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Fusion gene ID: 754 |
FusionGeneSummary for ADAMTS5_CYYR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS5_CYYR1 | Fusion gene ID: 754 | Hgene | Tgene | Gene symbol | ADAMTS5 | CYYR1 | Gene ID | 11096 | 116159 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 5 | cysteine and tyrosine rich 1 | |
| Synonyms | ADAM-TS 11|ADAM-TS 5|ADAM-TS5|ADAMTS-11|ADAMTS-5|ADAMTS11|ADMP-2 | C21orf95 | |
| Cytomap | 21q21.3 | 21q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 5a disintegrin and metalloproteinase with thrombospondin motifs 11a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)aggrecanase-2 | cysteine and tyrosine-rich protein 1cysteine and tyrosine-rich protein 1 isoform 1,2,2bis,3,4cysteine and tyrosine-rich protein 1 isoform 1,2,3,4bcysteine and tyrosine-rich protein 1 isoform 1,2,3bcysteine and tyrosine-rich protein 1 isoform 1,2,4cys | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q9UNA0 | Q96J86 | |
| Ensembl transtripts involved in fusion gene | ENST00000284987, | ENST00000299340, ENST00000435845, ENST00000400043, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 5 X 4=80 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAMTS5 [Title/Abstract] AND CYYR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A6YS-01A | ADAMTS5 | chr21 | 28315699 | - | CYYR1 | chr21 | 27852748 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000284987 | ENST00000299340 | ADAMTS5 | chr21 | 28315699 | - | CYYR1 | chr21 | 27852748 | - |
| 5CDS-3UTR | ENST00000284987 | ENST00000435845 | ADAMTS5 | chr21 | 28315699 | - | CYYR1 | chr21 | 27852748 | - |
| 5CDS-3UTR | ENST00000284987 | ENST00000400043 | ADAMTS5 | chr21 | 28315699 | - | CYYR1 | chr21 | 27852748 | - |
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FusionProtFeatures for ADAMTS5_CYYR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS5 | CYYR1 |
| Metalloproteinase that plays an important role inconnective tissue organization, development, inflammation,arthritis, and cell migration. ADAMTS5 is an extracellular matrix(ECM) degrading enzyme that show proteolytic activity toward thehyalectan group of chondroitin sulfate proteoglycans (CSPGs)including aggrecan, versican, brevican and neurocan(PubMed:16133547, PubMed:18992360). Cleavage within the hyalectansoccurs at Glu-Xaa recognition motifs. Plays a role in embryonicdevelopment, including limb and cardiac morphogenesis, andskeletal muscle development through its versican remodelingproperties. Participates in development of brown adipose tissueand browning of white adipose tissue. Plays an important role forT-lymphocyte migration from draining lymph nodes following viralinfection. {ECO:0000250|UniProtKB:Q9R001,ECO:0000269|PubMed:16133547, ECO:0000269|PubMed:18992360}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAMTS5_CYYR1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAMTS5_CYYR1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADAMTS5 | CYYR1 | GOPC, MAGI1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAMTS5_CYYR1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAMTS5_CYYR1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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