FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7466

FusionGeneSummary for CLPB_KIAA2026

check button Fusion gene summary
Fusion gene informationFusion gene name: CLPB_KIAA2026
Fusion gene ID: 7466
HgeneTgene
Gene symbol

CLPB

KIAA2026

Gene ID

81570

158358

Gene nameClpB homolog, mitochondrial AAA ATPase chaperoninKIAA2026
SynonymsANKCLB|HSP78|MEGCANN|MGCA7|SKD3-
Cytomap

11q13.4

9p24.1

Type of geneprotein-codingprotein-coding
Descriptioncaseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11uncharacterized protein KIAA2026
Modification date2018051920180519
UniProtAcc

Q9H078

Q5HYC2

Ensembl transtripts involved in fusion geneENST00000294053, ENST00000538039, 
ENST00000437826, ENST00000340729, 
ENST00000543042, ENST00000445069, 
ENST00000538021, ENST00000542555, 
ENST00000443149, ENST00000399933, 
ENST00000381461, 
Fusion gene scores* DoF score15 X 9 X 7=9453 X 3 X 3=27
# samples 143
** MAII scorelog2(14/945*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLPB [Title/Abstract] AND KIAA2026 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLPB

GO:0034605

cellular response to heat

2745427


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-DA-A3F3-06ACLPBchr11

72141356

-KIAA2026chr9

5881675

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000294053ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000294053ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000294053ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000538039ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000538039ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000538039ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000437826ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000437826ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000437826ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000340729ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000340729ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000340729ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
intron-intronENST00000543042ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
intron-intronENST00000543042ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
intron-intronENST00000543042ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000445069ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000445069ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5CDS-intronENST00000445069ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
intron-intronENST00000538021ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
intron-intronENST00000538021ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
intron-intronENST00000538021ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5UTR-intronENST00000542555ENST00000443149CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5UTR-intronENST00000542555ENST00000399933CLPBchr11

72141356

-KIAA2026chr9

5881675

-
5UTR-intronENST00000542555ENST00000381461CLPBchr11

72141356

-KIAA2026chr9

5881675

-

Top

FusionProtFeatures for CLPB_KIAA2026


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLPB

Q9H078

KIAA2026

Q5HYC2

May function as a regulatory ATPase and be related tosecretion/protein trafficking process.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CLPB_KIAA2026


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CLPB_KIAA2026


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLPBTTF2, COPS6, UCHL3, USP30, OSBPL10, TERF2, CUL3, SMAD9, MDFI, HDAC11, IRS4, CEP70, ERCC6L, TSEN2, MGEA5, NTRK1, XPO1, MCM2, NDUFA4, PTPMT1, DHRS4, COQ9, C15orf48, CISD3, C2orf47, FAM136A, OPA3, TRUB2, COQ10B, OCIAD1, ADCK3, WBSCR16, ADCK4, NDUFS3, PAK7, ADCK2, CHCHD10, C17orf89, CDKN3, CLUH, KIAA1191, PAG1, ARFIP1, SETDB1, TRIM11, MTIF2, MDM2, GTPBP10, EXOG, EIF5, NAP1L5, FBXL13KIAA2026CREB1, CDC42, ATXN1, UBTD1, MUS81


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CLPB_KIAA2026


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CLPB_KIAA2026


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLPBC42253933-METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT, AND NEUTROPENIA2ORPHANET;UNIPROT