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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7428

FusionGeneSummary for CLK3_ITIH4

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK3_ITIH4
Fusion gene ID: 7428
HgeneTgene
Gene symbol

CLK3

ITIH4

Gene ID

1198

3700

Gene nameCDC like kinase 3inter-alpha-trypsin inhibitor heavy chain family member 4
SynonymsPHCLK3|PHCLK3/152GP120|H4P|IHRP|ITI-HC4|ITIHL1|PK-120|PK120
Cytomap

15q24.1

3p21.1

Type of geneprotein-codingprotein-coding
Descriptiondual specificity protein kinase CLK3inter-alpha-trypsin inhibitor heavy chain H4ITI heavy chain H4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)inter-alpha-inhibitor heavy chain 4inter-alpha-trypsin inhibitor family heavy chain-related proteininter-alpha
Modification date2018052220180519
UniProtAcc

P49761

Q14624

Ensembl transtripts involved in fusion geneENST00000564353, ENST00000345005, 
ENST00000395066, ENST00000348245, 
ENST00000352989, 		ENST00000266041, 
ENST00000346281, ENST00000485816, 
ENST00000406595, ENST00000434759, 
ENST00000467462, 
Fusion gene scores* DoF score2 X 2 X 1=45 X 5 X 2=50
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/50*10)=0
Context

PubMed: CLK3 [Title/Abstract] AND ITIH4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLK3

GO:0006468

protein phosphorylation

9637771

HgeneCLK3

GO:0043484

regulation of RNA splicing

9637771


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI133372CLK3chr15

74891910

+ITIH4chr3

52851061

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000564353ENST00000266041CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000564353ENST00000346281CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000564353ENST00000485816CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000564353ENST00000406595CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000564353ENST00000434759CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000564353ENST00000467462CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000345005ENST00000266041CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000345005ENST00000346281CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000345005ENST00000485816CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000345005ENST00000406595CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000345005ENST00000434759CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000345005ENST00000467462CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000395066ENST00000266041CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000395066ENST00000346281CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000395066ENST00000485816CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000395066ENST00000406595CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000395066ENST00000434759CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000395066ENST00000467462CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000348245ENST00000266041CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000348245ENST00000346281CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000348245ENST00000485816CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000348245ENST00000406595CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000348245ENST00000434759CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000348245ENST00000467462CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000352989ENST00000266041CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000352989ENST00000346281CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000352989ENST00000485816CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-3CDSENST00000352989ENST00000406595CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000352989ENST00000434759CLK3chr15

74891910

+ITIH4chr3

52851061

-
intron-intronENST00000352989ENST00000467462CLK3chr15

74891910

+ITIH4chr3

52851061

-

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FusionProtFeatures for CLK3_ITIH4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK3

P49761

ITIH4

Q14624

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicingof tissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:19168442, ECO:0000269|PubMed:9637771}. Type II acute-phase protein (APP) involved ininflammatory responses to trauma. May also play a role in liverdevelopment or regeneration. {ECO:0000269|PubMed:19263524}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLK3_ITIH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLK3_ITIH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLK3_ITIH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneITIH4Q14624DB01593ZincInter-alpha-trypsin inhibitor heavy chain H4small moleculeapproved|investigational

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RelatedDiseases for CLK3_ITIH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneITIH4C0005586Bipolar Disorder3PSYGENET
TgeneITIH4C0009375Colonic Neoplasms1CTD_human
TgeneITIH4C0032580Adenomatous Polyposis Coli1CTD_human