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Fusion gene ID: 7389 |
FusionGeneSummary for CLIC4_RCAN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLIC4_RCAN3 | Fusion gene ID: 7389 | Hgene | Tgene | Gene symbol | CLIC4 | RCAN3 | Gene ID | 25932 | 11123 |
| Gene name | chloride intracellular channel 4 | RCAN family member 3 | |
| Synonyms | CLIC4L|H1|MTCLIC|huH1|p64H1 | DSCR1L2|MCIP3|RCN3|hRCN3 | |
| Cytomap | 1p36.11 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chloride intracellular channel protein 4chloride intracellular channel 4 likeintracellular chloride ion channel protein p64H1 | calcipressin-3Down syndrome candidate region 1-like 2Down syndrome critical region gene 1-like 2down syndrome candidate region 1-like protein 2myocyte-enriched calcineurin-interacting protein 3regulator of calcineurin 3 isoform 1b,2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y696 | Q9UKA8 | |
| Ensembl transtripts involved in fusion gene | ENST00000374379, ENST00000497755, | ENST00000436717, ENST00000374395, ENST00000412742, ENST00000538532, ENST00000374393, | |
| Fusion gene scores | * DoF score | 9 X 3 X 7=189 | 1 X 1 X 1=1 |
| # samples | 8 | 1 | |
| ** MAII score | log2(8/189*10)=-1.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CLIC4 [Title/Abstract] AND RCAN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLIC4 | GO:0030336 | negative regulation of cell migration | 12163372 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-PG-A914-01A | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374379 | ENST00000436717 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| In-frame | ENST00000374379 | ENST00000374395 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| In-frame | ENST00000374379 | ENST00000412742 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 5CDS-intron | ENST00000374379 | ENST00000538532 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 5CDS-intron | ENST00000374379 | ENST00000374393 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 3UTR-3CDS | ENST00000497755 | ENST00000436717 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 3UTR-3CDS | ENST00000497755 | ENST00000374395 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 3UTR-3CDS | ENST00000497755 | ENST00000412742 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 3UTR-intron | ENST00000497755 | ENST00000538532 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
| 3UTR-intron | ENST00000497755 | ENST00000374393 | CLIC4 | chr1 | 25072116 | + | RCAN3 | chr1 | 24857708 | + |
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FusionProtFeatures for CLIC4_RCAN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLIC4 | RCAN3 |
| Can insert into membranes and form poorly selective ionchannels that may also transport chloride ions. Channel activitydepends on the pH. Membrane insertion seems to be redox-regulatedand may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions likea potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.Could also promote endothelial cell proliferation and regulateendothelial morphogenesis (tubulogenesis).{ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596,ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224,ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >RCAN3 | chr1:25072116 | chr1:24857708 | ENST00000374393 | + | 0 | 2 | 183_203 | 0 | 116 | Region | Calcineurin-binding |
| Tgene | >RCAN3 | chr1:25072116 | chr1:24857708 | ENST00000374395 | + | 1 | 5 | 183_203 | 65 | 242 | Region | Calcineurin-binding |
| Tgene | >RCAN3 | chr1:25072116 | chr1:24857708 | ENST00000412742 | + | 0 | 3 | 183_203 | 65 | 174 | Region | Calcineurin-binding |
| Tgene | >RCAN3 | chr1:25072116 | chr1:24857708 | ENST00000436717 | + | 1 | 5 | 183_203 | 65 | 232 | Region | Calcineurin-binding |
| Tgene | >RCAN3 | chr1:25072116 | chr1:24857708 | ENST00000538532 | + | 0 | 3 | 183_203 | -9 | 184 | Region | Calcineurin-binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CLIC4 | chr1:25072116 | chr1:24857708 | ENST00000374379 | + | 1 | 6 | 104_244 | 24 | 254 | Domain | Note=GST C-terminal |
| Hgene | >CLIC4 | chr1:25072116 | chr1:24857708 | ENST00000374379 | + | 1 | 6 | 2_101 | 24 | 254 | Region | Required for insertion into the membrane |
| Hgene | >CLIC4 | chr1:25072116 | chr1:24857708 | ENST00000374379 | + | 1 | 6 | 37_57 | 24 | 254 | Transmembrane | Helical%3B Note%3DAfter insertion into the membrane |
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FusionGeneSequence for CLIC4_RCAN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000436717_chr1_24857708_+_191aa MALSMPLNGLKEEDKEPLIELFVKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQSYLLPPQP VKQFLISPPASPPVGWKQSEDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKIAQTRRPDPPTAAL >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000374395_chr1_24857708_+_201aa MALSMPLNGLKEEDKEPLIELFVKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQVQMSGEVR DKSYLLPPQPVKQFLISPPASPPVGWKQSEDAMPVINYDLLCAVSKLGPGEKYELHAGTESTPSVVVHVCESETEEEEETKNPKQKIAQT >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000412742_chr1_24857708_+_133aa MALSMPLNGLKEEDKEPLIELFVKERFEALFTIYDDQVTFQLFKSFRRVRINFSKPEAAARARIELHETDFNGQKLKLYFAQERNMNFTR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000436717_chr1_24857708_+_573nt ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGAAAGATTTGAAGCACTC TTCACCATCTATGATGACCAGGTTACTTTTCAGCTGTTTAAAAGCTTTAGAAGAGTCAGAATAAATTTCAGCAAACCTGAAGCGGCAGCA AGAGCGCGAATAGAACTCCACGAAACAGACTTCAATGGGCAGAAGCTAAAGCTATATTTTGCACAGTCCTATCTCCTGCCGCCCCAGCCT GTCAAGCAGTTCCTCATCTCCCCTCCAGCCTCTCCCCCGGTGGGGTGGAAGCAGAGCGAAGATGCGATGCCTGTTATAAATTATGATTTA CTCTGTGCTGTTTCCAAATTGGGACCAGGAGAGAAATATGAACTTCACGCGGGAACAGAGTCGACACCCAGCGTGGTGGTTCATGTCTGT GAAAGTGAAACTGAAGAGGAAGAAGAGACAAAAAACCCCAAACAGAAAATTGCCCAGACGAGGCGCCCCGACCCTCCGACCGCAGCGTTG >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000374395_chr1_24857708_+_603nt ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGAAAGATTTGAAGCACTC TTCACCATCTATGATGACCAGGTTACTTTTCAGCTGTTTAAAAGCTTTAGAAGAGTCAGAATAAATTTCAGCAAACCTGAAGCGGCAGCA AGAGCGCGAATAGAACTCCACGAAACAGACTTCAATGGGCAGAAGCTAAAGCTATATTTTGCACAGGTGCAGATGTCCGGCGAAGTGCGG GACAAGTCCTATCTCCTGCCGCCCCAGCCTGTCAAGCAGTTCCTCATCTCCCCTCCAGCCTCTCCCCCGGTGGGGTGGAAGCAGAGCGAA GATGCGATGCCTGTTATAAATTATGATTTACTCTGTGCTGTTTCCAAATTGGGACCAGGAGAGAAATATGAACTTCACGCGGGAACAGAG TCGACACCCAGCGTGGTGGTTCATGTCTGTGAAAGTGAAACTGAAGAGGAAGAAGAGACAAAAAACCCCAAACAGAAAATTGCCCAGACG >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000412742_chr1_24857708_+_399nt ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGAAAGATTTGAAGCACTC TTCACCATCTATGATGACCAGGTTACTTTTCAGCTGTTTAAAAGCTTTAGAAGAGTCAGAATAAATTTCAGCAAACCTGAAGCGGCAGCA AGAGCGCGAATAGAACTCCACGAAACAGACTTCAATGGGCAGAAGCTAAAGCTATATTTTGCACAGGAGAGAAATATGAACTTCACGCGG GAACAGAGTCGACACCCAGCGTGGTGGTTCATGTCTGTGAAAGTGAAACTGAAGAGGAAGAAGAGACAAAAAACCCCAAACAGAAAATTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000436717_chr1_24857708_+_2507nt AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG AAAGATTTGAAGCACTCTTCACCATCTATGATGACCAGGTTACTTTTCAGCTGTTTAAAAGCTTTAGAAGAGTCAGAATAAATTTCAGCA AACCTGAAGCGGCAGCAAGAGCGCGAATAGAACTCCACGAAACAGACTTCAATGGGCAGAAGCTAAAGCTATATTTTGCACAGTCCTATC TCCTGCCGCCCCAGCCTGTCAAGCAGTTCCTCATCTCCCCTCCAGCCTCTCCCCCGGTGGGGTGGAAGCAGAGCGAAGATGCGATGCCTG TTATAAATTATGATTTACTCTGTGCTGTTTCCAAATTGGGACCAGGAGAGAAATATGAACTTCACGCGGGAACAGAGTCGACACCCAGCG TGGTGGTTCATGTCTGTGAAAGTGAAACTGAAGAGGAAGAAGAGACAAAAAACCCCAAACAGAAAATTGCCCAGACGAGGCGCCCCGACC CTCCGACCGCAGCGTTGAATGAGCCCCAGACCTTTGATTGCGCGCTGTGAGGCCCTTGGTTGTGGTGCGAGGCGGCTGCCCTGGTGGGCT CTGGCCATGGCGCTCTGTGCCTGCGGCCGATGCGTTGCTGCGAACAGCATAGGTGAGACTCTGCCGAGTGAGGTATAGGTCTTCTCACCA CGCCTGTACTGCAGACACGGTCGTGTAGAGTAGCAGCTGATTTGACCTGTCCCAGATTTTAAGTGATATTCCAAAAGGGACTTTACATTA AAGGAGAAGCCCCCAAGATGTGGCCACCCTTAACCATTTTTAAATAGTAACAAATTAGGAAAACAGCTCCCCTCCCCTCCAGCCATGTAA GTCCTCCTGATTCTGTATCACATGAGACACCAAAAACTGGAAATGTAGTCACACCCAGTACAGTACCATTTTTATGAATTTAAAAATAGT CTTATAATTTTAATTGTTTGTGGGTATTTTTCTACTGGTATAAATAGCTTCTAATTAATAAATCGATCAAAGGTTGTTACTCAGTATACA TGAAATTTTTTGCAGGAAAAGAAACCAGAAATACAGAATAATTCATAGAAATCATGGTTCTCAAGTATTTGTTCAATTAGCTTTGGGGAA GAAATGCCAAATCCACTTTGAGGATGAGTCTTACGACACAGATCCACCCACATGTTGCTCTTATCTGGAATTTGGGACAAAGCAATGCAC AGGCCCTCATTCCTGATGTGGCGCCCTCCAGACATGGCTGCCCAGGAAGGACGGCCACTTTAGAAGTGGGACGTATCACCAGTAAGCTTG AATGATTAGGATCGCAGGTGGCTACTGCATTCTGCCGTTCGTGACCGTGTTCTAGCCTGTAGACCACCCAGCTACCTTCATTCACCAGTT TTTATCCTTCACCTTTTCCAGTATCTTGTTAACCACTAGTTCTTGAGTTTTTTGGCTATGATGTGTACGTTTATGTATGTCATTCATGGA CTTTCAACTAGAAAAGGTAATGATAAGGTTTTCTGAAGACCATTTGTAAATTGTCCATTTAACCATTTTTCAGCTTGCTTTGAAACAAAA GTCACACCTACTATTTTTCTATGAATTAGGGAATGAGGGGGAGATCATTCAGTTTTACTTTTCTTTTTGTTGAAATTTTGTACCCGGATT GCAGTTGGCACTTTTCCTAAAACAGAATTGTTTCCCACTTAGGTGTCAGAATGTACCTTTGAACTTCCCTAAGAAGCAGCAGGATCTTTT TAACTCTCTCTGGTCTGTTTAGACTTTGAAGTCCCTTCTGTAGAAAAGTCTCATAACTGAGAAGGCTCTGTTTTGGGCCGGGTGGGTCTG CTGGCCTCCACTCACTGTGCTGTTTCCTTTGAGTGGCACACTTGGGAAGCTCCGGGGCATGTGAAGGAGCTGCAAACATGAGAACTAATG AACCAAGGCGGCTGCCACCAGGAAGGAACAGAACGCAGGCATTCAACCATGACGTCTGCACAGTGTTAGTAACATGTCATTGTGGTTTCG TTCTCACTGTGGTAAAATTTATTTCTGAGCACTTAAACTGTGTTGCATACCCCTAATTTTTTTTTTTTCTGTATCTTCCTTGCCCTCAAA TACCCTGAGGTGATAAACTGTTCCAGTTGTAGCCAACTACCACTGCTAGGCCTCAATGTAAATTCAGTTGAAATTTGCAATTCTATCAGC >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000374395_chr1_24857708_+_6563nt AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG AAAGATTTGAAGCACTCTTCACCATCTATGATGACCAGGTTACTTTTCAGCTGTTTAAAAGCTTTAGAAGAGTCAGAATAAATTTCAGCA AACCTGAAGCGGCAGCAAGAGCGCGAATAGAACTCCACGAAACAGACTTCAATGGGCAGAAGCTAAAGCTATATTTTGCACAGGTGCAGA TGTCCGGCGAAGTGCGGGACAAGTCCTATCTCCTGCCGCCCCAGCCTGTCAAGCAGTTCCTCATCTCCCCTCCAGCCTCTCCCCCGGTGG GGTGGAAGCAGAGCGAAGATGCGATGCCTGTTATAAATTATGATTTACTCTGTGCTGTTTCCAAATTGGGACCAGGAGAGAAATATGAAC TTCACGCGGGAACAGAGTCGACACCCAGCGTGGTGGTTCATGTCTGTGAAAGTGAAACTGAAGAGGAAGAAGAGACAAAAAACCCCAAAC AGAAAATTGCCCAGACGAGGCGCCCCGACCCTCCGACCGCAGCGTTGAATGAGCCCCAGACCTTTGATTGCGCGCTGTGAGGCCCTTGGT TGTGGTGCGAGGCGGCTGCCCTGGTGGGCTCTGGCCATGGCGCTCTGTGCCTGCGGCCGATGCGTTGCTGCGAACAGCATAGGTGAGACT CTGCCGAGTGAGGTATAGGTCTTCTCACCACGCCTGTACTGCAGACACGGTCGTGTAGAGTAGCAGCTGATTTGACCTGTCCCAGATTTT AAGTGATATTCCAAAAGGGACTTTACATTAAAGGAGAAGCCCCCAAGATGTGGCCACCCTTAACCATTTTTAAATAGTAACAAATTAGGA AAACAGCTCCCCTCCCCTCCAGCCATGTAAGTCCTCCTGATTCTGTATCACATGAGACACCAAAAACTGGAAATGTAGTCACACCCAGTA CAGTACCATTTTTATGAATTTAAAAATAGTCTTATAATTTTAATTGTTTGTGGGTATTTTTCTACTGGTATAAATAGCTTCTAATTAATA AATCGATCAAAGGTTGTTACTCAGTATACATGAAATTTTTTGCAGGAAAAGAAACCAGAAATACAGAATAATTCATAGAAATCATGGTTC TCAAGTATTTGTTCAATTAGCTTTGGGGAAGAAATGCCAAATCCACTTTGAGGATGAGTCTTACGACACAGATCCACCCACATGTTGCTC TTATCTGGAATTTGGGACAAAGCAATGCACAGGCCCTCATTCCTGATGTGGCGCCCTCCAGACATGGCTGCCCAGGAAGGACGGCCACTT TAGAAGTGGGACGTATCACCAGTAAGCTTGAATGATTAGGATCGCAGGTGGCTACTGCATTCTGCCGTTCGTGACCGTGTTCTAGCCTGT AGACCACCCAGCTACCTTCATTCACCAGTTTTTATCCTTCACCTTTTCCAGTATCTTGTTAACCACTAGTTCTTGAGTTTTTTGGCTATG ATGTGTACGTTTATGTATGTCATTCATGGACTTTCAACTAGAAAAGGTAATGATAAGGTTTTCTGAAGACCATTTGTAAATTGTCCATTT AACCATTTTTCAGCTTGCTTTGAAACAAAAGTCACACCTACTATTTTTCTATGAATTAGGGAATGAGGGGGAGATCATTCAGTTTTACTT TTCTTTTTGTTGAAATTTTGTACCCGGATTGCAGTTGGCACTTTTCCTAAAACAGAATTGTTTCCCACTTAGGTGTCAGAATGTACCTTT GAACTTCCCTAAGAAGCAGCAGGATCTTTTTAACTCTCTCTGGTCTGTTTAGACTTTGAAGTCCCTTCTGTAGAAAAGTCTCATAACTGA GAAGGCTCTGTTTTGGGCCGGGTGGGTCTGCTGGCCTCCACTCACTGTGCTGTTTCCTTTGAGTGGCACACTTGGGAAGCTCCGGGGCAT GTGAAGGAGCTGCAAACATGAGAACTAATGAACCAAGGCGGCTGCCACCAGGAAGGAACAGAACGCAGGCATTCAACCATGACGTCTGCA CAGTGTTAGTAACATGTCATTGTGGTTTCGTTCTCACTGTGGTAAAATTTATTTCTGAGCACTTAAACTGTGTTGCATACCCCTAATTTT TTTTTTTTCTGTATCTTCCTTGCCCTCAAATACCCTGAGGTGATAAACTGTTCCAGTTGTAGCCAACTACCACTGCTAGGCCTCAATGTA AATTCAGTTGAAATTTGCAATTCTATCAGCAATTTAATGTATTGAATTCAGATCATCATTTGTCATTTTAACCGACAACCACCCAATAAA TTTACTCTGCAGTTCTGAACTCAGCATTGTGCCCATTTTTTACTGCAAGATGGACCCTGTATGCCAGGAGACATGTATTATCAACAATTG GGAATTTTTTGAATTTCCTTTTAGGTAATATTGATTCACTGTAATTTTCTAAGTGATCAAAACCCATGAGATTTTGTTATTTGGCTTGGC TTTCATTCTCTGCCTGCCCATTAAAGAATATTCTATTCCTAACACATAAAACATTTTACAGTCAAGCAGTGCAAATTACAGTGCTTTTCT ATTTTTTTTTTGAGAGCCTTGAATAAATTGAAGAAAACTTTAAACCAAAATTAGAGACGAGTCATTTAAGCTTTTCTGAATGGAAAGTAT TAATATTTTCATTTTTCTAGTATAATATAATAAAATGAATTTTTTTAAAAAAGCTACTAAGTACCCATCAACTTTTTCATATTGTGAAAT GAACCAGGATCTTAACAGATACTATCATCGCTGTCCTTTTTTGGCTGTTTAATATCTAGTTCATGTAACAAATTTACAAGAGATAAGTCT CATGGTTTTTTTTTTCTTTTAATAGGCTTTTCTGCAATTTTTTTGAAATTGAGTTATTACTTGGATTTAACCCTGATAGGACCAGGTGTG GTGGCTCACACCATAATCCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCCACCTGAGGTCAGGAGTTCAAGACCAGCCTGACCAACATG GTGAAATCCTGTCTCTACTTAAAAAATACAAAATTAGCCTGGCATGGTGGCACATGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAG GAGAATTTCCTGAACCGGGAGACGGAGGTTGCGGTGAGCCGAGATCACGCCATCGCACTCCAGCCTCGGCAACAAGAGCGAAACTCCGTC TCAAAAAAAAAAGATTTAACCCTGATTGATAGTATAGTAGCCATGTTTTCTTTAGAAATCATAACCTCTTCATGGGAATCAAACTATGTT GAAAATTGTGAGGAAAGATAATGGTGCTTTGTGTTGGGAAAAAAACATTTGTGAAGGATTAGAAAACCGTAACACTTAACAAGGATAGTC ACAGAACCGACGCTGCATTGGCTCTTAGGTTCTAGATTTTTGTAGCACACTCACCTGATGAAACCAAAGACAAATCCATGTAAAAAGTGT TCCAGTGAGCATCTCTGAGGTTTAAGGTACTAAGAGGCAGAAGTGGATAGCAACAGTTCCATTGCCTTCGAGAACTAAAACTCAGCTGGA AAGCAAATTAGTCTTTTCACATTCTGCTTCTTCAAAATGTTGTACTCAAAAACATACCAGTAATTAAGAGCCAAAGCAAAGCTTCAAGGA ACTTTTAAGTTCAACATAAAGGTTTAAATAAAATATTTTTTATTTTTTATTTTTATTTATTTATTTATTTATTTTGAGACAGAGTCTCAC TCTGTCGCCCAGGCTGGAGCGCAGCCGCGTGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTC CCAAGTAGCTGGGACTACAGGCGCCCGCTCCCACGCCCGGCTAATTTTTTTTTTTTTTTTTTTTATAAGTAGAGACGGGGTTTCACCACG TTAGCCAGGATGGTCTCGATCTCCTGACCTAGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTAACCAGGCGTGAGCCACTGCG CCCGGCCTTAAATAAAATATTGTAGTCATTAATGGTGTGTTTGAATTGAAGAGATACCAGGAGATAGAGGTGAAGTGCAGTACTTTTATT CTTTAAGAATATAGTCTTTAGCCAGGTGCAGTGGTGTGTGCCTGTAGTCTCAGCTATTTGAGAGGCTGAGGTGAGAGGATCACTTGAGTT CAGGAGTTCAAGACCAGCCTGGGCAACATAGCAAGTCCCTGGCTCAAAAAAAAAAAAGTTTCCCATTCATATTAACTCCATCTTTTAAAA ATGTCATGATTACAAAGTGAAAAGATTTGGCTTTCTTAGAGGCTCAATCACAGAGGTGAAAGTGACCTTGGAAATCATATACTCTATCCC CATGTTACACAGATTAGAAAAACTGAGGTTATGGCACTGACTTAGGCACCCCCAGCAAGGCAACCCAGGGACTACAACTGGCAATCCCAA CTCCTGGGCTAGGGCTTTTTCTACCTTTTTTTGCATTGGCCTCTTAAAGAGGCAATGAATACTAATTCCTGGCATCAGAAAAAAAAAAAG GCATGAGGTGGGAGGATTCTTTTTTCCCTGATGGGAAACAGTGAATAAGAAAAATCTCATCATTCGATGGAAGAGGTGACTTAATAATTT TATTAATGAATTTGATGTCCCATGTTTTGTAGTTTTGTTATCATTGAACCATTGGGGCTGGAATCTGCCTAAATAATTTTATCTTGGTAG CCAGCAATTATGTTGGTATTTTATGTGGGCCTTCCCAGATTTTCATATTAATGAAATGACTAATAGTCGTACTTAAGAGGTAACTCTACT AAAGCAGAATGAGATCTAATATGTTGTGGAAATAAAAGAGTTTGCAGTGGAATGATACTCTCACTCCGTGCTTGTAAAATTGAGTTCTAT TCAAGACGGAACTGCTATGACTGGCCTATTCAAGGCTTCATATTTTTATACAGACTATTTCACAGACCATAGATTTATTTTAAAAGGGAA AATCTCACACATAATTAAGCAGTGGAAAATGTGCTCAATGCTATGGTGCGTCAGGCCCTCTGTCTACCAGGTTTCTCCCCTTTCTGCAGA GCTGTGGACCCTGTACGTACCAAACAGGTGAACTTGGTCCATCTTTCCTTCTTCCTTTTTTTGCACATTTGCATTTATATCTTCCTGTAC TAAAAGAAACAAATTATTTATAATTGGGGTGACAATATAAAGGAACAAAAGATGGGGCAATAGTTGCTTCCTAGCTGGAGCTGTAAGTCC ATGTTACAGAAACTCACTATTTAAAAAGTTTTAAAAGATTTATGAACCTTGTCCTACAATTCGCTGAATACTTATTTGTCTTTTAAACTC CCCTCGGTGTATGGATCATCTTCGTCAGAATGCCGTTGTTTCATTGTGAATCAGGGGAAAATGTTAATCATTTGGAGACTGTTTTCTTAT TACCAAATGTACAATCCATAAGACAACTGAAAGCAACAACTGCTGGGTTCACTGACAAAGATTATAAAAATCATCACGTTCAAAGTAGAG TTTTTAGCCAAGGTCAAGAACTAACCTGGGGCTGAGTCAGCGTCTCTACCCACTTAAATAACAGCGTAAAGATCTTTCACTAAATTCGTT ATGTGGTCTGTCTGGATGTAAACCTATATATTTCCTTTTGAAACAGAATCATATCCTGCAGACTCTTGGCACTCCTGCATAGCTTTGACC GAATGTTCACTCTCATCGTAATGGAAGATTTCTATCTATGCAGATAATACATGTTTTTAAATACTGTTTTCTGTTTAGTCCTCAATCTTC CTAACTCAAATTGGGGACTGAGGAGAGAGAAAGGTGGTTACCCCTGTTACCGTGCCATATTCTTCTTGCTGCTTTTCAACCCCACGTGAT TGTTGATTGACGGTTCTGCTATAATGTGCGTGCCCTTCAAGTTTCAGAAAACTTTCCCAATCATTTCACTTCAATCTTAATTGAACCCAA GAGTCAAAGTTATTATTTTCTCCGAACGTGTTTGTGATCTTCTGTTATATTTTGGGGCATGTTACCTTTATGGTATATAAGCTGTAGTGC ATACTCTTTGTATTGCAAAAAACTGGTCAGTAATTTATGTACATGTATTCCACATTTTAGTGTGCTTGAAGTGACAATCCATAGTTTGTA GTAGTTTGTTATTTGTCAACTTTACCCTGTGTTTTAAGGACATCTAAACATTCCTTGTCCTATCAAGATGACAAAAGCAGAATGTAATTT >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_RCAN3_ENST00000412742_chr1_24857708_+_688nt AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG AAAGATTTGAAGCACTCTTCACCATCTATGATGACCAGGTTACTTTTCAGCTGTTTAAAAGCTTTAGAAGAGTCAGAATAAATTTCAGCA AACCTGAAGCGGCAGCAAGAGCGCGAATAGAACTCCACGAAACAGACTTCAATGGGCAGAAGCTAAAGCTATATTTTGCACAGGAGAGAA ATATGAACTTCACGCGGGAACAGAGTCGACACCCAGCGTGGTGGTTCATGTCTGTGAAAGTGAAACTGAAGAGGAAGAAGAGACAAAAAA CCCCAAACAGAAAATTGCCCAGACGAGGCGCCCCGACCCTCCGACCGCAGCGTTGAATGAGCCCCAGACCTTTGATTGCGCGCTGTGAGG |
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FusionGenePPI for CLIC4_RCAN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLIC4 | CDK2, SPRTN, HNRNPA1, HSP90AB1, REL, CLIC2, CLIC6, CLIC5, TPRN, ACADS, CDA, CSK, EZR, FDPS, HADH, HIBCH, PSMA1, PSMA2, PSMA5, PSMB1, PSMB7, SHC1, SUGT1, TAGLN2, TAGLN3, TPD52, COASY, CRKL, DAG1, DDB1, DNAJC9, HNRNPH2, LSM3, NDRG1, P4HB, PDCD6, PSMA3, PSMB4, RABIF, SEPHS1, ST13, UBA2, NTRK1, ICAM1, TRIM25, G3BP1 | RCAN3 | TNNI3, ZDHHC17, PPP3CB, PPP3CC, PPP3CA, C6orf211, CDK4, OBSL1, PPP3R1, SMYD3, GRB10, EPS8, PLS1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLIC4_RCAN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLIC4_RCAN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CLIC4 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | CLIC4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | CLIC4 | C0043094 | Weight Gain | 1 | CTD_human |
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