGTGGGTGAAATGGGTCCCTGGGTGACATGTCAGATCTTTGTACGTAATTAAAAATATTGTGGCAGGATT
AATAGCATTTTGGTTTTGTGGGTTGTTTTTTTTTTTAATTCAGTTTCCTGCTATTTTACTGTATAACATGAACAGTGATTAAGTTCTCAG
GCAGGCTTAGGCAGTCTGTTATTGGCTGGGCTTAGTTAGTGGTGGGAAGTAGAAGATACCAGACTTGGGAAAGGAACAGCAACTAACCAA
GGAGTAGAAAGAGCCAAGAAATCCCGGAGTATTTATCTCCCCCGCCTTGACTTGGCCAAGAACTTCTCTACACAGTGGACCCCTCTGCCC
TGTTAAGTTCCCTTGGCTTTCTAAAAATCTGCCCTCATTTTCTTCTCCAGTCTGTATTGCACTAGCCCATCCACAAGCCTGGCTCATCTG
TTTTTCCCACTCCTGTGCCCATCTTGCCAAACGCAGGATGAAAATCTCCAGTTGCCATTAAAGGTGGTCATAAATGGGCTGTTGATGTTG
CAAAGCATTGCAGTTCCTTGGACTTAGTGCCCTTATTCTCCAGCTGCCGCTGCAGTCCTCAACTCTGTTTTTCAGAGGACAGAGATGTAG

>In-frame_CLU_ENST00000523500_chr8_27461808_-_RPS4X_ENST00000316084_chrX_71493239_-_2609nt
CATCCTTCCAAAGGGACTTTCTCTGGGAAGCCTGCTCCTCGGGCCACTGCGAACCCTCTCTACTCTCCGAAGGGAATTGTCCTTCCTGGC
TTCCACTACTTCCACCCCTGAATGCACAGGCAGCCCGGCCCAAGTCTCCCACTAGGGATGCAGATGGATTCGGTGTGAAGGGCTGGCTGC
TGTTGCCTCCGGCTCTTGAAAGTCAAGTTCAGGTGGTGCTGAGACTCCCTGGGGGCTGCAGCGCTGTGGTGAATGGGGAGCGTCTGCTGG
GGTGAAGGTTTAGGTGCACATTGCAGAGGACGTGGCTGGTCTCTGGGATGCAGTCCCTCTGTGGAGGTGGCATGGGGAGGGACGGATGCA
TGACCTAAGGGGGGTATTTTCAGTGTCTGACATGATCGATACCACTCTGGACAAGGAGGCCAGGATGCAGAAAGCCTGTGTGCCTCGCTG
ATTGTCGGGGAGGATGTGGCTTGGACAAGAGCCTGGTTCCTCCGATGCCAGGGTTCTTGTTTCTTCCACTCAACATTGCTGTCCTGCAGT
CCCTCCCTCCCTGCACCTCCTGCCTTCGCTTTCATTCGAGGTGTCCATGGCAAGTCTGGTCATTTCCCCCCATTTCCTCAGGAATAAAAG
TGCAGCAGTGCCTGCTGTGGGGACAGCTGAGGGCAGTGAGGCCCTGGGGAGCTGCTGCAGGCAGCAGGTGGGCGGGACGCCAGCAGGCTG
TCTAGCTGTTCCCATGATGGTCTCCTGTTCTCTGCAGAGGCGTGCAAAGACTCCAGAATTGGAGGCATGATGAAGACTCTGCTGCTGTTT
GTGGGGCTGCTGCTGACCTGGGAGAGTGGGCAGGTCCTGGGGGACCAGACGGTCTCAGACAATGAGCTCCAGGAAATGTCCAATCAGGGA
AGTAAGTACGTCAATAAGGAAATTCAAAATGCTGTCAACGGGGTGAAACAGATAAAGACTCTCATAGAAAAAACAAACGAAGAGCGCAAG
ACACTGCTCAGCAACCTAGAAGAAGCCAAGAAGAAGAAAGAGGATGCCCTAAATGAGACCAGGGAATCAGAGACAAAGCTGAAGGAGCTC
CCAGGAGTGTGCAATGAGACCATGATGGCCCTCTGGGAAGAGTGTAAGCCCTGCCTGAAACAGACCTGCATGAAGTTCTACGCACGCGTC
TGCAGAAGTGGCTCAGGCCTGGTTGGCCGCCAGCTTGAGGAGTTCCTGAACCAGAGCTCGCCCTTCTACTTCTGGATGAATGGTGACCGC
ATCGACTCCCTGCTGGAGAACGACCGGCAGCAGACGCACATGCTGGATGTCATGCAGGACCACTTCAGCCGCGCGTCCAGCATCATAGAC
GAGCTCTTCCAGGACAGGTTCTTCACCCGGGAGCCCCAGGATACCTACCACTACCTGCCCTTCAGCCTGCCCCACCGGAGGCCTCACTTC
TTCTTTCCCAAGTCCCGCATCGTCCGCAGCTTGATGCCCTTCTCTCCGTACGAGCCCCTGAACTTCCACGCCATGTTCCAGCCCTTCCTT
GAGATGATACACGAGGCTCAGCAGGCCATGGACATCCACTTCCATAGCCCGGCCTTCCAGCACCCGCCAACAGAATTCATACGAGAAGGC
GACGATGACCGGACTGTGTGCCGGGAGATCCGCCACAACTCCACGGGCTGCCTGCGGATGAAGGACCAGTGTGACAAGTGCCGGGAGATC
TTGTCTGTGGGTAACCTGTGTATGGTGACTGGAGGTGCTAACCTAGGAAGAATTGGTGTGATCACCAACAGAGAGAGGCACCCTGGATCT
TTTGACGTGGTTCACGTGAAAGATGCCAATGGCAACAGCTTTGCCACTCGACTTTCCAACATTTTTGTTATTGGCAAGGGCAACAAACCA
TGGATTTCTCTTCCCCGAGGAAAGGGTATCCGCCTCACCATTGCTGAAGAGAGAGACAAAAGACTGGCGGCCAAACAGAGCAGTGGGTGA
AATGGGTCCCTGGGTGACATGTCAGATCTTTGTACGTAATTAAAAATATTGTGGCAGGATTAATAGCATTTTGGTTTTGTGGGTTGTTTT
TTTTTTTAATTCAGTTTCCTGCTATTTTACTGTATAACATGAACAGTGATTAAGTTCTCAGGCAGGCTTAGGCAGTCTGTTATTGGCTGG
GCTTAGTTAGTGGTGGGAAGTAGAAGATACCAGACTTGGGAAAGGAACAGCAACTAACCAAGGAGTAGAAAGAGCCAAGAAATCCCGGAG
TATTTATCTCCCCCGCCTTGACTTGGCCAAGAACTTCTCTACACAGTGGACCCCTCTGCCCTGTTAAGTTCCCTTGGCTTTCTAAAAATC
TGCCCTCATTTTCTTCTCCAGTCTGTATTGCACTAGCCCATCCACAAGCCTGGCTCATCTGTTTTTCCCACTCCTGTGCCCATCTTGCCA
AACGCAGGATGAAAATCTCCAGTTGCCATTAAAGGTGGTCATAAATGGGCTGTTGATGTTGCAAAGCATTGCAGTTCCTTGGACTTAGTG


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FusionGenePPI for CLU_RPS4X


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLUCLU, TGFBR2, MMP25, XRCC6, C8B, C7, C9, LRP2, TGFBR1, SYVN1, H2AFX, COMMD1, NFKB1, NFKBIA, CUL1, BTRC, DISC1, TNIK, GRB2, RAD21, VHL, CHUK, TTR, BAX, CD209, XPO1, ACTN1, ZWINT, KATNA1, KNSTRN, SLC4A1, HBA1, CBY1, ELN, APP, LYZ, ATP7B, ATP7A, BCL2L1, CLUAP1, IL24, HSPD1, PRNP, PON1, FBXO6, PAXIP1, LIG4, MDC1, PDIA3, APOA1, POLR1C, BAG6, CYP2E1, MAPK9, RBBP8, KLF11, RPL23, KEAP1, TSC22D4, FOS, MDM2, CDK19, HSPA1L, NUCB2, TUBB6, TUFM, HSPA5, HSP90B1, HYOU1, UBC, EGFR, RPE, HLA-DPA1, HAX1, CCND3, DPPA4, IL20RB, SUMF2, GPR180, GINM1, SDF4, MMP3, RASSF7, TNF, RNASE13, IFNA5, PLK1, EPPIN, LTF, SEMG1, ADCYAP1R1, SRPK2, CANX, PDGFRA, ARMC6, TUBGCP5, FXR1, SETX, DOCK6, GPAM, ATG3, MAP1LC3A, MCM2, MMP9, VEGFA, SDK2, ATP2B2, PTPRS, TENM3, FAT4, FBXO27, CBWD3, KIAA0355, DHX57, ITGA8, EDEM2, MANEA, DDX31, ARHGAP36, EXTL2, TOR1A, MAN1A1, TNFSF9, PCYOX1L, PTPRF, GNB2, MAN1A2, CELSR1, NLGN2, TXNDC11, INTS5, PCYOX1, MTMR9, OCIAD1, LMAN2L, EIF3FRPS4XHNRNPH3, MCM2, ARPC3, MEPCE, RUVBL2, CDK9, ESR1, DCC, HDAC5, NOP56, RAD21, SENP3, ARRB2, SIRT7, CUL3, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, CAND1, NEDD8, RPS7, RPS8, RPS15, RPS16, RPS17, RPS19, RPS20, RPS5, RPS6, RPS9, RPS11, RPS12, RPS13, RPS18, RPS2, RPS3, RPS10, RPS21, RPS14, RPL5, RPL7, RPS3A, RPSA, RPLP0, RPL10A, RPL10, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL23A, RPL24, RPL27A, RPL31, RPL37A, RPL3, RPL6, RPL7A, RPL8, RPL9, RPS15A, RPS23, RPS24, RPS26, RPS28, RPS25, RPL4, RPL27, RPL30, RPL23, RPLP2, RPLP1, RPL22, RPL36, EEF2, RPL17, RPL32, RPS27A, EEF1A1, SLC25A5, FBL, NOP58, ILF2, SRP14, NPM1, GNL3, NCL, ILF3, HNRNPU, PABPC1, EIF3C, NOLC1, NHP2L1, EIF6, HNRNPM, LUC7L2, U2AF1, ACTA2, NAP1L1, TSR1, GAR1, HSPA8, RPL10L, RPLP0P6, HIST1H2AD, RPS27L, NOP2, PTRF, CDC5L, RRS1, HIST1H2AA, RPS10P5, SMURF1, HSP90AB1, HSP90AA1, ESR2, FN1, VCAM1, NOS2, UBL4A, ITGA4, PHB, PAN2, CD81, IGSF8, ICAM1, CTBP2, CAMK2D, FBXO6, TARDBP, EIF3CL, LARP1, RPS27, RPS29, EIF3D, EIF3L, FAU, WIBG, ZBTB1, STAU1, AURKA, AURKB, CDKN1A, CEP250, CEP57, CEP76, LGALS3BP, NEDD1, TUBG1, TUBGCP3, VCP, TP53, HUWE1, CUL7, OBSL1, CCDC8, EED, MAGEA10, ZZEF1, HECTD3, RPS6KB2, RPL29, RPL35, RPL35A, BRIX1, BYSL, DDX18, DDX24, DKC1, EIF2S3, KRR1, NOL6, RPL13A, RPL26, RPL38, RPL39, LOC101929876, SLC25A1, TUBB2B, UBA52, XRN1, NTRK1, PTEN, XPO1, AHSA1, EXOSC4, EXOSC1, GAN, SKI, TRIM29, NF2, SSSCA1, GGPS1, CYLD, TRIM25, YAP1, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLU_RPS4X


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCLUP10909DB01593ZincClusterinsmall moleculeapproved|investigational

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RelatedDiseases for CLU_RPS4X


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLUC2609414Acute kidney injury5CTD_human
HgeneCLUC0002395Alzheimer's Disease3CTD_human
HgeneCLUC0022658Kidney Diseases3CTD_human
HgeneCLUC0029408Degenerative polyarthritis2CTD_human
HgeneCLUC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCLUC0025202melanoma1CTD_human
HgeneCLUC0027686Pathologic Neovascularization1CTD_human
HgeneCLUC0033578Prostatic Neoplasms1CTD_human
HgeneCLUC0036341Schizophrenia1PSYGENET
HgeneCLUC0036572Seizures1CTD_human
HgeneCLUC0041755Adverse reaction to drug1CTD_human
HgeneCLUC0333641Atrophic1CTD_human
HgeneCLUC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCLUC3495559Juvenile arthritis1CTD_human
HgeneCLUC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneRPS4XC1458155Mammary Neoplasms1CTD_human