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Fusion gene ID: 7384 |
FusionGeneSummary for CLIC4_ARFGAP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLIC4_ARFGAP3 | Fusion gene ID: 7384 | Hgene | Tgene | Gene symbol | CLIC4 | ARFGAP3 | Gene ID | 25932 | 26286 |
| Gene name | chloride intracellular channel 4 | ADP ribosylation factor GTPase activating protein 3 | |
| Synonyms | CLIC4L|H1|MTCLIC|huH1|p64H1 | ARFGAP1 | |
| Cytomap | 1p36.11 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chloride intracellular channel protein 4chloride intracellular channel 4 likeintracellular chloride ion channel protein p64H1 | ADP-ribosylation factor GTPase-activating protein 3ADP-ribosylation factor GTPase activating protein 1ARF GAP 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y696 | Q9NP61 | |
| Ensembl transtripts involved in fusion gene | ENST00000374379, ENST00000497755, | ENST00000263245, ENST00000429508, ENST00000437119, | |
| Fusion gene scores | * DoF score | 9 X 3 X 7=189 | 5 X 5 X 4=100 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/189*10)=-1.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CLIC4 [Title/Abstract] AND ARFGAP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLIC4 | GO:0030336 | negative regulation of cell migration | 12163372 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-PD-A5DF-01A | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374379 | ENST00000263245 | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
| In-frame | ENST00000374379 | ENST00000429508 | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
| In-frame | ENST00000374379 | ENST00000437119 | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
| 3UTR-3CDS | ENST00000497755 | ENST00000263245 | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
| 3UTR-3CDS | ENST00000497755 | ENST00000429508 | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
| 3UTR-3CDS | ENST00000497755 | ENST00000437119 | CLIC4 | chr1 | 25072116 | + | ARFGAP3 | chr22 | 43243638 | - |
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FusionProtFeatures for CLIC4_ARFGAP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLIC4 | ARFGAP3 |
| Can insert into membranes and form poorly selective ionchannels that may also transport chloride ions. Channel activitydepends on the pH. Membrane insertion seems to be redox-regulatedand may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions likea potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.Could also promote endothelial cell proliferation and regulateendothelial morphogenesis (tubulogenesis).{ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596,ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224,ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}. | GTPase-activating protein (GAP) for ADP ribosylationfactor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead todissociation of coatomer from Golgi-derived membranes to allowfusion with target membranes. {ECO:0000269|PubMed:11172815}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000263245 | - | 0 | 16 | 243_263 | 23 | 517 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000437119 | - | 0 | 15 | 243_263 | 23 | 473 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000263245 | - | 0 | 16 | 348_377 | 23 | 517 | Compositional bias | Note=Ser-rich |
| Tgene | >ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000437119 | - | 0 | 15 | 348_377 | 23 | 473 | Compositional bias | Note=Ser-rich |
| Tgene | >ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000263245 | - | 0 | 16 | 25_48 | 23 | 517 | Zinc finger | C4-type |
| Tgene | >ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000437119 | - | 0 | 15 | 25_48 | 23 | 473 | Zinc finger | C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CLIC4 | chr1:25072116 | chr22:43243638 | ENST00000374379 | + | 1 | 6 | 104_244 | 24 | 254 | Domain | Note=GST C-terminal |
| Hgene | >CLIC4 | chr1:25072116 | chr22:43243638 | ENST00000374379 | + | 1 | 6 | 2_101 | 24 | 254 | Region | Required for insertion into the membrane |
| Hgene | >CLIC4 | chr1:25072116 | chr22:43243638 | ENST00000374379 | + | 1 | 6 | 37_57 | 24 | 254 | Transmembrane | Helical%3B Note%3DAfter insertion into the membrane |
| Tgene | ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000263245 | - | 0 | 16 | 10_126 | 23 | 517 | Domain | Arf-GAP |
| Tgene | ARFGAP3 | chr1:25072116 | chr22:43243638 | ENST00000437119 | - | 0 | 15 | 10_126 | 23 | 473 | Domain | Arf-GAP |
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FusionGeneSequence for CLIC4_ARFGAP3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000263245_chr22_43243638_-_518aa MALSMPLNGLKEEDKEPLIELFVKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASASS FFHQHGCSTNDTNAKYNSRAAQLYREKIKSLASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRP VETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEE SIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDE PVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLER >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000429508_chr22_43243638_-_446aa MALSMPLNGLKEEDKEPLIELFVKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASAVS DTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQA ADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKY NDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDM >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000437119_chr22_43243638_-_474aa MALSMPLNGLKEEDKEPLIELFVKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASALW LDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKK GLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCR SVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTAR RKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLPNAPDMAQFKQGVR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000263245_chr22_43243638_-_1554nt ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGTGTGTTTTGATTGTGGT GCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGTCACTTGGTGTTCACTTG AGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAAACGCTAGTGCATCTTCC TTTTTTCATCAACATGGGTGTTCCACCAATGACACCAATGCCAAGTACAACAGTCGTGCTGCTCAGCTCTATAGGGAGAAAATCAAATCG CTCGCCTCTCAAGCAACACGGAAGCATGGCACTGATCTGTGGCTTGATAGTTGTGTGGTTCCACCTTTGTCCCCTCCACCAAAGGAGGAA GATTTTTTTGCCTCTCACGTTTCTCCTGAGGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCT GTGGAAACCACTTTGGAAAATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAG GTATCCTCTATCATAAAAAAGAAACCAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAAC ACATGCTTTAATGAAATTGAAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAA TCAATTGTTTCATCATTACGATTAGCCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAAT GTTGACTCAGACAGACTCGGCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAG GAATCACCCATTATGGCAAAACCAAGAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAG CCAGTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACA GTTCTGAAAACCACAGGCTATTCAGACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAG AAGTTTGGCAATGTCAAGGCCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGG CTGTCGGCAAGTTCCTCCATAAGCTCGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTG CCCAACGCCCCCGACATGGCGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTAATGGAGTCGTGACTTCA >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000429508_chr22_43243638_-_1338nt ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGTGTGTTTTGATTGTGGT GCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGTCACTTGGTGTTCACTTG AGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAAACGCTAGTGCAGTGAGT GACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAAATAATGAAGGTGGACAA GAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAACCAAATCAAGCT AAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACATGCTTTAATGAAATTGAAAAACAAGCTCAAGCT GCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAGCCTATAAGGAT CTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCGGCATGGGATTTGGAAAT TGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAAGAAAAAAGTAT AATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGG GATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAGACAGACCTACT GCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGGCCATTTCATCAGATATG TATTTTGGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCTCGGCTGATCTG TTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGGCGCAGTTCAAGCAGGGA >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000437119_chr22_43243638_-_1422nt ATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGGTGTGTTTTGATTGTGGT GCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGTCACTTGGTGTTCACTTG AGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAAACGCTAGTGCACTGTGG CTTGATAGTTGTGTGGTTCCACCTTTGTCCCCTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTCCTGAGGTGAGTGACACA GCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAAATAATGAAGGTGGACAAGAGCAA GGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAACCAAATCAAGCTAAAAAA GGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACATGCTTTAATGAAATTGAAAAACAAGCTCAAGCTGCGGAT AAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAGCCTATAAGGATCTTGAA ATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCGGCATGGGATTTGGAAATTGCAGA AGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAAGAAAAAAGTATAATGAT GACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGGGATGAC AGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAGACAGACCTACTGCTCGC CGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGGCCATTTCATCAGATATGTATTTT GGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCTCGGCTGATCTGTTCGAG GAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGGCGCAGTTCAAGCAGGGAGTGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000263245_chr22_43243638_-_2837nt AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG TGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGT CACTTGGTGTTCACTTGAGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAA ACGCTAGTGCATCTTCCTTTTTTCATCAACATGGGTGTTCCACCAATGACACCAATGCCAAGTACAACAGTCGTGCTGCTCAGCTCTATA GGGAGAAAATCAAATCGCTCGCCTCTCAAGCAACACGGAAGCATGGCACTGATCTGTGGCTTGATAGTTGTGTGGTTCCACCTTTGTCCC CTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTCCTGAGGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTT CTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAAATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAA CAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAACCAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAG CTCAGAAACTGGCAAACACATGCTTTAATGAAATTGAAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGG TGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAGCCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACA TTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCGGCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATA TGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAAGAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCT CAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCAGTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCA GCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAGACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATA CAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGGCCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCA GGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCTCGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACA GCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGGCGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTA ATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTTCTTAATACTGAAGTCATGATGTGTATTTCCTGGAGAAATTCCTCTTTAAATGAA CAAGTAACCACATCTCAGGCGGCAGTGAAGTCCAGATAGTTTTGCAGATTGTTTTGCTACTTTTTCATATGGTATATGTTTCTGATTTTT AATATTTCTTTTGAGAAATTCTGAGTTCTGATGTAGGAGCTTTCCTGTGATTTCTGTTTCACGTTCCTTCCTGTCACACCCTCCTTTGGC GTCTCTGTGTATATCCTTGCTTTATTTTCTTGGAACCTTTGATTTCAACACTGAGGGCCTGGAGACCTCGGCTCCTCCTGCTCCTGAACC AGGAGGCTTCATGTGGGGGAGGAGGAGAGGTCTCCATGTGACACATGGGCTCAGGGCTGCCAGAATCAGCGGATGCTGGATGGGCCTGCA GAAACAACACTCACCACACACACTTCCTTCAAAAGACCAAAAGTGACTGGTGTCTCGTGTGACAGATTGCTTCATTTATGTTTCTACATA GTAAGGTGACTGCCAAATAATATTTGAAGTCATCTGTCTCTTTGTAAATTATTTTATATGACCTATAAATTTAAAAATGTTTTTCAGTGA GTGCTTTTAACAAACTTAAGCTTCTGCCCTGCCAAGGGAATTAATGTTATCTTGTGAAAGGTGTTGCTGTTTGAATTGATGAGAAATGGA AGATGAGAACTCCCTAAGAGTTCTCATAATAAATCATCTCATCACAAATCAATACGGTATACAGAGTTAAAGTGGAATGAGGTAAGAAGA TACAGCTACAGAAAATAGTTGCGTGTATGGGAGAACAGTCATTGTAATTGGGTAGTTTTGTTAATAAATATTTTTAAATCTTGCTTTTCA GAAATTACCGAATGTGTATAAACAAATAAAGAAAAATAATTTAGCTGTGTTTTAGACAGCATTAGAATATATTGTTCAGCACAGTAAAAT ATATTTGAAATTTGATAAGCCAAAAATGTGGTTTTGAATGAATATTTTGTGAATCTTTCTTAAAAGCTCAAATTTGTAGACTTCTAAATA >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000429508_chr22_43243638_-_1754nt AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG TGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGT CACTTGGTGTTCACTTGAGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAA ACGCTAGTGCAGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAA ATAATGAAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAA AGAAACCAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACATGCTTTAATGAAATTG AAAAACAAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTAC GATTAGCCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCG GCATGGGATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAA AACCAAGAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCA GTTCTTTCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCT ATTCAGACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGG CCATTTCATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCA TAAGCTCGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGG CGCAGTTCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTAATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTT CTTAATACTGAAGTCATGATGTGTATTTCCTGGAGAAATTCCTCTTTAAATGAACAAGTAACCACATCTCAGGCGGCAGTGAAGTCCAGA TAGTTTTGCAGATTGTTTTGCTACTTTTTCATATGGTATATGTTTCTGATTTTTAATATTTCTTTTGAGAAATTCTGAGTTCTGATGTAG >In-frame_CLIC4_ENST00000374379_chr1_25072116_+_ARFGAP3_ENST00000437119_chr22_43243638_-_1793nt AAGCGGCTCGGGCTGCGGCTGGCTCAGAGTGGCGCGGGGGGCGTGGGGCGGTGCTGAGGAGCTGAAGCCGTGGCCAGCTCGACGCCGGAC AGTCCAGCGAGCAGCACGGCGGGAACCGGCAGCCGGAGCAGTCCCGGAGCAGAAGCAGCAGCAGCAGCAGCAGCCCTCGCCGTTCGCGGA GCGCAGCCGAGCCGGCCATGGCGTTGTCGATGCCGCTGAATGGGCTGAAGGAGGAGGACAAAGAGCCCCTCATCGAGCTCTTCGTCAAGG TGTGTTTTGATTGTGGTGCCAAAAATCCCAGCTGGGCAAGCATAACCTATGGAGTGTTCCTTTGCATTGATTGCTCAGGGTCCCACCGGT CACTTGGTGTTCACTTGAGTTTTATTCGATCTACAGAGTTGGATTCCAACTGGTCATGGTTTCAGTTGCGATGCATGCAAGTCGGAGGAA ACGCTAGTGCACTGTGGCTTGATAGTTGTGTGGTTCCACCTTTGTCCCCTCCACCAAAGGAGGAAGATTTTTTTGCCTCTCACGTTTCTC CTGAGGTGAGTGACACAGCGTGGGCATCAGCAATAGCAGAACCATCTTCTTTAACATCAAGGCCTGTGGAAACCACTTTGGAAAATAATG AAGGTGGACAAGAGCAAGGACCAAGTGTGGAAGGTCTTAATGTACCAACAAAGGCTACTTTAGAGGTATCCTCTATCATAAAAAAGAAAC CAAATCAAGCTAAAAAAGGCCTTGGGGCCAAAAAAGGAAGTTTGGGAGCTCAGAAACTGGCAAACACATGCTTTAATGAAATTGAAAAAC AAGCTCAAGCTGCGGATAAAATGAAGGAGCAGGAAGACCTGGCCAAGGTGGTATCTAAAGAAGAATCAATTGTTTCATCATTACGATTAG CCTATAAGGATCTTGAAATTCAAATGAAGAAAGACGAAAAGATGAACATTAGTGGCAAAAAAAATGTTGACTCAGACAGACTCGGCATGG GATTTGGAAATTGCAGAAGTGTTATTTCACATTCAGTGACTTCAGATATGCAGACCATAGAGCAGGAATCACCCATTATGGCAAAACCAA GAAAAAAGTATAATGATGACAGTGACGATTCATATTTTACTTCCAGCTCAAGTTACTTTGACGAGCCAGTGGAGTTAAGGAGCAGTTCTT TCTCTAGCTGGGATGACAGTTCAGATTCCTATTGGAAAAAAGAGACCAGCAAAGATACTGAAACAGTTCTGAAAACCACAGGCTATTCAG ACAGACCTACTGCTCGCCGCAAGCCAGATTATGAGCCAGTTGAAAATACAGATGAGGCCCAGAAGAAGTTTGGCAATGTCAAGGCCATTT CATCAGATATGTATTTTGGAAGACAATCCCAGGCTGATTATGAGACCAGGGCCCGCCTAGAGAGGCTGTCGGCAAGTTCCTCCATAAGCT CGGCTGATCTGTTCGAGGAGCCGAGGAAGCAGCCAGCAGGGAACTACAGCCTGTCCAGTGTGCTGCCCAACGCCCCCGACATGGCGCAGT TCAAGCAGGGAGTGAGATCGGTTGCTGGAAAACTCTCCGTCTTTGCTAATGGAGTCGTGACTTCAATTCAGGATCGCTACGGTTCTTAAT ACTGAAGTCATGATGTGTATTTCCTGGAGAAATTCCTCTTTAAATGAACAAGTAACCACATCTCAGGCGGCAGTGAAGTCCAGATAGTTT |
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FusionGenePPI for CLIC4_ARFGAP3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLIC4 | CDK2, SPRTN, HNRNPA1, HSP90AB1, REL, CLIC2, CLIC6, CLIC5, TPRN, ACADS, CDA, CSK, EZR, FDPS, HADH, HIBCH, PSMA1, PSMA2, PSMA5, PSMB1, PSMB7, SHC1, SUGT1, TAGLN2, TAGLN3, TPD52, COASY, CRKL, DAG1, DDB1, DNAJC9, HNRNPH2, LSM3, NDRG1, P4HB, PDCD6, PSMA3, PSMB4, RABIF, SEPHS1, ST13, UBA2, NTRK1, ICAM1, TRIM25, G3BP1 | ARFGAP3 | APP, CD14, CXCL8, ZDHHC17, SHPK, ADI1, ARFGAP1, ARF1, HSD17B10, TPPP3, MKS1, CEP128, DYNLT1, TMEM17, TMEM216, XPO1, TRIM26, WDYHV1, CCDC102B, PLEC, PPIP5K2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLIC4_ARFGAP3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CLIC4_ARFGAP3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CLIC4 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | CLIC4 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Hgene | CLIC4 | C0043094 | Weight Gain | 1 | CTD_human |
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