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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7410

FusionGeneSummary for CLIP1_ZCCHC8

check button Fusion gene summary
Fusion gene informationFusion gene name: CLIP1_ZCCHC8
Fusion gene ID: 7410
HgeneTgene
Gene symbol

CLIP1

ZCCHC8

Gene ID

6249

55596

Gene nameCAP-Gly domain containing linker protein 1zinc finger CCHC-type containing 8
SynonymsCLIP|CLIP-170|CLIP170|CYLN1|RSN-
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionCAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)zinc finger CCHC domain-containing protein 8TRAMP-like complex RNA-binding factor ZCCHC8zinc finger, CCHC domain containing 8
Modification date2018052220180519
UniProtAcc

P30622

Q6NZY4

Ensembl transtripts involved in fusion geneENST00000361654, ENST00000545889, 
ENST00000302528, ENST00000358808, 
ENST00000537178, ENST00000540338, 
ENST00000536634, ENST00000540539, 
ENST00000536306, ENST00000543897, 
ENST00000336229, ENST00000538116, 
Fusion gene scores* DoF score11 X 12 X 9=11884 X 5 X 5=100
# samples 167
** MAII scorelog2(16/1188*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLIP1 [Title/Abstract] AND ZCCHC8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-ZF-AA51-01ACLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
TCGARVCESCTCGA-ZJ-AAXN-01ACLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
TCGARVHNSCTCGA-P3-A6T7-01ACLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000361654ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000361654ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000361654ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-intronENST00000361654ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000545889ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000545889ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000545889ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-intronENST00000545889ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000302528ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000302528ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000302528ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-intronENST00000302528ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000358808ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000358808ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000358808ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-intronENST00000358808ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000537178ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000537178ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-5UTRENST00000537178ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-intronENST00000537178ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000540338ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000540338ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000540338ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-intronENST00000540338ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000536634ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000536634ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000536634ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-intronENST00000536634ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000540539ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000540539ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-5UTRENST00000540539ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
intron-intronENST00000540539ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122967242

-
5UTR-3CDSENST00000361654ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000361654ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000361654ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000361654ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000545889ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000545889ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000545889ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000545889ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000302528ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000302528ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000302528ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000302528ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000358808ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000358808ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000358808ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000358808ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000537178ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000537178ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000537178ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5UTR-3CDSENST00000537178ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540338ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540338ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540338ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540338ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000536634ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000536634ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000536634ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000536634ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540539ENST00000536306CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540539ENST00000543897CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540539ENST00000336229CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
intron-3CDSENST00000540539ENST00000538116CLIP1chr12

122907068

-ZCCHC8chr12

122958822

-
5CDS-intronENST00000361654ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000361654ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000361654ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000361654ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-intronENST00000545889ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-5UTRENST00000545889ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-5UTRENST00000545889ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-intronENST00000545889ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000302528ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000302528ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000302528ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000302528ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000358808ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000358808ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000358808ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000358808ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000537178ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000537178ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000537178ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000537178ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000540338ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000540338ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-5UTRENST00000540338ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
5CDS-intronENST00000540338ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-intronENST00000536634ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-5UTRENST00000536634ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-5UTRENST00000536634ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-intronENST00000536634ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-intronENST00000540539ENST00000536306CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-5UTRENST00000540539ENST00000543897CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-5UTRENST00000540539ENST00000336229CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-
intron-intronENST00000540539ENST00000538116CLIP1chr12

122861936

-ZCCHC8chr12

122968110

-

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FusionProtFeatures for CLIP1_ZCCHC8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLIP1

P30622

ZCCHC8

Q6NZY4

Binds to the plus end of microtubules and regulates thedynamics of the microtubule cytoskeleton. Promotes microtubulegrowth and microtubule bundling. Links cytoplasmic vesicles tomicrotubules and thereby plays an important role in intracellularvesicle trafficking. Plays a role macropinocytosis and endosometrafficking. {ECO:0000269|PubMed:12433698,ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}. Scaffolding subunit of the trimeric nuclear exosometargeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosomeis fundamental for the degradation of RNA in eukaryotic nuclei.Substrate targeting is facilitated by its cofactor MTREX, whichlinks to RNA-binding protein adapters (PubMed:27871484). May beinvolved in pre-mRNA splicing (Probable).{ECO:0000269|PubMed:27871484, ECO:0000305|PubMed:16263084}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLIP1_ZCCHC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLIP1_ZCCHC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLIP1MTOR, IQGAP1, CDC42, RAC1, PAFAH1B1, CALM1, BIN1, MAPRE1, TUBA1A, TUBB, AMOT, BUB3, MAEA, PSMC2, HDAC6, CADPS, CHD4, GPS1, DCTN1, DYNC1H1, PCGF1, DPPA4, NANOG, POU5F1, TSC22D2, GORASP1, BMP1, DAB2IP, RUNDC3A, BRCA1ZCCHC8BRCA1, PPP2R1A, PPP2R2D, PPP2R2B, SIRT7, SKIV2L2, RBM7, CUL3, APP, U2AF1, THOC6, THOC1, U2AF2, USP7, PSMC2, MICB, TXNDC9, PSMA1, PSMC5, USP28, ZC3H15, PSMD13, PSMC4, PSMB6, PRPF40A, SOX2, CLK2, YWHAB, RPA3, RPA2, RPA1, DROSHA, RNF2, BMI1, RBM11, EXOSC3, EXOSC7, EXOSC8, RBM4B, LUC7L, PPP2R2C, INPPL1, NTRK1, XPO1, GBA, RET, SNCA, NCBP2, ZC3H18, C1D, HNRNPF, EXOSC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLIP1_ZCCHC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLIP1_ZCCHC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZCCHC8C3714756Intellectual Disability1CTD_human