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Fusion gene ID: 7421 |
FusionGeneSummary for CLK1_ORC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLK1_ORC2 | Fusion gene ID: 7421 | Hgene | Tgene | Gene symbol | CLK1 | ORC2 | Gene ID | 78989 | 4999 |
| Gene name | collectin subfamily member 11 | origin recognition complex subunit 2 | |
| Synonyms | 3MC2|CL-K1-I|CL-K1-II|CL-K1-IIa|CL-K1-IIb|CLK1 | ORC2L | |
| Cytomap | 2p25.3 | 2q33.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collectin-11Collectin K1collectin kidney protein 1collectin sub-family member 11 | origin recognition complex subunit 2origin recognition complex protein 2 homologorigin recognition complex, subunit 2 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P49759 | Q13416 | |
| Ensembl transtripts involved in fusion gene | ENST00000321356, ENST00000409769, ENST00000434813, ENST00000492793, | ENST00000234296, ENST00000467605, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 2 X 3=18 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLK1 [Title/Abstract] AND ORC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-D7-6527-01A | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000321356 | ENST00000234296 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| 5UTR-intron | ENST00000321356 | ENST00000467605 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| intron-3CDS | ENST00000409769 | ENST00000234296 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| intron-intron | ENST00000409769 | ENST00000467605 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| intron-3CDS | ENST00000434813 | ENST00000234296 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| intron-intron | ENST00000434813 | ENST00000467605 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| 5UTR-3CDS | ENST00000492793 | ENST00000234296 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
| 5UTR-intron | ENST00000492793 | ENST00000467605 | CLK1 | chr2 | 201729287 | - | ORC2 | chr2 | 201778715 | - |
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FusionProtFeatures for CLK1_ORC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLK1 | ORC2 |
| Dual specificity kinase acting on both serine/threonineand tyrosine-containing substrates. Phosphorylates serine- andarginine-rich (SR) proteins of the spliceosomal complex and may bea constituent of a network of regulatory mechanisms that enable SRproteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 andPTPN1. Regulates the alternative splicing of tissue factor (F3)pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.{ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. | Component of the origin recognition complex (ORC) thatbinds origins of replication. DNA-binding is ATP-dependent. Thespecific DNA sequences that define origins of replication have notbeen identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Bindshistone H3 and H4 trimethylation marks H3K9me3, H3K20me3 andH4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.{ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLK1_ORC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLK1_ORC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLK1 | BCLAF1, NCOR1, SRSF3, SAFB, UBL5, SRSF1, LUC7L3, YWHAG, ISG15, PIAS4, BAG3, SRPK2, SRPK1, PRMT5, PDE9A, KRTAP10-7, TRA2A, PRPF4B, ABCA13, ACOX2, ANKFY1, ARHGEF12, ARPC4, ASL, ASXL3, ATP10A, ATP4A, C1orf94, C3orf67, ELP6, MTCL1, CDCP1, CDH23, CDK12, CELSR3, CENPE, CEP95, CKAP5, CLASRP, CLK1, COCH, CRNKL1, CTNND2, CUL3, CWC27, CYP46A1, DBR1, DENND4A, DNAJC13, DNAJC24, DPYD, DSC2, ECE1, MICU3, ENO1, FAM132B, FAM160B2, FAM189A1, FAT1, FBF1, GEMIN5, GRM6, GSDMB, HADH, HIST1H2BK, HIVEP1, HNMT, HNRNPA0, HNRNPA1, HNRNPA3, HRASLS5, HSP90AB2P, HSPBP1, HTATSF1, IMPDH2, IP6K1, ITGA5, KATNA1, KHDRBS1, ICE1, KIF14, KIF23, KRT8, LINS, LMNA, MAP7, MFSD10, MKRN2, KIAA1804, MTBP, MYOM1, NCL, NF1, NPM1, NUP153, PATZ1, PHF3, PHLDB2, PIP4K2B, PKD1L1, PLXDC2, PPFIBP2, PPHLN1, PPIG, PPP1CB, PRDX5, PRKDC, PRPF38A, PTPN22, RAD21L1, RAPH1, RASL12, RBBP6, RBM15, RBM39, RBMX, REV1, RLF, RPL5, RPS4Y1, RPUSD3, SAMD9L, SCARA3, SERPINI2, SF3B1, SFMBT2, SRSF5, SRSF6, SRSF7, SHROOM1, SLC35D3, SLFN5, SPEN, SPTBN4, SRRM1, SRRM2, SSBP3, STIP1, STK31, SVOP, TEX11, THRAP3, THY1, TJP2, TLN2, TMPO, TMPRSS2, TNIP2, TP53RK, TRA2B, UNC13B, VWA7, WDR66, YTHDC1, ZC3H13, ZC3H18, ZMYND10, ZNF148, KLC1, PSEN2, SYMPK, AKAP5, SMEK1, CLK2 | ORC2 | MCM2, MCM7, RPA1, RPA2, CDC6, DBF4, CDC45, ORC1, ORC2, ORC3, ORC4, ORC5, MCM4, MCM5, MCM6, ORC6, XRCC5, BRCA1, CCNA2, CDK2, MCM10, MCM3, MCM8, TERF2, KAT7, CCL2, CBX5, HMGA1, XRCC6, RAD18, LRWD1, NUCKS1, CDC5L, CDT1, LMNA, FXR1, HIST3H3, HIST4H4, ILF2, SIRT2, OBFC1, EP300, CDC42BPB, RABGAP1, PES1, KIF11, RBM8A, PARD6A, BRINP1, NFATC1, TEAD2, FOXE1, FOXG1, FOXL1, FOXM1, FOXQ1, FOXS1, SNW1, RPGR |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLK1_ORC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLK1_ORC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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