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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7397

FusionGeneSummary for CLINT1_CLINT1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLINT1_CLINT1
Fusion gene ID: 7397
HgeneTgene
Gene symbol

CLINT1

CLINT1

Gene ID

9685

9685

Gene nameclathrin interactor 1clathrin interactor 1
SynonymsCLINT|ENTH|EPN4|EPNRCLINT|ENTH|EPN4|EPNR
Cytomap

5q33.3

5q33.3

Type of geneprotein-codingprotein-coding
Descriptionclathrin interactor 1clathrin interacting protein localized in the trans-Golgi regionenthoprotinepsin 4epsin-related proteinepsinRclathrin interactor 1clathrin interacting protein localized in the trans-Golgi regionenthoprotinepsin 4epsin-related proteinepsinR
Modification date2018052220180522
UniProtAcc

Q14677

Q14677

Ensembl transtripts involved in fusion geneENST00000523094, ENST00000530742, 
ENST00000296951, ENST00000411809, 
ENST00000523908, 		ENST00000523094, 
ENST00000530742, ENST00000296951, 
ENST00000411809, ENST00000523908, 
Fusion gene scores* DoF score3 X 4 X 2=244 X 5 X 2=40
# samples 45
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLINT1 [Title/Abstract] AND CLINT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CV350256CLINT1chr5

157245910

-CLINT1chr5

157245782

+
ChiTaRS3.1AW993884CLINT1chr5

157270382

+CLINT1chr5

157269494

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000523094ENST00000523094CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523094ENST00000530742CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523094ENST00000296951CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523094ENST00000411809CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523094ENST00000523908CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000530742ENST00000523094CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000530742ENST00000530742CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000530742ENST00000296951CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000530742ENST00000411809CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000530742ENST00000523908CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000296951ENST00000523094CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000296951ENST00000530742CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000296951ENST00000296951CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000296951ENST00000411809CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000296951ENST00000523908CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000411809ENST00000523094CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000411809ENST00000530742CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000411809ENST00000296951CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000411809ENST00000411809CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000411809ENST00000523908CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523908ENST00000523094CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523908ENST00000530742CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523908ENST00000296951CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523908ENST00000411809CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523908ENST00000523908CLINT1chr5

157245910

-CLINT1chr5

157245782

+
intron-intronENST00000523094ENST00000523094CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523094ENST00000530742CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523094ENST00000296951CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523094ENST00000411809CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523094ENST00000523908CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000530742ENST00000523094CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000530742ENST00000530742CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000530742ENST00000296951CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000530742ENST00000411809CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000530742ENST00000523908CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000296951ENST00000523094CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000296951ENST00000530742CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000296951ENST00000296951CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000296951ENST00000411809CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000296951ENST00000523908CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000411809ENST00000523094CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000411809ENST00000530742CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000411809ENST00000296951CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000411809ENST00000411809CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000411809ENST00000523908CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523908ENST00000523094CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523908ENST00000530742CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523908ENST00000296951CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523908ENST00000411809CLINT1chr5

157270382

+CLINT1chr5

157269494

+
intron-intronENST00000523908ENST00000523908CLINT1chr5

157270382

+CLINT1chr5

157269494

+

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FusionProtFeatures for CLINT1_CLINT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLINT1

Q14677

CLINT1

Q14677

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport viaclathrin-coated vesicles from the trans-Golgi network toendosomes. Stimulates clathrin assembly.{ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport viaclathrin-coated vesicles from the trans-Golgi network toendosomes. Stimulates clathrin assembly.{ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLINT1_CLINT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLINT1_CLINT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLINT1_CLINT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLINT1_CLINT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource