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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7469

FusionGeneSummary for CLPB_PDE2A

check button Fusion gene summary
Fusion gene informationFusion gene name: CLPB_PDE2A
Fusion gene ID: 7469
HgeneTgene
Gene symbol

CLPB

PDE2A

Gene ID

81570

5138

Gene nameClpB homolog, mitochondrial AAA ATPase chaperoninphosphodiesterase 2A
SynonymsANKCLB|HSP78|MEGCANN|MGCA7|SKD3CGS-PDE|PDE2A1|PED2A4|cGSPDE
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
Descriptioncaseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11cGMP-dependent 3',5'-cyclic phosphodiesterasecGMP-stimulated phosphodiesterase 1cGMP-stimulated phosphodiesterase 2cGMP-stimulated phosphodiesterase 4cyclic GMP-stimulated phosphodiesterasephosphodiesterase 2A, cGMP-stimulated
Modification date2018051920180519
UniProtAcc

Q9H078

O00408

Ensembl transtripts involved in fusion geneENST00000294053, ENST00000538039, 
ENST00000437826, ENST00000340729, 
ENST00000543042, ENST00000445069, 
ENST00000538021, ENST00000542555, 
ENST00000334456, ENST00000376450, 
ENST00000444035, ENST00000544570, 
ENST00000418754, ENST00000540345, 
ENST00000540380, 
Fusion gene scores* DoF score15 X 9 X 7=9459 X 5 X 6=270
# samples 149
** MAII scorelog2(14/945*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLPB [Title/Abstract] AND PDE2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLPB

GO:0034605

cellular response to heat

2745427

TgenePDE2A

GO:0000122

negative regulation of transcription by RNA polymerase II

17329248

TgenePDE2A

GO:0006198

cAMP catabolic process

15938621|17704206

TgenePDE2A

GO:0033159

negative regulation of protein import into nucleus, translocation

17329248

TgenePDE2A

GO:0036006

cellular response to macrophage colony-stimulating factor stimulus

14687666

TgenePDE2A

GO:0043951

negative regulation of cAMP-mediated signaling

17329248

TgenePDE2A

GO:0046069

cGMP catabolic process

15938621|19828435

TgenePDE2A

GO:0071320

cellular response to cAMP

17329248

TgenePDE2A

GO:0071321

cellular response to cGMP

17704206|19828435

TgenePDE2A

GO:1904613

cellular response to 2,3,7,8-tetrachlorodibenzodioxine

17329248


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-LL-A441-01ACLPBchr11

72069924

-PDE2Achr11

72353370

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000294053ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000294053ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000294053ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000294053ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000294053ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000294053ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
5CDS-intronENST00000294053ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000538039ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000538039ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000538039ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000538039ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000538039ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000538039ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
5CDS-intronENST00000538039ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000437826ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000437826ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000437826ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000437826ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000437826ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000437826ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
5CDS-intronENST00000437826ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000340729ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000340729ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000340729ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000340729ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000340729ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000340729ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
5CDS-intronENST00000340729ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000543042ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000543042ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000543042ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000543042ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000543042ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000543042ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
5CDS-intronENST00000543042ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000445069ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000445069ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000445069ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000445069ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000445069ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
Frame-shiftENST00000445069ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
5CDS-intronENST00000445069ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000538021ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000538021ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000538021ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000538021ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000538021ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000538021ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-intronENST00000538021ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000542555ENST00000334456CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000542555ENST00000376450CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000542555ENST00000444035CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000542555ENST00000544570CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000542555ENST00000418754CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-3CDSENST00000542555ENST00000540345CLPBchr11

72069924

-PDE2Achr11

72353370

-
intron-intronENST00000542555ENST00000540380CLPBchr11

72069924

-PDE2Achr11

72353370

-

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FusionProtFeatures for CLPB_PDE2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLPB

Q9H078

PDE2A

O00408

May function as a regulatory ATPase and be related tosecretion/protein trafficking process.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLPB_PDE2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLPB_PDE2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLPBTTF2, COPS6, UCHL3, USP30, OSBPL10, TERF2, CUL3, SMAD9, MDFI, HDAC11, IRS4, CEP70, ERCC6L, TSEN2, MGEA5, NTRK1, XPO1, MCM2, NDUFA4, PTPMT1, DHRS4, COQ9, C15orf48, CISD3, C2orf47, FAM136A, OPA3, TRUB2, COQ10B, OCIAD1, ADCK3, WBSCR16, ADCK4, NDUFS3, PAK7, ADCK2, CHCHD10, C17orf89, CDKN3, CLUH, KIAA1191, PAG1, ARFIP1, SETDB1, TRIM11, MTIF2, MDM2, GTPBP10, EXOG, EIF5, NAP1L5, FBXL13PDE2AMOV10, NXF1, NUFIP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLPB_PDE2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePDE2AO00408DB08811TofisopamcGMP-dependent 3',5'-cyclic phosphodiesterasesmall moleculeapproved

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RelatedDiseases for CLPB_PDE2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLPBC42253933-METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT, AND NEUTROPENIA2ORPHANET;UNIPROT
TgenePDE2AC1458155Mammary Neoplasms1CTD_human