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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7436

FusionGeneSummary for CLMN_WDR20

check button Fusion gene summary
Fusion gene informationFusion gene name: CLMN_WDR20
Fusion gene ID: 7436
HgeneTgene
Gene symbol

CLMN

WDR20

Gene ID

79789

91833

Gene namecalminWD repeat domain 20
Synonyms-DMR
Cytomap

14q32.13

14q32.31

Type of geneprotein-codingprotein-coding
Descriptioncalmincalmin (calponin-like, transmembrane)calponin-like transmembrane domain proteinWD repeat-containing protein 20
Modification date2018052320180519
UniProtAcc

Q96JQ2

Q8TBZ3

Ensembl transtripts involved in fusion geneENST00000298912, ENST00000557215, 
ENST00000556441, 		ENST00000335263, 
ENST00000424963, ENST00000322340, 
ENST00000499851, ENST00000342702, 
ENST00000556807, ENST00000558567, 
ENST00000299135, ENST00000454394, 
ENST00000556511, ENST00000557186, 
ENST00000545563, 
Fusion gene scores* DoF score5 X 2 X 5=504 X 3 X 5=60
# samples 55
** MAII scorelog2(5/50*10)=0log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLMN [Title/Abstract] AND WDR20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-G2-AA3D-01ACLMNchr14

95786048

-WDR20chr14

102689167

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000298912ENST00000335263CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000424963CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000322340CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000499851CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000342702CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000556807CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000558567CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000299135CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000454394CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000556511CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000557186CLMNchr14

95786048

-WDR20chr14

102689167

+
5CDS-intronENST00000298912ENST00000545563CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-3CDSENST00000557215ENST00000335263CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000424963CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000322340CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000499851CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000342702CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000556807CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000558567CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000299135CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000454394CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000556511CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000557186CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000557215ENST00000545563CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-3CDSENST00000556441ENST00000335263CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000424963CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000322340CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000499851CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000342702CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000556807CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000558567CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000299135CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000454394CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000556511CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000557186CLMNchr14

95786048

-WDR20chr14

102689167

+
intron-intronENST00000556441ENST00000545563CLMNchr14

95786048

-WDR20chr14

102689167

+

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FusionProtFeatures for CLMN_WDR20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLMN

Q96JQ2

WDR20

Q8TBZ3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLMN_WDR20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLMN_WDR20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLMNPPP1CC, CDH1, TCTEX1D2WDR20COL11A2, PDHA1, PKN2, SURF2, YWHAB, YWHAH, POLR1C, OPTN, UBXN1, FBXW5, WDR48, USP12, USP46, PHLPP2, PHLPP1, UBL4A, USP12P1, LIG4, YWHAQ, ZDHHC17, TYK2, VSX1, MRM1, VSX2, DAPP1, TMEM17, XPO1, HSP90AA1, AR, FERMT2, TSPYL6, RNF19B, TRIM35, C15orf27, HSPB8, USH1C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CLMN_WDR20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLMN_WDR20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource