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Fusion gene ID: 7557 |
FusionGeneSummary for CLU_MAP2K2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLU_MAP2K2 | Fusion gene ID: 7557 | Hgene | Tgene | Gene symbol | CLU | MAP2K2 | Gene ID | 1191 | 5605 |
| Gene name | clusterin | mitogen-activated protein kinase kinase 2 | |
| Synonyms | AAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2 | CFC4|MAPKK2|MEK2|MKK2|PRKMK2 | |
| Cytomap | 8p21.1 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | clusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40ku70-binding protein 1sulfated glycoprotein 2testosterone-repressed prostate message 2 | dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P10909 | P36507 | |
| Ensembl transtripts involved in fusion gene | ENST00000316403, ENST00000546343, ENST00000560366, ENST00000405140, ENST00000523500, | ENST00000262948, ENST00000394867, ENST00000599345, | |
| Fusion gene scores | * DoF score | 24 X 23 X 8=4416 | 3 X 4 X 3=36 |
| # samples | 30 | 5 | |
| ** MAII score | log2(30/4416*10)=-3.87970576628229 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLU [Title/Abstract] AND MAP2K2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLU | GO:0000902 | cell morphogenesis | 15857407 |
| Hgene | CLU | GO:0001774 | microglial cell activation | 15857407 |
| Hgene | CLU | GO:0017038 | protein import | 24446231 |
| Hgene | CLU | GO:0032463 | negative regulation of protein homooligomerization | 22179788|23106396 |
| Hgene | CLU | GO:0032464 | positive regulation of protein homooligomerization | 22179788 |
| Hgene | CLU | GO:0032760 | positive regulation of tumor necrosis factor production | 15857407 |
| Hgene | CLU | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 15857407 |
| Hgene | CLU | GO:0050821 | protein stabilization | 11123922 |
| Hgene | CLU | GO:0051131 | chaperone-mediated protein complex assembly | 17412999 |
| Hgene | CLU | GO:0051788 | response to misfolded protein | 19996109 |
| Hgene | CLU | GO:0061077 | chaperone-mediated protein folding | 11123922 |
| Hgene | CLU | GO:0061518 | microglial cell proliferation | 15857407 |
| Hgene | CLU | GO:1900221 | regulation of amyloid-beta clearance | 24446231 |
| Hgene | CLU | GO:1901214 | regulation of neuron death | 17412999 |
| Hgene | CLU | GO:1901216 | positive regulation of neuron death | 15857407 |
| Hgene | CLU | GO:1902430 | negative regulation of amyloid-beta formation | 12047389|17412999 |
| Hgene | CLU | GO:1905907 | negative regulation of amyloid fibril formation | 22179788 |
| Tgene | MAP2K2 | GO:0036289 | peptidyl-serine autophosphorylation | 8388392 |
| Tgene | MAP2K2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF920101 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - | ||
| ChiTaRS3.1 | BF919979 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000316403 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000316403 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000316403 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000546343 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000546343 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000546343 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000560366 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000560366 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000560366 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000405140 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000405140 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000405140 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000523500 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000523500 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000523500 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102492 | - |
| intron-intron | ENST00000316403 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000316403 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000316403 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000546343 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000546343 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000546343 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000560366 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000560366 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000560366 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000405140 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000405140 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000405140 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000523500 | ENST00000262948 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000523500 | ENST00000394867 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
| intron-intron | ENST00000523500 | ENST00000599345 | CLU | chr8 | 27466480 | - | MAP2K2 | chr19 | 4102495 | - |
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FusionProtFeatures for CLU_MAP2K2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLU | MAP2K2 |
| Isoform 1 functions as extracellular chaperone thatprevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formationof amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA andaggregation-prone LYZ variants (in vitro). Does not require ATP.Maintains partially unfolded proteins in a state appropriate forsubsequent refolding by other chaperones, such as HSPA8/HSC70.Does not refold proteins by itself. Binding to cell surfacereceptors triggers internalization of the chaperone-client complexand subsequent lysosomal or proteasomal degradation. Secretedisoform 1 protects cells against apoptosis and against cytolysisby complement. Intracellular isoforms interact with ubiquitin andSCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligasecomplexes and promote the ubiquitination and subsequentproteasomal degradation of target proteins. Promotes proteasomaldegradation of COMMD1 and IKBKB. Modulates NF-kappa-Btranscriptional activity. Nuclear isoforms promote apoptosis.Mitochondrial isoforms suppress BAX-dependent release ofcytochrome c into the cytoplasm and inhibit apoptosis. Plays arole in the regulation of cell proliferation.{ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389,ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12551933,ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678,ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782,ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225,ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339,ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069,ECO:0000269|PubMed:21505792}. | Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAPkinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLU_MAP2K2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLU_MAP2K2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLU_MAP2K2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CLU | P10909 | DB01593 | Zinc | Clusterin | small molecule | approved|investigational |
| Tgene | MAP2K2 | P36507 | DB06616 | Bosutinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
| Tgene | MAP2K2 | P36507 | DB08911 | Trametinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
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RelatedDiseases for CLU_MAP2K2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CLU | C2609414 | Acute kidney injury | 5 | CTD_human |
| Hgene | CLU | C0002395 | Alzheimer's Disease | 3 | CTD_human |
| Hgene | CLU | C0022658 | Kidney Diseases | 3 | CTD_human |
| Hgene | CLU | C0029408 | Degenerative polyarthritis | 2 | CTD_human |
| Hgene | CLU | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
| Hgene | CLU | C0025202 | melanoma | 1 | CTD_human |
| Hgene | CLU | C0027686 | Pathologic Neovascularization | 1 | CTD_human |
| Hgene | CLU | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | CLU | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | CLU | C0036572 | Seizures | 1 | CTD_human |
| Hgene | CLU | C0041755 | Adverse reaction to drug | 1 | CTD_human |
| Hgene | CLU | C0333641 | Atrophic | 1 | CTD_human |
| Hgene | CLU | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| Hgene | CLU | C3495559 | Juvenile arthritis | 1 | CTD_human |
| Hgene | CLU | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
| Tgene | MAP2K2 | C3809007 | CARDIOFACIOCUTANEOUS SYNDROME 4 | 3 | UNIPROT |
| Tgene | MAP2K2 | C1275081 | Cardio-facio-cutaneous syndrome | 2 | CTD_human;ORPHANET |
| Tgene | MAP2K2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | MAP2K2 | C0025202 | melanoma | 1 | CTD_human |
| Tgene | MAP2K2 | C0028326 | Noonan Syndrome | 1 | CTD_human |
| Tgene | MAP2K2 | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |
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