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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7426

FusionGeneSummary for CLK2_MARS

check button Fusion gene summary
Fusion gene informationFusion gene name: CLK2_MARS
Fusion gene ID: 7426
HgeneTgene
Gene symbol

CLK2

MARS

Gene ID

9894

84174

Gene nametelomere maintenance 2Src like adaptor 2
SynonymsCLK2|TEL2|YHFSC20orf156|MARS|SLAP-2|SLAP2
Cytomap

16p13.3

20q11.23

Type of geneprotein-codingprotein-coding
Descriptiontelomere length regulation protein TEL2 homologTEL2, telomere maintenance 2, homologprotein clk-2 homologsrc-like-adapter 2Src-like adapter protein-2modulator of antigen receptor signaling
Modification date2018052320180523
UniProtAcc

P49760

P56192

Ensembl transtripts involved in fusion geneENST00000361168, ENST00000368361, 
ENST00000355560, ENST00000497188, 
ENST00000536801, 
ENST00000262027, 
ENST00000315473, ENST00000447721, 
Fusion gene scores* DoF score5 X 5 X 5=12511 X 11 X 4=484
# samples 515
** MAII scorelog2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/484*10)=-1.69004454677871
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLK2 [Title/Abstract] AND MARS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMARS

GO:0000122

negative regulation of transcription by RNA polymerase II

11696592

TgeneMARS

GO:0050849

negative regulation of calcium-mediated signaling

11696592


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-FX-A2QS-01ACLK2chr1

155238084

-MARSchr12

57881813

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361168ENST00000262027CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000361168ENST00000315473CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000361168ENST00000447721CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-5UTRENST00000368361ENST00000262027CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000368361ENST00000315473CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000368361ENST00000447721CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-5UTRENST00000355560ENST00000262027CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000355560ENST00000315473CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000355560ENST00000447721CLK2chr1

155238084

-MARSchr12

57881813

+
5UTR-5UTRENST00000497188ENST00000262027CLK2chr1

155238084

-MARSchr12

57881813

+
5UTR-intronENST00000497188ENST00000315473CLK2chr1

155238084

-MARSchr12

57881813

+
5UTR-intronENST00000497188ENST00000447721CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-5UTRENST00000536801ENST00000262027CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000536801ENST00000315473CLK2chr1

155238084

-MARSchr12

57881813

+
5CDS-intronENST00000536801ENST00000447721CLK2chr1

155238084

-MARSchr12

57881813

+

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FusionProtFeatures for CLK2_MARS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLK2

P49760

MARS

P56192

Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex. May be aconstituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing and can cause redistribution ofSR proteins from speckles to a diffuse nucleoplasmic distribution.Acts as a suppressor of hepatic gluconeogenesis and glucose outputby repressing PPARGC1A transcriptional activity on gluconeogenicgenes via its phosphorylation. Phosphorylates PPP2R5B therebystimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1complex leading to dephosphorylation of AKT1. Phosphorylates:PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing oftissue factor (F3) pre-mRNA in endothelial cells.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442,ECO:0000269|PubMed:8910305, ECO:0000269|PubMed:9637771}. Catalyzes the specific attachment of an amino acid toits cognate tRNA in a 2 step reaction: the amino acid (AA) isfirst activated by ATP to form AA-AMP and then transferred to theacceptor end of the tRNA. {ECO:0000269|PubMed:11714285}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLK2_MARS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLK2_MARS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLK2CLK3, UBL5, FANCM, C19orf40, YWHAG, HSP90AA1, AKT1, SNRNP70, PNN, HNRNPM, LUC7L, TNPO3, CLK2, HUWE1, PSME3, SKIV2L2, ZCCHC8, BCLAF1, CPSF1, FIP1L1, RBBP6, WDR33, PPHLN1, RBM7, ACIN1, PABPC1, SETD2, PKP2, THRAP3, CPSF2, RBM39, SON, ZNF30, HNRNPF, CPSF4, CDKN2A, ECE1, TRIM27, SDCBP, SRPK2, U2AF1, UBE2I, ZRSR2, ZNF263, SRRM1, RNPS1, KLHL2, ZNF473, MRPL4, LUZP4, RSRP1, ZNF398, GMCL1, SNIP1, CPSF7, ZNF394, LNX1, PRPF38A, YTHDC1, BRCA1, EED, TRA2A, LUC7L2, TBC1D9B, NKTR, ZC3H18, CLK1, RBMXL1, SRSF8, ELAVL2, CLASRP, GPATCH8, ZNF638, C11orf57, SRSF12, MDK, SRSF10, NCOA5, EPB41L2, RSBN1L, C17orf85, GPALPP1, APOBEC3D, U2AF2, CDX1, ZC3H14, GSPT2, REPIN1, SRRT, JPH4, CASC3, PRPF4B, PTPN1MARSMCC, GIPC1, PRKAB1, ILK, BRF2, MYC, HDAC5, RPS27, TNNT1, CDK9, FBXO25, CUL3, CUL1, IARS, DARS, AIMP1, QARS, EPRS, LARS, KARS, RARS, AIMP2, EEF1E1, ACAT1, CCT3, FN1, VCAM1, ITGA4, EGFR, CASK, FBXO6, EIF2S1, RPL13, RPL27A, RPLP0, HUWE1, CUL7, CCDC8, RNF2, ESR1, SDCBP, EEA1, GARS, GFPT1, HARS, CIAPIN1, HK2, HSP90B1, PIN4, RCC2, XPNPEP1, NAA20, NMT1, OXSR1, TRMT6, TRMT61A, TXLNA, VARS, NTRK1, PKN2, CRY1, CRY2, MCM2, LENG1, ZNF746, CYLD, COQ2, DLST, PDHA1, FOXA1, G3BP1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLK2_MARS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLK2_MARS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMARSC4084821CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2U2ORPHANET;UNIPROT
TgeneMARSC4225400INTERSTITIAL LUNG AND LIVER DISEASE2ORPHANET;UNIPROT