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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7484

FusionGeneSummary for CLPTM1_CEACAM16

check button Fusion gene summary
Fusion gene informationFusion gene name: CLPTM1_CEACAM16
Fusion gene ID: 7484
HgeneTgene
Gene symbol

CLPTM1

CEACAM16

Gene ID

1209

388551

Gene nameCLPTM1, transmembrane proteincarcinoembryonic antigen related cell adhesion molecule 16
Synonyms-CEAL2|DFNA4B
Cytomap

19q13.32

19q13.31-q13.32

Type of geneprotein-codingprotein-coding
Descriptioncleft lip and palate transmembrane protein 1cleft lip and palate associated transmembrane protein 1carcinoembryonic antigen-related cell adhesion molecule 16carcinoembryonic antigen like-2 protein
Modification date2018051920180523
UniProtAcc

O96005

Q2WEN9

Ensembl transtripts involved in fusion geneENST00000546079, ENST00000541297, 
ENST00000337392, ENST00000589158, 
ENST00000587331, ENST00000405314, 
Fusion gene scores* DoF score9 X 6 X 6=3245 X 4 X 5=100
# samples 105
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLPTM1 [Title/Abstract] AND CEACAM16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2771-01ACLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
TCGALDLUSCTCGA-66-2771-01ACLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000546079ENST00000587331CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
5UTR-3CDSENST00000546079ENST00000405314CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
In-frameENST00000541297ENST00000587331CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
In-frameENST00000541297ENST00000405314CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
In-frameENST00000337392ENST00000587331CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
In-frameENST00000337392ENST00000405314CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
intron-3CDSENST00000589158ENST00000587331CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
intron-3CDSENST00000589158ENST00000405314CLPTM1chr19

45465332

+CEACAM16chr19

45213768

+
intron-3CDSENST00000546079ENST00000587331CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000546079ENST00000405314CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000541297ENST00000587331CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000541297ENST00000405314CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000337392ENST00000587331CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000337392ENST00000405314CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000589158ENST00000587331CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+
intron-3CDSENST00000589158ENST00000405314CLPTM1chr19

45467018

+CEACAM16chr19

45213768

+

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FusionProtFeatures for CLPTM1_CEACAM16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLPTM1

O96005

CEACAM16

Q2WEN9

May play a role in T-cell development. {ECO:0000250}. Required for proper hearing, it may play a role inmaintaining the integrity of the tectorial membrane.{ECO:0000269|PubMed:21368133, ECO:0000269|PubMed:25589040}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLPTM1_CEACAM16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLPTM1_ENST00000541297_chr19_45465332_+_CEACAM16_ENST00000587331_chr19_45213768_+_51aa

>In-frame_CLPTM1_ENST00000541297_chr19_45465332_+_CEACAM16_ENST00000405314_chr19_45213768_+_51aa

>In-frame_CLPTM1_ENST00000337392_chr19_45465332_+_CEACAM16_ENST00000587331_chr19_45213768_+_65aa

>In-frame_CLPTM1_ENST00000337392_chr19_45465332_+_CEACAM16_ENST00000405314_chr19_45213768_+_65aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLPTM1_ENST00000541297_chr19_45465332_+_CEACAM16_ENST00000587331_chr19_45213768_+_154nt
ATGTCCCGAAAGGCTCATATAACCGAAAAGGTGACCAGCAATGGCAGCATCGGGAGGGACCCGCCAGCGGAGACCCAGCCTCAGAACCCA

>In-frame_CLPTM1_ENST00000541297_chr19_45465332_+_CEACAM16_ENST00000405314_chr19_45213768_+_154nt
ATGTCCCGAAAGGCTCATATAACCGAAAAGGTGACCAGCAATGGCAGCATCGGGAGGGACCCGCCAGCGGAGACCCAGCCTCAGAACCCA

>In-frame_CLPTM1_ENST00000337392_chr19_45465332_+_CEACAM16_ENST00000587331_chr19_45213768_+_196nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGGTGACCAGCAATGGCAGC
ATCGGGAGGGACCCGCCAGCGGAGACCCAGCCTCAGAACCCACCGGCCCAGCCGGCACCCAATGCCTGGCAGGTCATCAAAGGTGTGCTG

>In-frame_CLPTM1_ENST00000337392_chr19_45465332_+_CEACAM16_ENST00000405314_chr19_45213768_+_196nt
ATGGCGGCGGCGCAGGAGGCGGACGGGGCCCGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGGTGACCAGCAATGGCAGC
ATCGGGAGGGACCCGCCAGCGGAGACCCAGCCTCAGAACCCACCGGCCCAGCCGGCACCCAATGCCTGGCAGGTCATCAAAGGTGTGCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLPTM1_ENST00000541297_chr19_45465332_+_CEACAM16_ENST00000587331_chr19_45213768_+_827nt
AAACTAAGGGTCTCTCAGCAGATGGCCGGGTTTAGAGCTGTACGAAGACACACAGCTAATGAAAAATTGTGGAATTCTCAGAGCCCGTGA
AGCCTAGCCCACGGATGCGAGGTTTGGACCACTGAGGGAACGCGCATGCGTGCTAGGCAGGGCAGTCCGAAGGCTTGGGGGTGTATCATA
GGGTCTCATCGGAGGTTTGTTGGCCGTAAGACCCCTGGAATTGGAACTCTAAAAACACAGAAAGGATATGAGCTCAGGAGACTTGAACGA
AAGAGTTGTCTTAGGAAGAGGGGTCAGAAGACAAGGGTGCTGGGCAAAAGGCTAGTTCTTCGAATCAGAATACGGTGGCCAGAAAGGTTC
CTCTGACGAAAGAGGGGCGTGGTTCGAAGCCGTACAGTGGCCGGTAAAGCTCAAGAAACATGGAACGAAAAGGACGCGAAGAATCGGCAG
GGAGAAGCGGACAGGATGTCCCGAAAGGCTCATATAACCGAAAAGGTGACCAGCAATGGCAGCATCGGGAGGGACCCGCCAGCGGAGACC
CAGCCTCAGAACCCACCGGCCCAGCCGGCACCCAATGCCTGGCAGGTCATCAAAGGTGTGCTGTTTAGCCCTGGGGTAACAGCGTGACCC
TGGAGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGCGAGGATGCCAGG
CTGTGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGAGCCACCGAGGCC

>In-frame_CLPTM1_ENST00000541297_chr19_45465332_+_CEACAM16_ENST00000405314_chr19_45213768_+_827nt
AAACTAAGGGTCTCTCAGCAGATGGCCGGGTTTAGAGCTGTACGAAGACACACAGCTAATGAAAAATTGTGGAATTCTCAGAGCCCGTGA
AGCCTAGCCCACGGATGCGAGGTTTGGACCACTGAGGGAACGCGCATGCGTGCTAGGCAGGGCAGTCCGAAGGCTTGGGGGTGTATCATA
GGGTCTCATCGGAGGTTTGTTGGCCGTAAGACCCCTGGAATTGGAACTCTAAAAACACAGAAAGGATATGAGCTCAGGAGACTTGAACGA
AAGAGTTGTCTTAGGAAGAGGGGTCAGAAGACAAGGGTGCTGGGCAAAAGGCTAGTTCTTCGAATCAGAATACGGTGGCCAGAAAGGTTC
CTCTGACGAAAGAGGGGCGTGGTTCGAAGCCGTACAGTGGCCGGTAAAGCTCAAGAAACATGGAACGAAAAGGACGCGAAGAATCGGCAG
GGAGAAGCGGACAGGATGTCCCGAAAGGCTCATATAACCGAAAAGGTGACCAGCAATGGCAGCATCGGGAGGGACCCGCCAGCGGAGACC
CAGCCTCAGAACCCACCGGCCCAGCCGGCACCCAATGCCTGGCAGGTCATCAAAGGTGTGCTGTTTAGCCCTGGGGTAACAGCGTGACCC
TGGAGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGCGAGGATGCCAGG
CTGTGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGAGCCACCGAGGCC

>In-frame_CLPTM1_ENST00000337392_chr19_45465332_+_CEACAM16_ENST00000587331_chr19_45213768_+_554nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGGTGACCAGCAATGGCAGCATCGGGAGGGACCCGCCAGCGGAGACCCAG
CCTCAGAACCCACCGGCCCAGCCGGCACCCAATGCCTGGCAGGTCATCAAAGGTGTGCTGTTTAGCCCTGGGGTAACAGCGTGACCCTGG
AGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGCGAGGATGCCAGGCTG
TGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGAGCCACCGAGGCCATA

>In-frame_CLPTM1_ENST00000337392_chr19_45465332_+_CEACAM16_ENST00000405314_chr19_45213768_+_554nt
AAGTGGCCTTCCTGAGAGGCGTGGCTGCGGCACTCTTGCCGGATAGGGTGGCCCGGCGGGGCTAGGAAAGCGTGAAATCTCGCGCGATTG
CGCTGCGAAGTCGGGGACGGGGCGGGGCTGGCGGCGGGGGCGGGGACCCGGAGCGGGAAGATGGCGGCGGCGCAGGAGGCGGACGGGGCC
CGCAGCGCCGTGGTGGCGGCCGGGGGAGGCAGCTCCGGTCAGGTGACCAGCAATGGCAGCATCGGGAGGGACCCGCCAGCGGAGACCCAG
CCTCAGAACCCACCGGCCCAGCCGGCACCCAATGCCTGGCAGGTCATCAAAGGTGTGCTGTTTAGCCCTGGGGTAACAGCGTGACCCTGG
AGACGTCCAGAGAGAAGAGCTCTTCGCACCATCCTCTGGTCCTCGCCCTCTGAGTGGGAACCACTCCCCCACAGCGAGGATGCCAGGCTG
TGGTCCTGCTGTTCTCCTGCCTCCACCCTAGAGCTAGAGCCACAGGGCCCCACTCCCTCGCTGAGCTGTTGGGGAGCCACCGAGGCCATA


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FusionGenePPI for CLPTM1_CEACAM16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLPTM1UNC93B1, ICT1, UBAC2, ERGIC3, NTRK1, RBPJ, RNASEH2B, PARD6B, ASIC4, SCNN1D, ODF4, HTR3A, TCTN2, LMAN1, STT3B, TRIM25CEACAM16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLPTM1_CEACAM16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLPTM1_CEACAM16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLPTM1C0030297Pancreatic Neoplasm1CTD_human
TgeneCEACAM16C3281297DEAFNESS, AUTOSOMAL DOMINANT 4B2UNIPROT