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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7402

FusionGeneSummary for CLIP1_DPP9

check button Fusion gene summary
Fusion gene informationFusion gene name: CLIP1_DPP9
Fusion gene ID: 7402
HgeneTgene
Gene symbol

CLIP1

DPP9

Gene ID

6249

91039

Gene nameCAP-Gly domain containing linker protein 1dipeptidyl peptidase 9
SynonymsCLIP|CLIP-170|CLIP170|CYLN1|RSNDP9|DPLP9|DPRP-2|DPRP2
Cytomap

12q24.31

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionCAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)dipeptidyl peptidase 9DPP IXdipeptidyl peptidase IV-related protein-2dipeptidyl peptidase IXdipeptidyl peptidase-like protein 9dipeptidylpeptidase 9
Modification date2018052220180520
UniProtAcc

P30622

Q86TI2

Ensembl transtripts involved in fusion geneENST00000361654, ENST00000545889, 
ENST00000302528, ENST00000358808, 
ENST00000537178, ENST00000540338, 
ENST00000536634, ENST00000540539, 
ENST00000262960, ENST00000598800, 
ENST00000597849, ENST00000594671, 
ENST00000601173, 
Fusion gene scores* DoF score11 X 12 X 9=11884 X 5 X 2=40
# samples 165
** MAII scorelog2(16/1188*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLIP1 [Title/Abstract] AND DPP9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF369453CLIP1chr12

122876563

+DPP9chr19

4717257

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000361654ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000361654ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000361654ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000361654ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000361654ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000545889ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000545889ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000545889ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000545889ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000545889ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000302528ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000302528ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000302528ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000302528ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000302528ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000358808ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000358808ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000358808ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000358808ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000358808ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000537178ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000537178ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000537178ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000537178ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000537178ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540338ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540338ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540338ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540338ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540338ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000536634ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000536634ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000536634ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000536634ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000536634ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540539ENST00000262960CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540539ENST00000598800CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540539ENST00000597849CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540539ENST00000594671CLIP1chr12

122876563

+DPP9chr19

4717257

-
intron-intronENST00000540539ENST00000601173CLIP1chr12

122876563

+DPP9chr19

4717257

-

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FusionProtFeatures for CLIP1_DPP9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLIP1

P30622

DPP9

Q86TI2

Binds to the plus end of microtubules and regulates thedynamics of the microtubule cytoskeleton. Promotes microtubulegrowth and microtubule bundling. Links cytoplasmic vesicles tomicrotubules and thereby plays an important role in intracellularvesicle trafficking. Plays a role macropinocytosis and endosometrafficking. {ECO:0000269|PubMed:12433698,ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLIP1_DPP9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLIP1_DPP9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLIP1_DPP9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLIP1_DPP9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDPP9C1800706Idiopathic Pulmonary Fibrosis1CTD_human;ORPHANET