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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7462

FusionGeneSummary for CLPB_CTNNA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CLPB_CTNNA2
Fusion gene ID: 7462
HgeneTgene
Gene symbol

CLPB

CTNNA2

Gene ID

81570

1496

Gene nameClpB homolog, mitochondrial AAA ATPase chaperonincatenin alpha 2
SynonymsANKCLB|HSP78|MEGCANN|MGCA7|SKD3CAP-R|CAPR|CT114|CTNR
Cytomap

11q13.4

2p12

Type of geneprotein-codingprotein-coding
Descriptioncaseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2
Modification date2018051920180522
UniProtAcc

Q9H078

P26232

Ensembl transtripts involved in fusion geneENST00000294053, ENST00000538039, 
ENST00000437826, ENST00000340729, 
ENST00000543042, ENST00000445069, 
ENST00000538021, ENST00000542555, 
ENST00000466387, ENST00000496558, 
ENST00000361291, ENST00000402739, 
ENST00000540488, ENST00000541047, 
ENST00000343114, ENST00000496251, 
ENST00000409266, 
Fusion gene scores* DoF score15 X 9 X 7=94515 X 12 X 9=1620
# samples 1415
** MAII scorelog2(14/945*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1620*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLPB [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLPB

GO:0034605

cellular response to heat

2745427


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-WB-A81R-01ACLPBchr11

72091325

-CTNNA2chr2

80620336

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000294053ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000294053ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000294053ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000294053ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000294053ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000294053ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000294053ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000294053ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000294053ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000538039ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000538039ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000538039ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000437826ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000437826ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000437826ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000340729ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000340729ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000340729ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000543042ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000543042ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000543042ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
Frame-shitENST00000445069ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000445069ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
5CDS-intronENST00000445069ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000538021ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-intronENST00000538021ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-intronENST00000538021ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000466387CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000496558CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000361291CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000402739CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000540488CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000541047CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-3CDSENST00000542555ENST00000343114CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-intronENST00000542555ENST00000496251CLPBchr11

72091325

-CTNNA2chr2

80620336

+
intron-intronENST00000542555ENST00000409266CLPBchr11

72091325

-CTNNA2chr2

80620336

+

Top

FusionProtFeatures for CLPB_CTNNA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLPB

Q9H078

CTNNA2

P26232

May function as a regulatory ATPase and be related tosecretion/protein trafficking process.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLPB_CTNNA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLPB_CTNNA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLPBTTF2, COPS6, UCHL3, USP30, OSBPL10, TERF2, CUL3, SMAD9, MDFI, HDAC11, IRS4, CEP70, ERCC6L, TSEN2, MGEA5, NTRK1, XPO1, MCM2, NDUFA4, PTPMT1, DHRS4, COQ9, C15orf48, CISD3, C2orf47, FAM136A, OPA3, TRUB2, COQ10B, OCIAD1, ADCK3, WBSCR16, ADCK4, NDUFS3, PAK7, ADCK2, CHCHD10, C17orf89, CDKN3, CLUH, KIAA1191, PAG1, ARFIP1, SETDB1, TRIM11, MTIF2, MDM2, GTPBP10, EXOG, EIF5, NAP1L5, FBXL13CTNNA2PAN2, PPP2R1A, FBXW11, CD27, UTP3, SAPCD1, CTNNB1, JUP, NTRK1, SDHAF2, GAN, MCM2, EGFR, CDH1, CDH8, CDH5, CTNNBIP1, DUSP22, FBXL5, CIR1, G3BP1, UBE2A, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CLPB_CTNNA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CLPB_CTNNA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLPBC42253933-METHYLGLUTACONIC ACIDURIA WITH CATARACTS, NEUROLOGIC INVOLVEMENT, AND NEUTROPENIA2ORPHANET;UNIPROT
TgeneCTNNA2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCTNNA2C0036341Schizophrenia1PSYGENET
TgeneCTNNA2C0038356Stomach Neoplasms1CTD_human