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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 75

FusionGeneSummary for AATF_MPO

check button Fusion gene summary
Fusion gene informationFusion gene name: AATF_MPO
Fusion gene ID: 75
HgeneTgene
Gene symbol

AATF

MPO

Gene ID

26574

4353

Gene nameapoptosis antagonizing transcription factormyeloperoxidase
SynonymsBFR2|CHE-1|CHE1|DED-
Cytomap

17q12

17q22

Type of geneprotein-codingprotein-coding
Descriptionprotein AATFrb-binding protein Che-1myeloperoxidase
Modification date2018052320180523
UniProtAcc

Q9NY61

P05164

Ensembl transtripts involved in fusion geneENST00000225402, ENST00000590321, 
ENST00000340482, ENST00000225275, 
ENST00000578493, 
Fusion gene scores* DoF score13 X 8 X 7=72810 X 12 X 2=240
# samples 1311
** MAII scorelog2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/240*10)=-1.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AATF [Title/Abstract] AND MPO [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAATF

GO:0032929

negative regulation of superoxide anion generation

15207272

HgeneAATF

GO:0045944

positive regulation of transcription by RNA polymerase II

18049476

HgeneAATF

GO:2000378

negative regulation of reactive oxygen species metabolic process

15207272

TgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

TgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

TgeneMPO

GO:0055114

oxidation-reduction process

10772654


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF896319AATFchr17

35310287

-MPOchr17

56347897

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000225402ENST00000340482AATFchr17

35310287

-MPOchr17

56347897

+
5CDS-3UTRENST00000225402ENST00000225275AATFchr17

35310287

-MPOchr17

56347897

+
5CDS-intronENST00000225402ENST00000578493AATFchr17

35310287

-MPOchr17

56347897

+
intron-3UTRENST00000590321ENST00000340482AATFchr17

35310287

-MPOchr17

56347897

+
intron-3UTRENST00000590321ENST00000225275AATFchr17

35310287

-MPOchr17

56347897

+
intron-intronENST00000590321ENST00000578493AATFchr17

35310287

-MPOchr17

56347897

+

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FusionProtFeatures for AATF_MPO


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AATF

Q9NY61

MPO

P05164

May function as a general inhibitor of the histonedeacetylase HDAC1. Binding to the pocket region of RB1 maydisplace HDAC1 from RB1/E2F complexes, leading to activation ofE2F target genes and cell cycle progression. Conversely,displacement of HDAC1 from SP1 bound to the CDKN1A promoter leadsto increased expression of this CDK inhibitor and blocks cellcycle progression. Also antagonizes PAWR mediated induction ofaberrant amyloid peptide production in Alzheimer disease(presenile and senile dementia), although the molecular basis forthis phenomenon has not been described to date.{ECO:0000269|PubMed:12450794, ECO:0000269|PubMed:12847090,ECO:0000269|PubMed:14627703, ECO:0000269|PubMed:15207272}. Part of the host defense system of polymorphonuclearleukocytes. It is responsible for microbicidal activity against awide range of organisms. In the stimulated PMN, MPO catalyzes theproduction of hypohalous acids, primarily hypochlorous acid inphysiologic situations, and other toxic intermediates that greatlyenhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AATF_MPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AATF_MPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AATF_MPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMPOP05164DB00244MesalazineMyeloperoxidasesmall moleculeapproved
TgeneMPOP05164DB00535CefdinirMyeloperoxidasesmall moleculeapproved
TgeneMPOP05164DB00583L-CarnitineMyeloperoxidasesmall moleculeapproved|investigational
TgeneMPOP05164DB01065MelatoninMyeloperoxidasesmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for AATF_MPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMPOC0035126Reperfusion Injury6CTD_human
TgeneMPOC0021368Inflammation5CTD_human
TgeneMPOC0009324Ulcerative Colitis3CTD_human
TgeneMPOC0398595Myeloperoxidase Deficiency3CTD_human;ORPHANET;UNIPROT
TgeneMPOC0003873Rheumatoid Arthritis2CTD_human
TgeneMPOC0023891Liver Cirrhosis, Alcoholic2CTD_human
TgeneMPOC0001969Alcoholic Intoxication1PSYGENET
TgeneMPOC0002395Alzheimer's Disease1CTD_human
TgeneMPOC0005695Bladder Neoplasm1CTD_human
TgeneMPOC0006111Brain Diseases1CTD_human
TgeneMPOC0007222Cardiovascular Diseases1CTD_human
TgeneMPOC0007786Brain Ischemia1CTD_human
TgeneMPOC0009319Colitis1CTD_human
TgeneMPOC0011609Drug Eruptions1CTD_human
TgeneMPOC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneMPOC0022593Keratosis1CTD_human
TgeneMPOC0022658Kidney Diseases1CTD_human
TgeneMPOC0024115Lung diseases1CTD_human
TgeneMPOC0024121Lung Neoplasms1CTD_human
TgeneMPOC0028797Occupational Diseases1CTD_human
TgeneMPOC0030305Pancreatitis1CTD_human
TgeneMPOC0032927Precancerous Conditions1CTD_human
TgeneMPOC0033578Prostatic Neoplasms1CTD_human
TgeneMPOC0036982Shock, Hemorrhagic1CTD_human
TgeneMPOC0040954Infection by Trichuris trichiura1CTD_human
TgeneMPOC0042109Urticaria1CTD_human
TgeneMPOC0242184Hypoxia1CTD_human
TgeneMPOC0993582Arthritis, Experimental1CTD_human
TgeneMPOC1269683Major Depressive Disorder1CTD_human
TgeneMPOC2239176Liver carcinoma1CTD_human
TgeneMPOC2609414Acute kidney injury1CTD_human