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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7490

FusionGeneSummary for CLPTM1_RPS5

check button Fusion gene summary
Fusion gene informationFusion gene name: CLPTM1_RPS5
Fusion gene ID: 7490
HgeneTgene
Gene symbol

CLPTM1

RPS5

Gene ID

1209

6193

Gene nameCLPTM1, transmembrane proteinribosomal protein S5
Synonyms-S5
Cytomap

19q13.32

19q13.43

Type of geneprotein-codingprotein-coding
Descriptioncleft lip and palate transmembrane protein 1cleft lip and palate associated transmembrane protein 140S ribosomal protein S5small ribosomal subunit protein uS7
Modification date2018051920180523
UniProtAcc

O96005

P46782

Ensembl transtripts involved in fusion geneENST00000546079, ENST00000541297, 
ENST00000337392, ENST00000589158, 
ENST00000601521, ENST00000598098, 
ENST00000598495, ENST00000196551, 
ENST00000596046, 
Fusion gene scores* DoF score9 X 6 X 6=3246 X 6 X 2=72
# samples 106
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLPTM1 [Title/Abstract] AND RPS5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-05-4398-01ACLPTM1chr19

45458724

+RPS5chr19

58904726

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000546079ENST00000601521CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000546079ENST00000598098CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000546079ENST00000598495CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000546079ENST00000196551CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000546079ENST00000596046CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000541297ENST00000601521CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000541297ENST00000598098CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000541297ENST00000598495CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000541297ENST00000196551CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000541297ENST00000596046CLPTM1chr19

45458724

+RPS5chr19

58904726

+
In-frameENST00000337392ENST00000601521CLPTM1chr19

45458724

+RPS5chr19

58904726

+
In-frameENST00000337392ENST00000598098CLPTM1chr19

45458724

+RPS5chr19

58904726

+
In-frameENST00000337392ENST00000598495CLPTM1chr19

45458724

+RPS5chr19

58904726

+
In-frameENST00000337392ENST00000196551CLPTM1chr19

45458724

+RPS5chr19

58904726

+
In-frameENST00000337392ENST00000596046CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000589158ENST00000601521CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000589158ENST00000598098CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000589158ENST00000598495CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000589158ENST00000196551CLPTM1chr19

45458724

+RPS5chr19

58904726

+
intron-3CDSENST00000589158ENST00000596046CLPTM1chr19

45458724

+RPS5chr19

58904726

+

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FusionProtFeatures for CLPTM1_RPS5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLPTM1

O96005

RPS5

P46782

May play a role in T-cell development. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLPTM1_RPS5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000601521_chr19_58904726_+_123aa
MAAAQEADGARSAVVAAGGGSSGQNPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAEC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000598098_chr19_58904726_+_123aa
MAAAQEADGARSAVVAAGGGSSGQNPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAEC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000598495_chr19_58904726_+_123aa
MAAAQEADGARSAVVAAGGGSSGQNPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAEC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000196551_chr19_58904726_+_123aa
MAAAQEADGARSAVVAAGGGSSGQNPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAEC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000596046_chr19_58904726_+_123aa
MAAAQEADGARSAVVAAGGGSSGQNPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAEC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000601521_chr19_58904726_+_369nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTG
GTGAACGCCATCATCAACAGTGGTCCCCGGGAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCC
CCCCTGCGCCGTGTGAACCAGGCCATCTGGCTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGC
CTGGCAGATGAGCTCATCAATGCTGCCAAGGGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000598098_chr19_58904726_+_369nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTG
GTGAACGCCATCATCAACAGTGGTCCCCGGGAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCC
CCCCTGCGCCGTGTGAACCAGGCCATCTGGCTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGC
CTGGCAGATGAGCTCATCAATGCTGCCAAGGGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000598495_chr19_58904726_+_369nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTG
GTGAACGCCATCATCAACAGTGGTCCCCGGGAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCC
CCCCTGCGCCGTGTGAACCAGGCCATCTGGCTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGC
CTGGCAGATGAGCTCATCAATGCTGCCAAGGGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000196551_chr19_58904726_+_369nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTG
GTGAACGCCATCATCAACAGTGGTCCCCGGGAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCC
CCCCTGCGCCGTGTGAACCAGGCCATCTGGCTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGC
CTGGCAGATGAGCTCATCAATGCTGCCAAGGGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCC

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000596046_chr19_58904726_+_369nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTG
GTGAACGCCATCATCAACAGTGGTCCCCGGGAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCC
CCCCTGCGCCGTGTGAACCAGGCCATCTGGCTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGC
CTGGCAGATGAGCTCATCAATGCTGCCAAGGGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000601521_chr19_58904726_+_575nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTGGTGAACGCCATCATCAACAGTGGTCCCCGG
GAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCCCCCCTGCGCCGTGTGAACCAGGCCATCTGG
CTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGCCTGGCAGATGAGCTCATCAATGCTGCCAAG
GGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCCAACCGCTGATTTTCCCAGCTGCTGCCCAAT

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000598098_chr19_58904726_+_573nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTGGTGAACGCCATCATCAACAGTGGTCCCCGG
GAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCCCCCCTGCGCCGTGTGAACCAGGCCATCTGG
CTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGCCTGGCAGATGAGCTCATCAATGCTGCCAAG
GGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCCAACCGCTGATTTTCCCAGCTGCTGCCCAAT

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000598495_chr19_58904726_+_569nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTGGTGAACGCCATCATCAACAGTGGTCCCCGG
GAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCCCCCCTGCGCCGTGTGAACCAGGCCATCTGG
CTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGCCTGGCAGATGAGCTCATCAATGCTGCCAAG
GGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCCAACCGCTGATTTTCCCAGCTGCTGCCCAAT

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000196551_chr19_58904726_+_572nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTGGTGAACGCCATCATCAACAGTGGTCCCCGG
GAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCCCCCCTGCGCCGTGTGAACCAGGCCATCTGG
CTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGCCTGGCAGATGAGCTCATCAATGCTGCCAAG
GGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCCAACCGCTGATTTTCCCAGCTGCTGCCCAAT

>In-frame_CLPTM1_ENST00000337392_chr19_45458724_+_RPS5_ENST00000596046_chr19_58904726_+_575nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGAACCCTCTGCAGGTCCTGGTGAACGCCATCATCAACAGTGGTCCCCGG
GAGGACTCCACACGCATTGGGCGCGCCGGGACTGTGAGACGACAGGCTGTGGATGTGTCCCCCCTGCGCCGTGTGAACCAGGCCATCTGG
CTGCTGTGCACAGGCGCTCGTGAGGCTGCCTTCCGGAACATTAAGACCATTGCTGAGTGCCTGGCAGATGAGCTCATCAATGCTGCCAAG
GGCTCCTCGAACTCCTATGCCATTAAGAAGAAGGACGAGCTGGAGCGTGTGGCCAAGTCCAACCGCTGATTTTCCCAGCTGCTGCCCAAT


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FusionGenePPI for CLPTM1_RPS5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLPTM1UNC93B1, ICT1, UBAC2, ERGIC3, NTRK1, RBPJ, RNASEH2B, PARD6B, ASIC4, SCNN1D, ODF4, HTR3A, TCTN2, LMAN1, STT3B, TRIM25RPS5SRRM1, SRRM2, AGO4, RICTOR, VHL, RAD21, SIRT7, CUL3, CUL5, CDK2, CUL1, CAND1, PIK3R2, CRK, RPS4X, RPL10A, RPL12, RPL15, RPL18A, RPL18, RPL19, RPL21, RPL24, RPL30, RPL31, RPL5, RPL6, RPL7A, RPL9, RPS11, RPS13, RPS15A, RPS16, RPS19, RPS23, RPS24, RPS2, RPS3A, RPS3, RPS6, RPS8, RPSA, RPL4, RPS7, RPL11, RPL7, RPL23A, RPL14, RPS14, RPL37A, RPLP2, RPL23, RPS26, RPS12, RPLP1, RPLP0, RPL17, RPS21, RPS27A, EEF1A1, EEF2, NOP56, FBL, GNL3, DHX9, NCL, NHP2L1, TUFM, HNRNPM, HNRNPA1, EIF6, RPL10L, RPLP0P6, RBM14, SNRPA1, LOC255308, NOP2, ATP6V1B2, CA9, SMURF1, FN1, VCAM1, UBL4A, ITGA4, PAN2, NPM1, ADRB2, FBXO6, EIF3CL, GNB2L1, LARP1, NCAPD2, PNO1, RPS10, RPS20, RPS25, RPS27, RPS28, RPS29, DYNC1H1, DYNC1I2, DYNC1LI2, DYNLL1, EIF2A, EIF3L, PRUNE2, RPS18, RPS9, TSR1, WIBG, RPA3, RPA2, RPA1, AURKA, FUS, MOV10, NXF1, CUL7, HIST1H1A, NOL12, RPS6KB2, CANX, CLGN, GFM2, HBS1L, HNRNPK, KRR1, MRPL11, MRPL22, MRPL24, MRPS10, MSH2, NAT10, NOL6, POLR1A, RPL13A, RPL22, RPL27, RPL27A, RPL35, RPL38, RPL8, RPS15, LOC101929876, MRPL3, POLR1B, POLR2B, POLR2E, POLR3A, RPL10, RPL13, RPL26, RPL3, RPL35A, RPL36, SEC63, SPDL1, RRP7A, SEC61A1, SLC25A1, UBA52, WDR36, NTRK1, XPO1, HNRNPU, GAN, MCM2, NF2, RC3H1, CDC73, RRS1, ZCRB1, HIST1H1T, H2AFX, CYLD, FOXA1, HEY1, BRCA1, HDAC6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLPTM1_RPS5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneRPS5P46782DB11638Artenimol40S ribosomal protein S5small moleculeapproved|investigational

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RelatedDiseases for CLPTM1_RPS5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLPTM1C0030297Pancreatic Neoplasm1CTD_human