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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7393

FusionGeneSummary for CLIC5_CLIC5

check button Fusion gene summary
Fusion gene informationFusion gene name: CLIC5_CLIC5
Fusion gene ID: 7393
HgeneTgene
Gene symbol

CLIC5

CLIC5

Gene ID

53405

53405

Gene namechloride intracellular channel 5chloride intracellular channel 5
SynonymsDFNB102|DFNB103|MST130|MSTP130DFNB102|DFNB103|MST130|MSTP130
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptionchloride intracellular channel protein 5chloride intracellular channel protein 5
Modification date2018051920180519
UniProtAcc

Q9NZA1

Q9NZA1

Ensembl transtripts involved in fusion geneENST00000339561, ENST00000185206, 
ENST00000544153, ENST00000486570, 
ENST00000339561, ENST00000185206, 
ENST00000544153, ENST00000486570, 
Fusion gene scores* DoF score2 X 3 X 2=122 X 3 X 2=12
# samples 55
** MAII scorelog2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLIC5 [Title/Abstract] AND CLIC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLIC5

GO:0006821

chloride transport

10793131

TgeneCLIC5

GO:0006821

chloride transport

10793131


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI056690CLIC5chr6

45933315

-CLIC5chr6

45934143

-
ChiTaRS3.1BI056842CLIC5chr6

45934143

+CLIC5chr6

45933315

+
ChiTaRS3.1BI057718CLIC5chr6

45933315

-CLIC5chr6

45934143

-
ChiTaRS3.1BI057689CLIC5chr6

45934143

+CLIC5chr6

45933315

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000339561ENST00000339561CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000339561ENST00000185206CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000339561ENST00000544153CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000339561ENST00000486570CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000185206ENST00000339561CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000185206ENST00000185206CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000185206ENST00000544153CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000185206ENST00000486570CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000544153ENST00000339561CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000544153ENST00000185206CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000544153ENST00000544153CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000544153ENST00000486570CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000486570ENST00000339561CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000486570ENST00000185206CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000486570ENST00000544153CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000486570ENST00000486570CLIC5chr6

45933315

-CLIC5chr6

45934143

-
intron-intronENST00000339561ENST00000339561CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000339561ENST00000185206CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000339561ENST00000544153CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000339561ENST00000486570CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000185206ENST00000339561CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000185206ENST00000185206CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000185206ENST00000544153CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000185206ENST00000486570CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000544153ENST00000339561CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000544153ENST00000185206CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000544153ENST00000544153CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000544153ENST00000486570CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000486570ENST00000339561CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000486570ENST00000185206CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000486570ENST00000544153CLIC5chr6

45934143

+CLIC5chr6

45933315

+
intron-intronENST00000486570ENST00000486570CLIC5chr6

45934143

+CLIC5chr6

45933315

+

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FusionProtFeatures for CLIC5_CLIC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLIC5

Q9NZA1

CLIC5

Q9NZA1

Required for normal hearing (PubMed:24781754). It isnecessary for the formation of stereocilia in the inner ear andnormal development of the organ of Corti (By similarity). Caninsert into membranes and form poorly selective ion channels thatmay also transport chloride ions. May play a role in theregulation of transepithelial ion absorption and secretion. Isrequired for the development and/or maintenance of the properglomerular endothelial cell and podocyte architecture(PubMed:15184393, PubMed:18028448, PubMed:20335315).{ECO:0000250|UniProtKB:Q8BXK9, ECO:0000269|PubMed:15184393,ECO:0000269|PubMed:18028448, ECO:0000269|PubMed:20335315,ECO:0000269|PubMed:24781754}. Required for normal hearing (PubMed:24781754). It isnecessary for the formation of stereocilia in the inner ear andnormal development of the organ of Corti (By similarity). Caninsert into membranes and form poorly selective ion channels thatmay also transport chloride ions. May play a role in theregulation of transepithelial ion absorption and secretion. Isrequired for the development and/or maintenance of the properglomerular endothelial cell and podocyte architecture(PubMed:15184393, PubMed:18028448, PubMed:20335315).{ECO:0000250|UniProtKB:Q8BXK9, ECO:0000269|PubMed:15184393,ECO:0000269|PubMed:18028448, ECO:0000269|PubMed:20335315,ECO:0000269|PubMed:24781754}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLIC5_CLIC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLIC5_CLIC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLIC5_CLIC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLIC5_CLIC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource