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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7430

FusionGeneSummary for CLK4_ATP2C1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK4_ATP2C1
Fusion gene ID: 7430
HgeneTgene
Gene symbol

CLK4

ATP2C1

Gene ID

57396

27032

Gene nameCDC like kinase 4ATPase secretory pathway Ca2+ transporting 1
Synonyms-ATP2C1A|BCPM|HHD|PMR1|SPCA1|hSPCA1
Cytomap

5q35.3

3q22.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase CLK4protein serine threonine kinase Clk4calcium-transporting ATPase type 2C member 1ATP-dependent Ca(2+) pump PMR1ATPase 2C1ATPase, Ca(2+)-sequesteringATPase, Ca++ transporting, type 2C, member 1HUSSY-28secretory pathway Ca2+/Mn2+ ATPase 1
Modification date2018051920180523
UniProtAcc

Q9HAZ1

P98194

Ensembl transtripts involved in fusion geneENST00000316308, ENST00000522749, 
ENST00000520957, 		ENST00000505330, 
ENST00000504381, ENST00000507488, 
ENST00000393221, ENST00000533801, 
ENST00000510168, ENST00000508532, 
ENST00000504948, ENST00000513801, 
ENST00000328560, ENST00000428331, 
ENST00000359644, ENST00000422190, 
ENST00000509150, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 3=108
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLK4 [Title/Abstract] AND ATP2C1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATP2C1

GO:0006816

calcium ion transport

12810057

TgeneATP2C1

GO:0006874

cellular calcium ion homeostasis

12810057


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE698743CLK4chr5

178043544

+ATP2C1chr3

130699208

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000316308ENST00000505330CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000504381CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000507488CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000393221CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000533801CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000510168CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000508532CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000504948CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000513801CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000328560CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000428331CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000359644CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000422190CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000316308ENST00000509150CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000505330CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000504381CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000507488CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000393221CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000533801CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000510168CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000508532CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000504948CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000513801CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000328560CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000428331CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000359644CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000422190CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000522749ENST00000509150CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000505330CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000504381CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000507488CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000393221CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000533801CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000510168CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000508532CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000504948CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000513801CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000328560CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000428331CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000359644CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000422190CLK4chr5

178043544

+ATP2C1chr3

130699208

-
intron-intronENST00000520957ENST00000509150CLK4chr5

178043544

+ATP2C1chr3

130699208

-

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FusionProtFeatures for CLK4_ATP2C1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK4

Q9HAZ1

ATP2C1

P98194

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex and may bea constituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3.Required for the regulation of alternative splicing of MAPT/TAU.Regulates the alternative splicing of tissue factor (F3) pre-mRNAin endothelial cells. {ECO:0000269|PubMed:11170754,ECO:0000269|PubMed:19168442}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLK4_ATP2C1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLK4_ATP2C1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLK4_ATP2C1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneATP2C1P98194DB01189DesfluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved
TgeneATP2C1P98194DB00228EnfluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|investigational|vet_approved
TgeneATP2C1P98194DB01028MethoxyfluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|investigational|vet_approved
TgeneATP2C1P98194DB01373CalciumCalcium-transporting ATPase type 2C member 1small moleculeapproved|nutraceutical
TgeneATP2C1P98194DB00753IsofluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|vet_approved
TgeneATP2C1P98194DB01159HalothaneCalcium-transporting ATPase type 2C member 1small moleculeapproved|vet_approved
TgeneATP2C1P98194DB01236SevofluraneCalcium-transporting ATPase type 2C member 1small moleculeapproved|vet_approved

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RelatedDiseases for CLK4_ATP2C1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneATP2C1C0085106Familial benign pemphigus7CTD_human;ORPHANET;UNIPROT