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Fusion gene ID: 746 |
FusionGeneSummary for ADAMTS2_C5orf60 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS2_C5orf60 | Fusion gene ID: 746 | Hgene | Tgene | Gene symbol | ADAMTS2 | C5orf60 | Gene ID | 9509 | 285679 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 2 | chromosome 5 open reading frame 60 | |
| Synonyms | ADAM-TS2|ADAMTS-2|ADAMTS-3|EDSDERMS|NPI|PC I-NP|PCI-NP|PCINP|PCPNI|PNPI | - | |
| Cytomap | 5q35.3 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 2a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2procollagen I N-proteinaseprocollagen I/II amino propeptide-processing enzymeprocollagen N-endo | putative uncharacterized protein FLJ35723 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O95450 | A6NFR6 | |
| Ensembl transtripts involved in fusion gene | ENST00000251582, ENST00000274609, | ENST00000448248, ENST00000506142, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ADAMTS2 [Title/Abstract] AND C5orf60 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-LI-A9QH-01A | ADAMTS2 | chr5 | 178699912 | - | C5orf60 | chr5 | 179070491 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000251582 | ENST00000448248 | ADAMTS2 | chr5 | 178699912 | - | C5orf60 | chr5 | 179070491 | - |
| 5CDS-5UTR | ENST00000251582 | ENST00000506142 | ADAMTS2 | chr5 | 178699912 | - | C5orf60 | chr5 | 179070491 | - |
| In-frame | ENST00000274609 | ENST00000448248 | ADAMTS2 | chr5 | 178699912 | - | C5orf60 | chr5 | 179070491 | - |
| 5CDS-5UTR | ENST00000274609 | ENST00000506142 | ADAMTS2 | chr5 | 178699912 | - | C5orf60 | chr5 | 179070491 | - |
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FusionProtFeatures for ADAMTS2_C5orf60 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS2 | C5orf60 |
| Cleaves the propeptides of type I and II collagen priorto fibril assembly. Does not act on type III collagen. May alsoplay a role in development that is independent of its role incollagen biosynthesis. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 185_188 | 229 | 1212 | Compositional bias | Note=Poly-Glu |
| Hgene | ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 40_43 | 229 | 1212 | Compositional bias | Note=Poly-Ala |
| Hgene | ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 185_188 | 229 | 567 | Compositional bias | Note=Poly-Glu |
| Hgene | ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 40_43 | 229 | 567 | Compositional bias | Note=Poly-Ala |
| Tgene | >C5orf60 | chr5:178699912 | chr5:179070491 | ENST00000448248 | - | 1 | 6 | 173_236 | 93 | 342 | Compositional bias | Note=Ser-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 618_722 | 229 | 1212 | Compositional bias | Note=Cys-rich |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 618_722 | 229 | 567 | Compositional bias | Note=Cys-rich |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 1059_1097 | 229 | 1212 | Domain | PLAC |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 266_470 | 229 | 1212 | Domain | Peptidase M12B |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 480_560 | 229 | 1212 | Domain | Note=Disintegrin |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 561_616 | 229 | 1212 | Domain | TSP type-1 1 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 854_912 | 229 | 1212 | Domain | TSP type-1 2 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 914_971 | 229 | 1212 | Domain | TSP type-1 3 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 975_1029 | 229 | 1212 | Domain | TSP type-1 4 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 1059_1097 | 229 | 567 | Domain | PLAC |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 266_470 | 229 | 567 | Domain | Peptidase M12B |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 480_560 | 229 | 567 | Domain | Note=Disintegrin |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 561_616 | 229 | 567 | Domain | TSP type-1 1 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 854_912 | 229 | 567 | Domain | TSP type-1 2 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 914_971 | 229 | 567 | Domain | TSP type-1 3 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 975_1029 | 229 | 567 | Domain | TSP type-1 4 |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 691_693 | 229 | 1212 | Motif | Cell attachment site |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 691_693 | 229 | 567 | Motif | Cell attachment site |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000251582 | - | 3 | 22 | 723_851 | 229 | 1212 | Region | Note=Spacer |
| Hgene | >ADAMTS2 | chr5:178699912 | chr5:179070491 | ENST00000274609 | - | 3 | 11 | 723_851 | 229 | 567 | Region | Note=Spacer |
| Tgene | C5orf60 | chr5:178699912 | chr5:179070491 | ENST00000448248 | - | 1 | 6 | 34_54 | 93 | 342 | Transmembrane | Helical |
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FusionGeneSequence for ADAMTS2_C5orf60 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADAMTS2_ENST00000251582_chr5_178699912_-_C5orf60_ENST00000448248_chr5_179070491_-_414aa MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAA PVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTDYRILLKELENLEIYTFLSKKCLKKLSREGSSHHLPRQVRP GPVYKPAPARNHRPRGGRGKASPTSFHVSPRAPLAPLASMPSSVPKTSVESLGSPSSLSSSKPREPLCPLKHPSHQPPASTLSPNPTSST >In-frame_ADAMTS2_ENST00000274609_chr5_178699912_-_C5orf60_ENST00000448248_chr5_179070491_-_414aa MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAA PVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTDYRILLKELENLEIYTFLSKKCLKKLSREGSSHHLPRQVRP GPVYKPAPARNHRPRGGRGKASPTSFHVSPRAPLAPLASMPSSVPKTSVESLGSPSSLSSSKPREPLCPLKHPSHQPPASTLSPNPTSST |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADAMTS2_ENST00000251582_chr5_178699912_-_C5orf60_ENST00000448248_chr5_179070491_-_1242nt ATGGATCCGCCGGCGGGAGCCGCTCGCCGCCTGCTCTGCCCCGCGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCTCCTGCCGCCG CCGCCGCCGCCCGCGAACGCCAGGCTCGCCGCCGCCGCCGACCCCCCAGGCGGGCCCCTGGGGCACGGAGCGGAGCGCATCCTGGCGGTG CCCGTGCGCACTGACGCCCAGGGCCGCTTGGTGTCCCACGTGGTGTCGGCAGCTACGTCCAGAGCAGGGGTACGAGCCCGCAGGGCCGCC CCGGTCCGGACCCCGAGCTTCCCCGGAGGCAACGAGGAGGAGCCTGGCAGTCACCTCTTCTACAATGTCACGGTCTTTGGCCGAGACCTG CACCTGCGGCTGCGGCCCAACGCCCGCCTCGTGGCGCCCGGGGCCACTATGGAGTGGCAGGGCGAGAAGGGCACCACCCGCGTGGAGCCC CTGCTCGGGAGCTGTCTCTACGTCGGAGACGTGGCCGGCCTAGCCGAAGCCTCCTCTGTGGCGCTCAGCAACTGCGATGGGCTGGCTGGT CTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTGCATGTG GTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGATTACAGAATTCTCTTGAAAGAACTGGAGAAC CTTGAGATCTACACTTTCCTGTCGAAAAAGTGCCTGAAGAAGCTCTCTAGGGAGGGCAGCTCCCATCACCTTCCACGCCAAGTCCGCCCA GGGCCAGTGTACAAACCAGCACCTGCTAGGAACCACCGGCCACGTGGGGGGCGTGGGAAAGCTTCTCCCACCAGCTTCCATGTGTCCCCA CGGGCTCCCCTGGCTCCTCTGGCCTCCATGCCGTCATCAGTCCCGAAGACCTCCGTAGAGTCCTTGGGGTCTCCATCATCCCTGAGCTCC TCCAAGCCACGAGAGCCTCTGTGTCCCCTGAAGCACCCTTCACACCAGCCACCTGCGAGCACCCTATCACCAAACCCGACCAGCTCCACA GAATCCTTGGGGGAGACCCCACATGCAGGCAGGTGGAGGCAGGGGTCCCGCTTTCCTCAGCCTGGATGTGCCAACGCTGCTGGACGCATA >In-frame_ADAMTS2_ENST00000274609_chr5_178699912_-_C5orf60_ENST00000448248_chr5_179070491_-_1242nt ATGGATCCGCCGGCGGGAGCCGCTCGCCGCCTGCTCTGCCCCGCGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCGCTCCTGCCGCCG CCGCCGCCGCCCGCGAACGCCAGGCTCGCCGCCGCCGCCGACCCCCCAGGCGGGCCCCTGGGGCACGGAGCGGAGCGCATCCTGGCGGTG CCCGTGCGCACTGACGCCCAGGGCCGCTTGGTGTCCCACGTGGTGTCGGCAGCTACGTCCAGAGCAGGGGTACGAGCCCGCAGGGCCGCC CCGGTCCGGACCCCGAGCTTCCCCGGAGGCAACGAGGAGGAGCCTGGCAGTCACCTCTTCTACAATGTCACGGTCTTTGGCCGAGACCTG CACCTGCGGCTGCGGCCCAACGCCCGCCTCGTGGCGCCCGGGGCCACTATGGAGTGGCAGGGCGAGAAGGGCACCACCCGCGTGGAGCCC CTGCTCGGGAGCTGTCTCTACGTCGGAGACGTGGCCGGCCTAGCCGAAGCCTCCTCTGTGGCGCTCAGCAACTGCGATGGGCTGGCTGGT CTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGCCGTGTGCATGTG GTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGATTACAGAATTCTCTTGAAAGAACTGGAGAAC CTTGAGATCTACACTTTCCTGTCGAAAAAGTGCCTGAAGAAGCTCTCTAGGGAGGGCAGCTCCCATCACCTTCCACGCCAAGTCCGCCCA GGGCCAGTGTACAAACCAGCACCTGCTAGGAACCACCGGCCACGTGGGGGGCGTGGGAAAGCTTCTCCCACCAGCTTCCATGTGTCCCCA CGGGCTCCCCTGGCTCCTCTGGCCTCCATGCCGTCATCAGTCCCGAAGACCTCCGTAGAGTCCTTGGGGTCTCCATCATCCCTGAGCTCC TCCAAGCCACGAGAGCCTCTGTGTCCCCTGAAGCACCCTTCACACCAGCCACCTGCGAGCACCCTATCACCAAACCCGACCAGCTCCACA GAATCCTTGGGGGAGACCCCACATGCAGGCAGGTGGAGGCAGGGGTCCCGCTTTCCTCAGCCTGGATGTGCCAACGCTGCTGGACGCATA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADAMTS2_ENST00000251582_chr5_178699912_-_C5orf60_ENST00000448248_chr5_179070491_-_1692nt AGCTGCGGGCGGCTCCAGCTGCCCCCAGATGTGGGCTGGGCGGCTCGCGGGGAACTTTCGCGCCGGCTGCGAGTGCGGGGCCCCGGCTGC AGTCCGGCTGCCATGGATCCGCCGGCGGGAGCCGCTCGCCGCCTGCTCTGCCCCGCGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCG CTCCTGCCGCCGCCGCCGCCGCCCGCGAACGCCAGGCTCGCCGCCGCCGCCGACCCCCCAGGCGGGCCCCTGGGGCACGGAGCGGAGCGC ATCCTGGCGGTGCCCGTGCGCACTGACGCCCAGGGCCGCTTGGTGTCCCACGTGGTGTCGGCAGCTACGTCCAGAGCAGGGGTACGAGCC CGCAGGGCCGCCCCGGTCCGGACCCCGAGCTTCCCCGGAGGCAACGAGGAGGAGCCTGGCAGTCACCTCTTCTACAATGTCACGGTCTTT GGCCGAGACCTGCACCTGCGGCTGCGGCCCAACGCCCGCCTCGTGGCGCCCGGGGCCACTATGGAGTGGCAGGGCGAGAAGGGCACCACC CGCGTGGAGCCCCTGCTCGGGAGCTGTCTCTACGTCGGAGACGTGGCCGGCCTAGCCGAAGCCTCCTCTGTGGCGCTCAGCAACTGCGAT GGGCTGGCTGGTCTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGC CGTGTGCATGTGGTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGATTACAGAATTCTCTTGAAA GAACTGGAGAACCTTGAGATCTACACTTTCCTGTCGAAAAAGTGCCTGAAGAAGCTCTCTAGGGAGGGCAGCTCCCATCACCTTCCACGC CAAGTCCGCCCAGGGCCAGTGTACAAACCAGCACCTGCTAGGAACCACCGGCCACGTGGGGGGCGTGGGAAAGCTTCTCCCACCAGCTTC CATGTGTCCCCACGGGCTCCCCTGGCTCCTCTGGCCTCCATGCCGTCATCAGTCCCGAAGACCTCCGTAGAGTCCTTGGGGTCTCCATCA TCCCTGAGCTCCTCCAAGCCACGAGAGCCTCTGTGTCCCCTGAAGCACCCTTCACACCAGCCACCTGCGAGCACCCTATCACCAAACCCG ACCAGCTCCACAGAATCCTTGGGGGAGACCCCACATGCAGGCAGGTGGAGGCAGGGGTCCCGCTTTCCTCAGCCTGGATGTGCCAACGCT GCTGGACGCATAAGACACCAAAATCCCAGACACTCCCATGGACACCGAATATCCGACATCCACGAACAATTGGGAATCTCCTGAGGACAA CTTGGAGATGGAGTCTCACTCTGTTGCTCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACCACAACCTCCGCCTCCCGGATTCAAGCC ATTCTCCTGCCTCAGCCTCCCGAGTAACTGGGATTACAGGCTTGTGCCACCGCACCCAGCTAATTTTTGTAATTTTAGTCGAGAGAAGGT GTCACCATGTTAGCCAGGCTTGTCTTGAACTCCTGACCTTGAGATATCTGCCCACCTCAGCCTCTCAAAGTGCTGGGATTATAGGCTTGA >In-frame_ADAMTS2_ENST00000274609_chr5_178699912_-_C5orf60_ENST00000448248_chr5_179070491_-_1692nt AGCTGCGGGCGGCTCCAGCTGCCCCCAGATGTGGGCTGGGCGGCTCGCGGGGAACTTTCGCGCCGGCTGCGAGTGCGGGGCCCCGGCTGC AGTCCGGCTGCCATGGATCCGCCGGCGGGAGCCGCTCGCCGCCTGCTCTGCCCCGCGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGCCG CTCCTGCCGCCGCCGCCGCCGCCCGCGAACGCCAGGCTCGCCGCCGCCGCCGACCCCCCAGGCGGGCCCCTGGGGCACGGAGCGGAGCGC ATCCTGGCGGTGCCCGTGCGCACTGACGCCCAGGGCCGCTTGGTGTCCCACGTGGTGTCGGCAGCTACGTCCAGAGCAGGGGTACGAGCC CGCAGGGCCGCCCCGGTCCGGACCCCGAGCTTCCCCGGAGGCAACGAGGAGGAGCCTGGCAGTCACCTCTTCTACAATGTCACGGTCTTT GGCCGAGACCTGCACCTGCGGCTGCGGCCCAACGCCCGCCTCGTGGCGCCCGGGGCCACTATGGAGTGGCAGGGCGAGAAGGGCACCACC CGCGTGGAGCCCCTGCTCGGGAGCTGTCTCTACGTCGGAGACGTGGCCGGCCTAGCCGAAGCCTCCTCTGTGGCGCTCAGCAACTGCGAT GGGCTGGCTGGTCTGATCCGGATGGAGGAGGAGGAGTTCTTCATCGAACCCTTGGAGAAGGGGCTGGCGGCGCAGGAGGCTGAGCAAGGC CGTGTGCATGTGGTGTATCGCCGGCCACCCACGTCCCCTCCTCTCGGGGGGCCACAGGCCCTGGACACAGATTACAGAATTCTCTTGAAA GAACTGGAGAACCTTGAGATCTACACTTTCCTGTCGAAAAAGTGCCTGAAGAAGCTCTCTAGGGAGGGCAGCTCCCATCACCTTCCACGC CAAGTCCGCCCAGGGCCAGTGTACAAACCAGCACCTGCTAGGAACCACCGGCCACGTGGGGGGCGTGGGAAAGCTTCTCCCACCAGCTTC CATGTGTCCCCACGGGCTCCCCTGGCTCCTCTGGCCTCCATGCCGTCATCAGTCCCGAAGACCTCCGTAGAGTCCTTGGGGTCTCCATCA TCCCTGAGCTCCTCCAAGCCACGAGAGCCTCTGTGTCCCCTGAAGCACCCTTCACACCAGCCACCTGCGAGCACCCTATCACCAAACCCG ACCAGCTCCACAGAATCCTTGGGGGAGACCCCACATGCAGGCAGGTGGAGGCAGGGGTCCCGCTTTCCTCAGCCTGGATGTGCCAACGCT GCTGGACGCATAAGACACCAAAATCCCAGACACTCCCATGGACACCGAATATCCGACATCCACGAACAATTGGGAATCTCCTGAGGACAA CTTGGAGATGGAGTCTCACTCTGTTGCTCAGGCTGGAGTGCAGTGGCACCATCTTGGCTCACCACAACCTCCGCCTCCCGGATTCAAGCC ATTCTCCTGCCTCAGCCTCCCGAGTAACTGGGATTACAGGCTTGTGCCACCGCACCCAGCTAATTTTTGTAATTTTAGTCGAGAGAAGGT GTCACCATGTTAGCCAGGCTTGTCTTGAACTCCTGACCTTGAGATATCTGCCCACCTCAGCCTCTCAAAGTGCTGGGATTATAGGCTTGA |
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FusionGenePPI for ADAMTS2_C5orf60 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADAMTS2 | PIK3R1, TAZ, CD1B, CLEC12A, SUSD4, IDS, B3GNT2, LIPH, PRG2, TMPRSS11B, DKKL1, ST8SIA4, SLAMF1, TCTN2, LYPD4, ADAM2, ADAMTS4, ADAM30 | C5orf60 | KRT31, GMCL1, KRTAP3-2, KRT40, KRTAP10-9, NOTCH2NL |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAMTS2_C5orf60 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAMTS2_C5orf60 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADAMTS2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
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