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Fusion gene ID: 7493 |
FusionGeneSummary for CLPX_PARP16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLPX_PARP16 | Fusion gene ID: 7493 | Hgene | Tgene | Gene symbol | CLPX | PARP16 | Gene ID | 10845 | 54956 |
| Gene name | caseinolytic mitochondrial matrix peptidase chaperone subunit | poly(ADP-ribose) polymerase family member 16 | |
| Synonyms | - | ARTD15|C15orf30|pART15 | |
| Cytomap | 15q22.31 | 15q22.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrialClpX caseinolytic peptidase X homologClpX caseinolytic protease X homologenergy-dependent regulator of proteolysis | mono [ADP-ribose] polymerase PARP16ADP-ribosyltransferase diphtheria toxin-like 15PARP-16poly [ADP-ribose] polymerase 16 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O76031 | Q8N5Y8 | |
| Ensembl transtripts involved in fusion gene | ENST00000300107, | ENST00000261888, ENST00000444347, ENST00000558873, | |
| Fusion gene scores | * DoF score | 4 X 5 X 4=80 | 3 X 3 X 3=27 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLPX [Title/Abstract] AND PARP16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLPX | GO:0046034 | ATP metabolic process | 22710082 |
| Hgene | CLPX | GO:0051603 | proteolysis involved in cellular protein catabolic process | 16115876 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-2092-01A | CLPX | chr15 | 65440886 | - | PARP16 | chr15 | 65551735 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000300107 | ENST00000261888 | CLPX | chr15 | 65440886 | - | PARP16 | chr15 | 65551735 | - |
| intron-3UTR | ENST00000300107 | ENST00000444347 | CLPX | chr15 | 65440886 | - | PARP16 | chr15 | 65551735 | - |
| intron-intron | ENST00000300107 | ENST00000558873 | CLPX | chr15 | 65440886 | - | PARP16 | chr15 | 65551735 | - |
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FusionProtFeatures for CLPX_PARP16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLPX | PARP16 |
| ATP-dependent specificity component of the Clp proteasecomplex. Hydrolyzes ATP. Targets specific substrates fordegradation by the Clp complex (PubMed:11923310, PubMed:22710082).Can perform chaperone functions in the absence of CLPP. Enhancesthe DNA-binding activity of TFAM and is required for maintaining anormal mitochondrial nucleoid structure (PubMed:22841477). ATP-dependent unfoldase that stimulates the incorporation of thepyridoxal phosphate cofactor into 5-aminolevulinate synthase,thereby activating 5-aminolevulinate (ALA) synthesis, the firststep in heme biosynthesis. Important for efficient erythropoiesisthrough upregulation of heme biosynthesis (PubMed:25957689).{ECO:0000269|PubMed:11923310, ECO:0000269|PubMed:22710082,ECO:0000269|PubMed:22841477, ECO:0000269|PubMed:25957689}. | Intracellular mono-ADP-ribosyltransferase that may playa role in different processes through the mono-ADP-ribosylation ofproteins involved in those processes (PubMed:23103912,PubMed:22701565). May play a role in the unfolded protein response(UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, twoimportant UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor(PubMed:22701565). May not modify proteins on arginine, cysteineor glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565).{ECO:0000269|PubMed:22701565, ECO:0000269|PubMed:23103912}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLPX_PARP16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLPX_PARP16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLPX | C20orf24, CLPP, BTRC, FBXW11, BABAM1, ICT1, CUL4B, CUL1, GRB2, C1QBP, FBXO6, PARK2, RNF2, EGFR, THTPA, METTL20, LIG3, AGMAT, FASLG, GCAT, KIF12, OXLD1, LONP1, HSPE1, NTRK1, MCM2, CHCHD2, CHCHD10, PTPMT1, COQ9, CISD3, NDUFS3, TRUB2, C7orf55, COQ5, ATP5A1, PDP2, NDEL1, ATPAF2, FOXRED1, GNS, CLEC3A, TRMT1, SDHB, TRIM43, EXD2, NIT1, POLDIP2 | PARP16 | NEDD4, GMCL1, MDN1, DDX20, RAI14, LRP6, LRP5, COG6, ECSIT, VWA8, COG1, NEDD1, COG5, VAC14, B3GALNT2, LRBA, UBE4A, CRELD1, PCIF1, MRPL1, ZNF644, DOT1L, KLC4, MLKL, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLPX_PARP16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLPX_PARP16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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