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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7547

FusionGeneSummary for CLU_ADD3

check button Fusion gene summary
Fusion gene informationFusion gene name: CLU_ADD3
Fusion gene ID: 7547
HgeneTgene
Gene symbol

CLU

ADD3

Gene ID

1191

120

Gene nameclusterinadducin 3
SynonymsAAG4|APO-J|APOJ|CLI|CLU1|CLU2|KUB1|NA1/NA2|SGP-2|SGP2|SP-40|TRPM-2|TRPM2ADDL|CPSQ3
Cytomap

8p21.1

10q25.1-q25.2

Type of geneprotein-codingprotein-coding
Descriptionclusterinaging-associated protein 4apolipoprotein Jcomplement cytolysis inhibitorcomplement lysis inhibitorcomplement-associated protein SP-40,40ku70-binding protein 1sulfated glycoprotein 2testosterone-repressed prostate message 2gamma-adducinadducin 3 (gamma)adducin-like protein 70
Modification date2018052720180523
UniProtAcc

P10909

Q9UEY8

Ensembl transtripts involved in fusion geneENST00000316403, ENST00000546343, 
ENST00000560366, ENST00000405140, 
ENST00000523500, 
ENST00000360162, 
ENST00000356080, ENST00000277900, 
ENST00000497125, 
Fusion gene scores* DoF score24 X 23 X 8=44165 X 5 X 2=50
# samples 305
** MAII scorelog2(30/4416*10)=-3.87970576628229
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: CLU [Title/Abstract] AND ADD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLU

GO:0000902

cell morphogenesis

15857407

HgeneCLU

GO:0001774

microglial cell activation

15857407

HgeneCLU

GO:0017038

protein import

24446231

HgeneCLU

GO:0032463

negative regulation of protein homooligomerization

22179788|23106396

HgeneCLU

GO:0032464

positive regulation of protein homooligomerization

22179788

HgeneCLU

GO:0032760

positive regulation of tumor necrosis factor production

15857407

HgeneCLU

GO:0045429

positive regulation of nitric oxide biosynthetic process

15857407

HgeneCLU

GO:0050821

protein stabilization

11123922

HgeneCLU

GO:0051131

chaperone-mediated protein complex assembly

17412999

HgeneCLU

GO:0051788

response to misfolded protein

19996109

HgeneCLU

GO:0061077

chaperone-mediated protein folding

11123922

HgeneCLU

GO:0061518

microglial cell proliferation

15857407

HgeneCLU

GO:1900221

regulation of amyloid-beta clearance

24446231

HgeneCLU

GO:1901214

regulation of neuron death

17412999

HgeneCLU

GO:1901216

positive regulation of neuron death

15857407

HgeneCLU

GO:1902430

negative regulation of amyloid-beta formation

12047389|17412999

HgeneCLU

GO:1905907

negative regulation of amyloid fibril formation

22179788


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ719076CLUchr8

27466473

-ADD3chr10

111893082

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000316403ENST00000360162CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000316403ENST00000356080CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000316403ENST00000277900CLUchr8

27466473

-ADD3chr10

111893082

+
intron-intronENST00000316403ENST00000497125CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000546343ENST00000360162CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000546343ENST00000356080CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000546343ENST00000277900CLUchr8

27466473

-ADD3chr10

111893082

+
intron-intronENST00000546343ENST00000497125CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000560366ENST00000360162CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000560366ENST00000356080CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000560366ENST00000277900CLUchr8

27466473

-ADD3chr10

111893082

+
intron-intronENST00000560366ENST00000497125CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000405140ENST00000360162CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000405140ENST00000356080CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000405140ENST00000277900CLUchr8

27466473

-ADD3chr10

111893082

+
intron-intronENST00000405140ENST00000497125CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000523500ENST00000360162CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000523500ENST00000356080CLUchr8

27466473

-ADD3chr10

111893082

+
intron-3CDSENST00000523500ENST00000277900CLUchr8

27466473

-ADD3chr10

111893082

+
intron-intronENST00000523500ENST00000497125CLUchr8

27466473

-ADD3chr10

111893082

+

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FusionProtFeatures for CLU_ADD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLU

P10909

ADD3

Q9UEY8

Isoform 1 functions as extracellular chaperone thatprevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formationof amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA andaggregation-prone LYZ variants (in vitro). Does not require ATP.Maintains partially unfolded proteins in a state appropriate forsubsequent refolding by other chaperones, such as HSPA8/HSC70.Does not refold proteins by itself. Binding to cell surfacereceptors triggers internalization of the chaperone-client complexand subsequent lysosomal or proteasomal degradation. Secretedisoform 1 protects cells against apoptosis and against cytolysisby complement. Intracellular isoforms interact with ubiquitin andSCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligasecomplexes and promote the ubiquitination and subsequentproteasomal degradation of target proteins. Promotes proteasomaldegradation of COMMD1 and IKBKB. Modulates NF-kappa-Btranscriptional activity. Nuclear isoforms promote apoptosis.Mitochondrial isoforms suppress BAX-dependent release ofcytochrome c into the cytoplasm and inhibit apoptosis. Plays arole in the regulation of cell proliferation.{ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389,ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12551933,ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678,ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782,ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225,ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339,ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069,ECO:0000269|PubMed:21505792}. Membrane-cytoskeleton-associated protein that promotesthe assembly of the spectrin-actin network. Plays a role in actinfilament capping (PubMed:23836506). Binds to calmodulin.{ECO:0000269|PubMed:23836506}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLU_ADD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLU_ADD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLU_ADD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCLUP10909DB01593ZincClusterinsmall moleculeapproved|investigational

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RelatedDiseases for CLU_ADD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLUC2609414Acute kidney injury5CTD_human
HgeneCLUC0002395Alzheimer's Disease3CTD_human
HgeneCLUC0022658Kidney Diseases3CTD_human
HgeneCLUC0029408Degenerative polyarthritis2CTD_human
HgeneCLUC0024141Lupus Erythematosus, Systemic1CTD_human
HgeneCLUC0025202melanoma1CTD_human
HgeneCLUC0027686Pathologic Neovascularization1CTD_human
HgeneCLUC0033578Prostatic Neoplasms1CTD_human
HgeneCLUC0036341Schizophrenia1PSYGENET
HgeneCLUC0036572Seizures1CTD_human
HgeneCLUC0041755Adverse reaction to drug1CTD_human
HgeneCLUC0333641Atrophic1CTD_human
HgeneCLUC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
HgeneCLUC3495559Juvenile arthritis1CTD_human
HgeneCLUC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneADD3C0007786Brain Ischemia1CTD_human
TgeneADD3C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneADD3C0235032Neurotoxicity Syndromes1CTD_human