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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 7381

FusionGeneSummary for CLIC1_NUDT3

check button Fusion gene summary
Fusion gene informationFusion gene name: CLIC1_NUDT3
Fusion gene ID: 7381
HgeneTgene
Gene symbol

CLIC1

NUDT3

Gene ID

1192

11165

Gene namechloride intracellular channel 1nudix hydrolase 3
SynonymsCL1C1|G6|NCC27DIPP|DIPP-1|DIPP1
Cytomap

6p21.33

6p21.31

Type of geneprotein-codingprotein-coding
Descriptionchloride intracellular channel protein 1RNCC proteinchloride channel ABPhRNCCnuclear chloride ion channel 27nuclear chloride ion channel proteinp64CLCPregulatory nuclear chloride ion channel proteindiphosphoinositol polyphosphate phosphohydrolase 1diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1nucleoside diphosphate-linked moiety X motif 3nudix (nucleoside diphosphate linked moiety X)-type motif 3nudix motif 3
Modification date2018052320180523
UniProtAcc

O00299

O95989

Ensembl transtripts involved in fusion geneENST00000375784, ENST00000375779, 
ENST00000375780, ENST00000395892, 
ENST00000457485, ENST00000423804, 
ENST00000447369, ENST00000447338, 
ENST00000422167, ENST00000438708, 
ENST00000431921, ENST00000415179, 
ENST00000418285, ENST00000423055, 
ENST00000442045, ENST00000435242, 
ENST00000400052, ENST00000383404, 
ENST00000383405, ENST00000400058, 
ENST00000456863, ENST00000434202, 
ENST00000420458, ENST00000433916, 
ENST00000425464, ENST00000423143, 
ENST00000438750, ENST00000451546, 
ENST00000607016, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 3 X 5=75
# samples 37
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/75*10)=-0.0995356735509144
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLIC1 [Title/Abstract] AND NUDT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCLIC1

GO:0006821

chloride transport

9139710

TgeneNUDT3

GO:0071544

diphosphoinositol polyphosphate catabolic process

10585413


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-BF-AAP4-01ACLIC1chr6

31701343

-NUDT3chr6

34263462

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000375784ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
Frame-shitENST00000375779ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
In-frameENST00000375780ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
In-frameENST00000395892ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000457485ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000423804ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000447369ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000447338ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000422167ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000438708ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000431921ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000415179ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000418285ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000423055ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000442045ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000435242ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000400052ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000383404ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000383405ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000400058ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000456863ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000434202ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000420458ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000433916ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000425464ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000423143ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000438750ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-
intron-3CDSENST00000451546ENST00000607016CLIC1chr6

31701343

-NUDT3chr6

34263462

-

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FusionProtFeatures for CLIC1_NUDT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLIC1

O00299

NUDT3

O95989

Can insert into membranes and form chloride ionchannels. Channel activity depends on the pH. Membrane insertionseems to be redox-regulated and may occur only under oxydizingconditions. Involved in regulation of the cell cycle.{ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932,ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526,ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939,ECO:0000269|PubMed:9139710}. Cleaves a beta-phosphate from the diphosphate groups inPP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4(bisdiphosphoinositol tetrakisphosphate), suggesting that it mayplay a role in signal transduction. InsP6 (inositolhexakisphophate) is not a substrate. Acts as a negative regulatorof the ERK1/2 pathway. Also able to catalyze the hydrolysis ofdinucleoside oligophosphates, with Ap6A and Ap5A being thepreferred substrates. The major reaction products are ADP and p4afrom Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. {ECO:0000269|PubMed:9822604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLIC1_NUDT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CLIC1_ENST00000375780_chr6_31701343_-_NUDT3_ENST00000607016_chr6_34263462_-_230aa
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLTGTEVHTDTNKIEEFLEAVLCP
PRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDSWSKRDIGKISWNF_EPGEEAQDVCLCAHCH_SAGRLGRFS_HWKEEGMV_NR

>In-frame_CLIC1_ENST00000395892_chr6_31701343_-_NUDT3_ENST00000607016_chr6_34263462_-_103aa
AGVKGTLGRLVGIFENQERKHRTTVTVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQTHKPVQASTFETLRQGYSANNGTPVVATTY


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CLIC1_ENST00000375780_chr6_31701343_-_NUDT3_ENST00000607016_chr6_34263462_-_691nt
ATGGCTGAAGAACAACCGCAGGTCGAATTGTTCGTGAAGGCTGGCAGTGATGGGGCCAAGATTGGGAACTGCCCATTCTCCCAGAGACTG
TTCATGGTACTGTGGCTCAAGGGAGTCACCTTCAATGTTACCACCGTTGACACCAAAAGGCGGACCGAGACAGTGCAGAAGCTGTGCCCA
GGGGGGCAGCTCCCATTCCTGCTGTATGGCACTGAAGTGCACACAGACACCAACAAGATTGAGGAATTTCTGGAGGCAGTGCTGTGCCCT
CCCAGGTACCCCAAGCTGGCAGCTCTGAACCCTGAGTCCAACACAGCTGGGCTGGACATATTTGCCAAATTTTCTGCCTACATCAAGAAT
TCAAACCCAGCACTCAATGACAGCTGGAGTAAAAGGGACATTGGGAAGATTAGTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGAC
GTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGATTCAGTTAACATTGGAAGGAAGAGGGAATGGTTTAAAATAGA
AGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATATTTTGAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCAC

>In-frame_CLIC1_ENST00000395892_chr6_31701343_-_NUDT3_ENST00000607016_chr6_34263462_-_309nt
GCTGGAGTAAAAGGGACATTGGGAAGATTAGTTGGAATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTC
ACTGAAGTGCTGGAAGACTGGGAAGATTCAGTTAACATTGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAG
TATCACAAACCCGTGCAGGCATCATATTTTGAAACATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CLIC1_ENST00000375780_chr6_31701343_-_NUDT3_ENST00000607016_chr6_34263462_-_10338nt
CCAAGTAGCTGGGATTACAGGTGCCCACCACCCCGCCTGGCAAATTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGTC
TGGTCTTGACTCCCTGACCTCAGGTGATCCACCCCCCTTGGCCTCCTAAAGTGTTGGGATTACAGGCGTGAGCCACCTCACCCGGCCCCT
AACTCTATTTCCTATGCCCAATCCCAAGTGTAGGCCACAAGGACTGCAAGTCCTAGTGCTGAGCTGGGCCCGGAGACAGTAGACTGCGGG
GGGCACAGGACCTACTGAGACACCAGTCTGGGCAGCTCAGGGAGTGCTGGCGTCACCCCTTCCCTAATCCCAGGCTGCATGGCTAACGGT
TCCTATCTGCAGTCCCAGCCTTCCACTTCCGAGTTCTTCTCTCAGACCACAGTCCCAGCAACCCAGAATTTGGATTGGAGTCTGGAAGAA
ATGCAGAATGATTAAACGACCACCTTTCCATTTGAAGTCCCCATCCCTGAATCTTCACGGGTGTGCCCAAGCTCCCCTCCCAGTTCCCCC
AGGGACGGCCACTTCCTGGTCCCCGACGCAACCATGGCTGAAGAACAACCGCAGGTCGAATTGTTCGTGAAGGCTGGCAGTGATGGGGCC
AAGATTGGGAACTGCCCATTCTCCCAGAGACTGTTCATGGTACTGTGGCTCAAGGGAGTCACCTTCAATGTTACCACCGTTGACACCAAA
AGGCGGACCGAGACAGTGCAGAAGCTGTGCCCAGGGGGGCAGCTCCCATTCCTGCTGTATGGCACTGAAGTGCACACAGACACCAACAAG
ATTGAGGAATTTCTGGAGGCAGTGCTGTGCCCTCCCAGGTACCCCAAGCTGGCAGCTCTGAACCCTGAGTCCAACACAGCTGGGCTGGAC
ATATTTGCCAAATTTTCTGCCTACATCAAGAATTCAAACCCAGCACTCAATGACAGCTGGAGTAAAAGGGACATTGGGAAGATTAGTTGG
AATTTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGATTCAGTTAA
CATTGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATATTTTGAAAC
ATTGAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATACTCGGTTTCTGCTCAGAGCTCGATGTCAGGCATCAG
ATGACTGAAGACTTCCTGTAAGAGAAATGGAAATTGGAAACTAGACTGAAGTGCAAATCTTCCCTCTCACCCTGGCTCTTTCCACTTCTC
ACAGGCCTCCTCTTTCAAATAAGGCATGGTGGGCAGCAAAGAAAGGGTGTATTGATAATGTTGCTGTTTGGTGTTAAGTGATGGGGCTTT
TTCTTCTGTTTTTATTGAGGGTGGGGGTTGGGTGTGTAATTTGTAAGTACTTTTGTGCATGATCTGTCCCTCCCTCTTCCCACCCCTGCA
GTCCTCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTTGGATTCTGAAGTGTTCCTGTTTGTCTTATCCTGGCCCTGGCCAGACGTTTTCT
TTGATTTTTAATTTTTTTTTTTTATTAAAAGATACCAGTATGAGATGAAAACTTCCAATAATTTGTCCTATAATGTGCTGTACAGTTCAG
TAGAGTGGTCACTTTCACTGCAGTATACATTTATCTACACATTATATATCGGACATATAATATGTAAATAAATGACTTCTAGAAAGAGAA
ATTTGTTTAATTTTTCAAGGTTTTTTTCTCTTTTAATTTGGGCATTTCTAGAATTGAGAGCCTCACAATTAACATACCTTTTTGTTTTCG
ATGCTAGTGGCTGGGCAGGTTGCCCTGTCCTTTCTCTATTTCCCAGTCATTGACTGTAGATATGGGAAGAGTTTAGCTACCTTCATAGTG
CTCCCAGGACTCATGGCCTTTCCTTCTTTAAGCTGTATTTCCCTGCCCAGAAAGAAACAGGAAGAAACCTTTTTTTATTTTTTTATTTTT
TTTTAACCAAGCAAGGAGCAAATGGCCTCAGCCCAGATCTGTAAAAACAATGATAGAAATTGAATTCTGCCCCACATGTTGACAGTAGAG
TTGGAACTGGATTCTTGGGATTACTTATCTAAAAAACTGGAGCATCAGGTCCATTTCTGTTCTGCTGGTTTGGAATCTTTTCCGTAATGC
TATTTATTGCCAACAATGGCCTCTCTTTGTGTCCATATATGCCTTACACCGTGCTGACCTGGGTATCATCCATGTGCTCTGAAGCATCCA
ACTTTACTTTGCAGGTGCATCAATGTAGTCCTGTCCCTGAACTGAGTAACCGTGTTCCTGAAAAGTACACTAGGGAAATTCACCTGCTTG
CTTGTCTTTGTATTGGCATGGCACTTGTGATTGCACCATGGAGCATGCTCAGAGCTATTAAATTGGTCTCCCATCTCCCACCAGGATATG
AAAGGTCCATATGGGAGGCCACGTAATCACTTATTACAGTGGTTACATAATACACTGGCTCACTGCAGACTCTCTTGTTTTTTGATACAG
TTTCGTGCTGGCTTCATTTGCCAATTGTGTTGTTTAGTTCGGAAGTAAGAGGGTCTTGAGATTGAGGGGTAGGGAGGGCTACACTGACTG
ATCCGTGGCTTAAGACAGGAGATTATCTCTGTACTCCAGTGGCATCTCCTTAGCCAAGATGTGAAATTAAAATCATAGTTCGCCTCATTT
AAAAATTCTAATAAAGCACTCAAACTTTGAAAAGCTTTTACTTTTCCCTCCTACTAAAAGAAATGTATGTACCTCATAGCCCTGTGTCAT
TTAGTGTTCAGCACTTTTGGGAACATCAGTTGGTGAACTTTAAATTTTGCTGTCTACTCACTGGGCACGGTGGCTCACACCTGTAATCCC
AGCACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAA
AAATGCAGAAATTAGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGAGATAATCGCTTGAACCTGGGAGGCAGAGGTTGCA
GTGAGCCGAGATTGCACCACTGTCGTCCAGCCTGGGTGATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATTTTTTTTTTTTT
TTTTGCTATATACTCTTAGTTTACATCCTCTCCCCCAATCTTCACACACAGAGCCAAAGAGCAGTTATATTCTTGGGATACCATGATACC
TCTGGGAAAGGAATTATATTCCCAAGGAGAGGTCCCATTGGATAAGAACAATACCATGGGACTTGAGTCTGAATGCCAACTTACTATTCA
CACATCCTTCTTAAAAACGAACACACTGTTTCTTTTCCTGACCTAGAGCATTCTAAAGTTCTGTTCAAATAAATAAAGGGCAAAATAAAG
TAGATTTAACCAAGTGCCAGGTGGAATTCAAAAAACACATTCTTCCAGATAAATTCTACCTTTATGGTATGGATTTGAAAGTACTTTGCA
GGAAAACAGTCAGTACTCTTTAAAAAGGGACTGCAGGGCTGGGTGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCA
GGTGGGTCACTTGAGGCCAGGAGTTTGAGACCAGCCTGACCAACATGGCAAAACCCCATCTCTACTAAAATACAAAAATTAGCTGGGCAT
GATGGTGCACTCCTGTAATCCCAGCTACTTGGTAGGCTGAAGCATGAGAATTGCTTAAACCTGGGAGGCAGAGGTTGCAGTAAGCCAAGA
TCATGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTGTCTTAATAAATAAATAAGAAAATAAAACGGAACTGCAGTGCTAACAG
TAATTTATACATTTTTAAATGTTCTGAGTATGTTTTGACTGGGCTAGTGTAACAATATACTACCCTGAAAGTGCAGTTTTGATTGTTGTT
GGTGTCTTTGGGTCAGGAAAGTGAACTGTGCCAAGAAGTATTTTTCAGTGACATGAATGGATTCCTGTTAATGCAATTGACTGAGAGATT
GTGCTTACGCTTTCTTAACTGACAAAAAGAGGCTTTGTCCAACATCAGAATTGTTGAAACTGGTGCTGTTTTCTGTTGCACTGGGATTCT
GATGATCTGGGATTTTCCCTCCTTGGCACAGTAAACACCATGACTGTCTTTATTGAGAATGTCGTCACAGTCCTTTAGTGATAGATTAGT
TAGACCCATGGTTGCAATACCTTTATCTCCCCAAAGAAAATAATCAAAAGAAAGCACAAAAGCTACCCTGTTTGCAGAATATTTCACTGA
CATTGATTTGTCATTAATTCTACCAGAGCTGACCTCATTCAGGCTTGATAGAAACAGGTTCCTATGTTTAGGGCAGATCCCTAGCCTCTC
GCTCACAGTGAGTCTGCATGTCCTAGATTCTGGTTATTGCTGGAGCATCCATTAAAGTCTACCAAACTCAGGACAGAAGAAGATAGCAGT
GGATTTGTAAAAATTTTTAGTTTATAAATTACAGTCATTGGGGAAACACTAGTAAGGTCATGTGATCTTTTGGACCAGGATTTTCTCTCT
GTCTTCTCTCTGGGTGTGTGTGTGTGTATGTACAGAAGGGCTACCAGGAAGTGTCAACCATGTTAGATTTTCTGTAGTCTTCCAGAAACA
GTGCAGCCCATACAACAGGAATCTTAATTTTCCTCACAGCAAATATAACAGGATGGAACAGTTAGTGTTTTGTTTTCACAAGTGTCCACC
ACTCCATCTGCCCTGCATGGAGAGGGCTCTCTCACTGCTAGATCTAGGCTGAGCCATCTGGAAGGATCAAAGGGTGTGGGAGTATCACCC
CCTCTCAGGCTGCAGAAGGTCTCGAGGGTGGCGTCACAGCAGGATTTCCGCCTTCTGCATTGCACTGCACAGCCCCATGGAACATGAGGC
ACTTGAGGCCTTGCTTCTTGGAGCCTCTGGGGAGCAGAGTAGGTCACTGCCCTCTGGGAGTGTTTTGCAGTAGTTTTGTAAATGTGTTGC
TACATAGTCAAGTTCCTTTGTGGCAAAGAAATATTTTGTTTTGATATTAGGAGCCAGCCCATGTAATGCCTCTCAGGCTTGCTTGCTTAG
AAGAAAAAAGTCACCCTTTGTGGTTTTTAAGAAAAAAATTCTGTGCAGATCTGTTCCTCCTCCTGCTCCTTCCCTTTTCTCTACATACAG
TGCTCATTGGAGGCTCCTGCTAAACCTTCTTAACCAGAGAAATAATAGGTATTTGTTAGACCTGAGTGTACATTTCACATGTTATCCTTC
ACATATTTCTCATTTTCATCTAGTACTTTCTTAATGCCTTTGTTGGAGTCCGCATCCTCATCTTTAAAAAAAAAAAAAAAAAAACAGCTT
AGCCTAAGCCACATTCACTTTTTTTAGTTCACAAAAAGGATTTAATAGCCACAATGTGATTTTTGCCACAACTGTGTGATTTTAATATTC
TCTAATATCAAGGGCGGATTTAGAATTGCAGGAAATACCTGGAGAAATCACAGTGGAATGAATTTTTGCTTTAAGAGAAATGAGAGTTGG
CTGTCTCTGTAATTGATAATACAGCTTCATCCTAGTCCCATCTGCATTTCAGAAAATAACCCTCATCTTTACAAAACACAGGACACTTGT
GGGACAGTTAACTCAAGCAGCTATGGGGAGGGAGGAGATTATTGAATGGTGATTAAATAATGCAAATGGCTCTTCTGTTTCTTAAAGACT
GTGGAAGAGGTCAGACTGCCCAGTTGAGGTGGGCAGTTCATACTGCTCAGTTGAGGTGGCAGTCATTTATTCTGAGTCCTGTTGGATAGA
GCCTATCTCCTCAAGGCTACAGAGGCTTCCAGGATATGGAGCTGTGCATGTTAATGGCTCAGCCTTGCCTCCATCAGGGCACCTGCCTAA
CTTGGAGCAAGTGGGAGAGCACCCTAGAGTCATCCTCTGTGCTGTTTCGTGAGTTTTGCAGCGGAGACTTCACCATCCGGAGGAGCTGTG
TTTCTGTGTCACTTGGGATATCACCTAAAAATGAAACATTTGATATTTTAAGGTATAAAAAAAAAGTAAATTGGGGAACATTGGCTGCAG
TCCCTAAAAGATACTGTTGTCTGTGCATCAGGTTAGCTTGAGGTCACCACAGGTCCTGGGAGCCCAGAGAGTTTAGGCATACTCTCCTTT
GGAGGCCAGCAGCCTTTCACAAACCCTGCCTCTAAAAGGGCGGTTTCACATTTGACCATGTTTTTGCATTAGCCTCAGAAACTCTTGTCT
TTAGCTGATAACCTTTGAGGGATGTGAGAAGCCTAGTTGGAGCATCTGAGAAAATGATACCTCTCACCTTCAAATTAATCAAATAGTTTG
TCCTTCTAGTCCCCTTATAAATTAATAAATGGAGGGCTGGTCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGG
TGGATCACAAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTAGT
GGCACGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGATGTTGCAGTGAGCCGAGATCC
CGCCACTGCACTGCAGCCTAGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGGGAAGGGAATCCCATTTTGT
GATGATTTGGGCACACTACTTGAGCTGAGGCTAGCAGTCACATGATTTTGGCTGTCTCTGACCTGAAGCTTTTGAAGTAAGGTTATGTCT
CTTCCCTGAAGCTTTGTTTATAGTGGTAATTTGGTGAGTTTGAGCTTTGAGCTTGTCTTAGAAAATAAGACTGTCCACCTGGGGAGGGGA
GCTTATAGGGAACCCGTGTTAACTCAGAATGCTGAAGAAAGTGCTTTTAGCCAACAAAAGTAAGATTACTATCTAGAAGGTGGAAAGAAG
TCATTGCTTCTGTTCCTCCAGCAGTCAGTTGACTCTAGGTTTCCTTTGGTTTATATCCCCAGTTCTTAATACTAAAACTTATTTGACTTC
CTATCAGGAAGCACACAAAAAAAGCGTCATTTAAAACCCTGGATATAGGCTTTAAAGGATACAAAAACAGCAGCATTGTCGTTTTGCCAG
GTTCATCACCATTTTGATGTGCTACCCATCCTTCCACCCTCCCTTTCCTGCCCCCAAGCCTCCCAGCCAGGCCAGATGTGAAGATTCTAT
TAATCACTGTTTCAGAGAACATTAATTCTTGTATAGAATAATTATCTACTAAATTGCTTATTATCTGTGACTACCTTGCAGAGAACATCT
CAACAGTGCAGTAAAATAGCTCTCCTAGACTTGAGCTTCCAGCCAGGCATTTAGATCACTCTTAAGCCTTTGTGGAATTCTGAGGAAAAA
AAGCAAGATGCCTCAATGCCAATGCTGGGCCATAAGATTCTACTCCCCTCCCTGTAGGGTGGGGCGCGTGGCTCAGCTTTGGAAAATCAT
TTTGCCAGTAATATTGCCTGTGAATCCCTTTAAGAAGTCGTCCTGATCTGAGCCTGTCTTTCTGAGCACTTTGGTGCTGAATTGAAAATG
GTAAGCTAAAGCAGTGACAGATCCACGTAGCCTCTTTAACCTCTTTATTATCTTGCCAAAAAAAAAGTTTCTCAGGTTAAACCTTTGTCT
TTAACCTCCCTTTGTTGTGGAGAAAATGTGTCACTAATCAGTGGTCCAAGGGATATCTAGCTTTGGTTACTCAGTTCCTGCAGCATAACA
GATATGACTTATGCCAGGGAAGGTAGAGGCTGATTATGGAGACACCCAGGAACAGGAATAAGAAGGGATAGGTCTGCTCCACGTAGAACC
TCCCCAGATCGGAAGTTAAGTCTTGGAGAGTTTCCAAAGTGCTGAAGTAAAAAGGAGACTTGGAGGGCCTTTGCTTAATGAGCAAGAGGC
TTGTGTCCTCCCAAGAACATGAGGGAGTTCAGAAGGGAGCTATAGCTCACAGACAGAAACCTGCCCGCTCACCCCATCCCTCGTGACTGG
GAGCATGTTTGCTCAGAATTTTCTAAGAGGACTCTCCCTTCAAAAATCCAATTTGCTCCCAGAATGTTGTTTAGCCTCTGAGAATCTCAC
TCTTTCATTTCCATCTGTGAATGGACATAGATGTGTTGCTCAGGGATCAGAAACATCAGAGTCCAGGGCCCAGTGGCATGGTGTTGCATT
AGTAGTTAGAAAAGTAATTGGTCAGCTCTACTGTAAAAGAAATAAGTATGTAGTACAGTTTTGTAAATGTCAGGTCTGTTCTATTGTTTT
GTGATCTGAAGACTGTCAAACTGGTTGATAATCAAAGAAAAGGTTGGTGGTTAGAATAAGTAAAATTTCAGTTAGAAAGATATAGCTTAC
CAGTTTTCCATGTGCTTAAGGAAGTCAAGAATATTTCAGGTTGTTGAGAACTGTTGTAAAATGGAATTGAAGCTAGTGTCTCTCACCTTC
TTAGGTGTATCAGAGAGAGGAAGTGGAAGGCCAGTAGTAGCATCTTCATACTTACTTTTGCCAGCCCAGCCTCCATTTCAAAGACTTTGT
CTTCCATCCTATCCAATGACATGGTCAGGGATGGGCTCTGAGGAGGCAGTGAGGCCCCACCTTGGTTTGCTCCACTGTGGTGTGTAGTCT
CCAAACAGCTTAAGGGTTTTTAAGTTTTCTCACGATTACCTCCACTCCACTCATCTACTATCAGCATCAGAAAGGTTAACATCCCTGGGA
CCATTCTACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAATCTCCTCTTGGCCAAGTTCA
ACAAATGTTTCCAGGGAACCCCGTGGGTTGAGGCAAAGTAGCCAAGATGTATTGAGTTAAGTTTTTCTAGAGGACAAAAGTATTTCTTGT
CCCTTTTCCCTCATGCTCATATGTTTTAGCTGAGGCGTAAATGGCCAAGTTGAGTAATATCTGTGGAACTGAGACAGAGAGCCAGGGACC
CATGTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTATCCCACCAGAACTCTGCTGCTGTTCATTTC
CATCAGGACCACCCAGGAAAGCAAATAAGTTAGCCTTCTCATCATTAGGTCACCTAATCTCTTGGGTTGCAGGATGAGAGCATATATAGA
TCTCCTGTTTAGAGAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAATAACCAAGAGGCTGTGTCATTTTTTAAGAGGATGGCAA
GGATGACCTCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTGTGGTCCTTAAACCTCTT
GGCACCTTGTGCGGGTTATAAAACAAGGAGCTGGAGTAAAATTGCCCTTACCCCCAATCCAAATGCTGTCCAGGATTTAGGAGCTACCCA
ACCTGTGGTTATATGGTGTTGGTTTCCATTTTTTGTTTGTTTGCTTGTTTCCAAAATAGCCTTGCTTGGTACTGCATGGAAAGTTCAAGC
TTTTCTTCTTGCCCGCTCAGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTCCCTAAGGAAGATTTTTGCAGCACTCTCTGGAGCTGAGG
GGAGTGAAATTTGGTCCAGAGAAGGCGGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGTGGATGTCCTCAGGCTTCCTTCACACCT
CCTTCTCATGGGTGCGGCTGGCAGTACAGTCAGGCTGTGGAGGAGGGCTGAGAAGAAAGGGGCACTGGTCCAGCCCCAGGTTTGGTCTGA
GACAGGTACACAGCAGATACCATCCCACCTTCCTCTCTAAAGAACAGGCCAGCCACACATATAACCCTTTCCCTACTTTACTAATGTATC
CCTTATGTGGTACCAGCAATGGAGGACAGGCAGACTTACCCCCTGCCATCTAGAGAGAATGTTGTTATTACCCGTAAAACTTGACCACCC
CCATATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCGTTCCTTTCTATGTGTTAATCAGTTTCCTTCCATTTGA

>In-frame_CLIC1_ENST00000395892_chr6_31701343_-_NUDT3_ENST00000607016_chr6_34263462_-_9975nt
GGATTTGATTGGCGCAGTGGGAAGCCCGCGAGAAGAGGTGGAAGCATTCGAATTACATCAAATTCTGGCAGAGAGAAGTAGTTCTGATCA
GAACACTCACACCCCTACTGGGACATGCCCATACCCCTTCGCACTTCTACACACCCCTGAAGACAGAGAGCCCCTCCCAGTTCCCCCAGG
GACGGCCACTTCCTGGTCCCCGACGCAACCATGGCTGAAGAACAACCGCAGGTCGAATTGTTCGTGAAGGCTGGCAGTGATGGGGCCAAG
ATTGGGAACTGCCCATTCTCCCAGAGACTGTTCATGGTACTGTGGCTCAAGGGAGTCACCTTCAATGTTACCACCGTTGACACCAAAAGG
CGGACCGAGACAGTGCAGAAGCTGTGCCCAGGGGGGCAGCTCCCATTCCTGCTGTATGGCACTGAAGTGCACACAGACACCAACAAGATT
GAGGAATTTCTGGAGGCAGTGCTGTGCCCTCCCAGGTACCCCAAGCTGGCAGCTCTGAACCCTGAGTCCAACACAGCTGGGCTGGACATA
TTTGCCAAATTTTCTGCCTACATCAAGAATTCAAACCCAGCACTCAATGACAGCTGGAGTAAAAGGGACATTGGGAAGATTAGTTGGAAT
TTTTGAGAACCAGGAGAGGAAGCACAGGACGTATGTCTATGTGCTCATTGTCACTGAAGTGCTGGAAGACTGGGAAGATTCAGTTAACAT
TGGAAGGAAGAGGGAATGGTTTAAAATAGAAGACGCCATAAAAGTGCTGCAGTATCACAAACCCGTGCAGGCATCATATTTTGAAACATT
GAGGCAAGGCTACTCAGCCAACAATGGCACCCCAGTCGTGGCCACCACATACTCGGTTTCTGCTCAGAGCTCGATGTCAGGCATCAGATG
ACTGAAGACTTCCTGTAAGAGAAATGGAAATTGGAAACTAGACTGAAGTGCAAATCTTCCCTCTCACCCTGGCTCTTTCCACTTCTCACA
GGCCTCCTCTTTCAAATAAGGCATGGTGGGCAGCAAAGAAAGGGTGTATTGATAATGTTGCTGTTTGGTGTTAAGTGATGGGGCTTTTTC
TTCTGTTTTTATTGAGGGTGGGGGTTGGGTGTGTAATTTGTAAGTACTTTTGTGCATGATCTGTCCCTCCCTCTTCCCACCCCTGCAGTC
CTCTGAAGAGAGGCCAACAGCCTTCCCCTGCCTTGGATTCTGAAGTGTTCCTGTTTGTCTTATCCTGGCCCTGGCCAGACGTTTTCTTTG
ATTTTTAATTTTTTTTTTTTATTAAAAGATACCAGTATGAGATGAAAACTTCCAATAATTTGTCCTATAATGTGCTGTACAGTTCAGTAG
AGTGGTCACTTTCACTGCAGTATACATTTATCTACACATTATATATCGGACATATAATATGTAAATAAATGACTTCTAGAAAGAGAAATT
TGTTTAATTTTTCAAGGTTTTTTTCTCTTTTAATTTGGGCATTTCTAGAATTGAGAGCCTCACAATTAACATACCTTTTTGTTTTCGATG
CTAGTGGCTGGGCAGGTTGCCCTGTCCTTTCTCTATTTCCCAGTCATTGACTGTAGATATGGGAAGAGTTTAGCTACCTTCATAGTGCTC
CCAGGACTCATGGCCTTTCCTTCTTTAAGCTGTATTTCCCTGCCCAGAAAGAAACAGGAAGAAACCTTTTTTTATTTTTTTATTTTTTTT
TAACCAAGCAAGGAGCAAATGGCCTCAGCCCAGATCTGTAAAAACAATGATAGAAATTGAATTCTGCCCCACATGTTGACAGTAGAGTTG
GAACTGGATTCTTGGGATTACTTATCTAAAAAACTGGAGCATCAGGTCCATTTCTGTTCTGCTGGTTTGGAATCTTTTCCGTAATGCTAT
TTATTGCCAACAATGGCCTCTCTTTGTGTCCATATATGCCTTACACCGTGCTGACCTGGGTATCATCCATGTGCTCTGAAGCATCCAACT
TTACTTTGCAGGTGCATCAATGTAGTCCTGTCCCTGAACTGAGTAACCGTGTTCCTGAAAAGTACACTAGGGAAATTCACCTGCTTGCTT
GTCTTTGTATTGGCATGGCACTTGTGATTGCACCATGGAGCATGCTCAGAGCTATTAAATTGGTCTCCCATCTCCCACCAGGATATGAAA
GGTCCATATGGGAGGCCACGTAATCACTTATTACAGTGGTTACATAATACACTGGCTCACTGCAGACTCTCTTGTTTTTTGATACAGTTT
CGTGCTGGCTTCATTTGCCAATTGTGTTGTTTAGTTCGGAAGTAAGAGGGTCTTGAGATTGAGGGGTAGGGAGGGCTACACTGACTGATC
CGTGGCTTAAGACAGGAGATTATCTCTGTACTCCAGTGGCATCTCCTTAGCCAAGATGTGAAATTAAAATCATAGTTCGCCTCATTTAAA
AATTCTAATAAAGCACTCAAACTTTGAAAAGCTTTTACTTTTCCCTCCTACTAAAAGAAATGTATGTACCTCATAGCCCTGTGTCATTTA
GTGTTCAGCACTTTTGGGAACATCAGTTGGTGAACTTTAAATTTTGCTGTCTACTCACTGGGCACGGTGGCTCACACCTGTAATCCCAGC
ACTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGACCAACATGGTGAAACCCCGTCTCTACTAAAAA
TGCAGAAATTAGGTGGGCGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCGAGATAATCGCTTGAACCTGGGAGGCAGAGGTTGCAGTG
AGCCGAGATTGCACCACTGTCGTCCAGCCTGGGTGATAAGAGTGAAACTCCATCTCAAAAAAAAAAAAAAAAAATTTTTTTTTTTTTTTT
TGCTATATACTCTTAGTTTACATCCTCTCCCCCAATCTTCACACACAGAGCCAAAGAGCAGTTATATTCTTGGGATACCATGATACCTCT
GGGAAAGGAATTATATTCCCAAGGAGAGGTCCCATTGGATAAGAACAATACCATGGGACTTGAGTCTGAATGCCAACTTACTATTCACAC
ATCCTTCTTAAAAACGAACACACTGTTTCTTTTCCTGACCTAGAGCATTCTAAAGTTCTGTTCAAATAAATAAAGGGCAAAATAAAGTAG
ATTTAACCAAGTGCCAGGTGGAATTCAAAAAACACATTCTTCCAGATAAATTCTACCTTTATGGTATGGATTTGAAAGTACTTTGCAGGA
AAACAGTCAGTACTCTTTAAAAAGGGACTGCAGGGCTGGGTGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGGT
GGGTCACTTGAGGCCAGGAGTTTGAGACCAGCCTGACCAACATGGCAAAACCCCATCTCTACTAAAATACAAAAATTAGCTGGGCATGAT
GGTGCACTCCTGTAATCCCAGCTACTTGGTAGGCTGAAGCATGAGAATTGCTTAAACCTGGGAGGCAGAGGTTGCAGTAAGCCAAGATCA
TGCCACTGCACTCCAGCCTGGGCAACAGAGTAAGACTCTGTCTTAATAAATAAATAAGAAAATAAAACGGAACTGCAGTGCTAACAGTAA
TTTATACATTTTTAAATGTTCTGAGTATGTTTTGACTGGGCTAGTGTAACAATATACTACCCTGAAAGTGCAGTTTTGATTGTTGTTGGT
GTCTTTGGGTCAGGAAAGTGAACTGTGCCAAGAAGTATTTTTCAGTGACATGAATGGATTCCTGTTAATGCAATTGACTGAGAGATTGTG
CTTACGCTTTCTTAACTGACAAAAAGAGGCTTTGTCCAACATCAGAATTGTTGAAACTGGTGCTGTTTTCTGTTGCACTGGGATTCTGAT
GATCTGGGATTTTCCCTCCTTGGCACAGTAAACACCATGACTGTCTTTATTGAGAATGTCGTCACAGTCCTTTAGTGATAGATTAGTTAG
ACCCATGGTTGCAATACCTTTATCTCCCCAAAGAAAATAATCAAAAGAAAGCACAAAAGCTACCCTGTTTGCAGAATATTTCACTGACAT
TGATTTGTCATTAATTCTACCAGAGCTGACCTCATTCAGGCTTGATAGAAACAGGTTCCTATGTTTAGGGCAGATCCCTAGCCTCTCGCT
CACAGTGAGTCTGCATGTCCTAGATTCTGGTTATTGCTGGAGCATCCATTAAAGTCTACCAAACTCAGGACAGAAGAAGATAGCAGTGGA
TTTGTAAAAATTTTTAGTTTATAAATTACAGTCATTGGGGAAACACTAGTAAGGTCATGTGATCTTTTGGACCAGGATTTTCTCTCTGTC
TTCTCTCTGGGTGTGTGTGTGTGTATGTACAGAAGGGCTACCAGGAAGTGTCAACCATGTTAGATTTTCTGTAGTCTTCCAGAAACAGTG
CAGCCCATACAACAGGAATCTTAATTTTCCTCACAGCAAATATAACAGGATGGAACAGTTAGTGTTTTGTTTTCACAAGTGTCCACCACT
CCATCTGCCCTGCATGGAGAGGGCTCTCTCACTGCTAGATCTAGGCTGAGCCATCTGGAAGGATCAAAGGGTGTGGGAGTATCACCCCCT
CTCAGGCTGCAGAAGGTCTCGAGGGTGGCGTCACAGCAGGATTTCCGCCTTCTGCATTGCACTGCACAGCCCCATGGAACATGAGGCACT
TGAGGCCTTGCTTCTTGGAGCCTCTGGGGAGCAGAGTAGGTCACTGCCCTCTGGGAGTGTTTTGCAGTAGTTTTGTAAATGTGTTGCTAC
ATAGTCAAGTTCCTTTGTGGCAAAGAAATATTTTGTTTTGATATTAGGAGCCAGCCCATGTAATGCCTCTCAGGCTTGCTTGCTTAGAAG
AAAAAAGTCACCCTTTGTGGTTTTTAAGAAAAAAATTCTGTGCAGATCTGTTCCTCCTCCTGCTCCTTCCCTTTTCTCTACATACAGTGC
TCATTGGAGGCTCCTGCTAAACCTTCTTAACCAGAGAAATAATAGGTATTTGTTAGACCTGAGTGTACATTTCACATGTTATCCTTCACA
TATTTCTCATTTTCATCTAGTACTTTCTTAATGCCTTTGTTGGAGTCCGCATCCTCATCTTTAAAAAAAAAAAAAAAAAAACAGCTTAGC
CTAAGCCACATTCACTTTTTTTAGTTCACAAAAAGGATTTAATAGCCACAATGTGATTTTTGCCACAACTGTGTGATTTTAATATTCTCT
AATATCAAGGGCGGATTTAGAATTGCAGGAAATACCTGGAGAAATCACAGTGGAATGAATTTTTGCTTTAAGAGAAATGAGAGTTGGCTG
TCTCTGTAATTGATAATACAGCTTCATCCTAGTCCCATCTGCATTTCAGAAAATAACCCTCATCTTTACAAAACACAGGACACTTGTGGG
ACAGTTAACTCAAGCAGCTATGGGGAGGGAGGAGATTATTGAATGGTGATTAAATAATGCAAATGGCTCTTCTGTTTCTTAAAGACTGTG
GAAGAGGTCAGACTGCCCAGTTGAGGTGGGCAGTTCATACTGCTCAGTTGAGGTGGCAGTCATTTATTCTGAGTCCTGTTGGATAGAGCC
TATCTCCTCAAGGCTACAGAGGCTTCCAGGATATGGAGCTGTGCATGTTAATGGCTCAGCCTTGCCTCCATCAGGGCACCTGCCTAACTT
GGAGCAAGTGGGAGAGCACCCTAGAGTCATCCTCTGTGCTGTTTCGTGAGTTTTGCAGCGGAGACTTCACCATCCGGAGGAGCTGTGTTT
CTGTGTCACTTGGGATATCACCTAAAAATGAAACATTTGATATTTTAAGGTATAAAAAAAAAGTAAATTGGGGAACATTGGCTGCAGTCC
CTAAAAGATACTGTTGTCTGTGCATCAGGTTAGCTTGAGGTCACCACAGGTCCTGGGAGCCCAGAGAGTTTAGGCATACTCTCCTTTGGA
GGCCAGCAGCCTTTCACAAACCCTGCCTCTAAAAGGGCGGTTTCACATTTGACCATGTTTTTGCATTAGCCTCAGAAACTCTTGTCTTTA
GCTGATAACCTTTGAGGGATGTGAGAAGCCTAGTTGGAGCATCTGAGAAAATGATACCTCTCACCTTCAAATTAATCAAATAGTTTGTCC
TTCTAGTCCCCTTATAAATTAATAAATGGAGGGCTGGTCATGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGTGG
ATCACAAGGTCAGGAGTTCAAGACCAGCCTGACCAATATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAGGTGTAGTGGC
ACGCTCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGTGGATGTTGCAGTGAGCCGAGATCCCGC
CACTGCACTGCAGCCTAGGCGACAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAGAAAAGGGAAGGGAATCCCATTTTGTGAT
GATTTGGGCACACTACTTGAGCTGAGGCTAGCAGTCACATGATTTTGGCTGTCTCTGACCTGAAGCTTTTGAAGTAAGGTTATGTCTCTT
CCCTGAAGCTTTGTTTATAGTGGTAATTTGGTGAGTTTGAGCTTTGAGCTTGTCTTAGAAAATAAGACTGTCCACCTGGGGAGGGGAGCT
TATAGGGAACCCGTGTTAACTCAGAATGCTGAAGAAAGTGCTTTTAGCCAACAAAAGTAAGATTACTATCTAGAAGGTGGAAAGAAGTCA
TTGCTTCTGTTCCTCCAGCAGTCAGTTGACTCTAGGTTTCCTTTGGTTTATATCCCCAGTTCTTAATACTAAAACTTATTTGACTTCCTA
TCAGGAAGCACACAAAAAAAGCGTCATTTAAAACCCTGGATATAGGCTTTAAAGGATACAAAAACAGCAGCATTGTCGTTTTGCCAGGTT
CATCACCATTTTGATGTGCTACCCATCCTTCCACCCTCCCTTTCCTGCCCCCAAGCCTCCCAGCCAGGCCAGATGTGAAGATTCTATTAA
TCACTGTTTCAGAGAACATTAATTCTTGTATAGAATAATTATCTACTAAATTGCTTATTATCTGTGACTACCTTGCAGAGAACATCTCAA
CAGTGCAGTAAAATAGCTCTCCTAGACTTGAGCTTCCAGCCAGGCATTTAGATCACTCTTAAGCCTTTGTGGAATTCTGAGGAAAAAAAG
CAAGATGCCTCAATGCCAATGCTGGGCCATAAGATTCTACTCCCCTCCCTGTAGGGTGGGGCGCGTGGCTCAGCTTTGGAAAATCATTTT
GCCAGTAATATTGCCTGTGAATCCCTTTAAGAAGTCGTCCTGATCTGAGCCTGTCTTTCTGAGCACTTTGGTGCTGAATTGAAAATGGTA
AGCTAAAGCAGTGACAGATCCACGTAGCCTCTTTAACCTCTTTATTATCTTGCCAAAAAAAAAGTTTCTCAGGTTAAACCTTTGTCTTTA
ACCTCCCTTTGTTGTGGAGAAAATGTGTCACTAATCAGTGGTCCAAGGGATATCTAGCTTTGGTTACTCAGTTCCTGCAGCATAACAGAT
ATGACTTATGCCAGGGAAGGTAGAGGCTGATTATGGAGACACCCAGGAACAGGAATAAGAAGGGATAGGTCTGCTCCACGTAGAACCTCC
CCAGATCGGAAGTTAAGTCTTGGAGAGTTTCCAAAGTGCTGAAGTAAAAAGGAGACTTGGAGGGCCTTTGCTTAATGAGCAAGAGGCTTG
TGTCCTCCCAAGAACATGAGGGAGTTCAGAAGGGAGCTATAGCTCACAGACAGAAACCTGCCCGCTCACCCCATCCCTCGTGACTGGGAG
CATGTTTGCTCAGAATTTTCTAAGAGGACTCTCCCTTCAAAAATCCAATTTGCTCCCAGAATGTTGTTTAGCCTCTGAGAATCTCACTCT
TTCATTTCCATCTGTGAATGGACATAGATGTGTTGCTCAGGGATCAGAAACATCAGAGTCCAGGGCCCAGTGGCATGGTGTTGCATTAGT
AGTTAGAAAAGTAATTGGTCAGCTCTACTGTAAAAGAAATAAGTATGTAGTACAGTTTTGTAAATGTCAGGTCTGTTCTATTGTTTTGTG
ATCTGAAGACTGTCAAACTGGTTGATAATCAAAGAAAAGGTTGGTGGTTAGAATAAGTAAAATTTCAGTTAGAAAGATATAGCTTACCAG
TTTTCCATGTGCTTAAGGAAGTCAAGAATATTTCAGGTTGTTGAGAACTGTTGTAAAATGGAATTGAAGCTAGTGTCTCTCACCTTCTTA
GGTGTATCAGAGAGAGGAAGTGGAAGGCCAGTAGTAGCATCTTCATACTTACTTTTGCCAGCCCAGCCTCCATTTCAAAGACTTTGTCTT
CCATCCTATCCAATGACATGGTCAGGGATGGGCTCTGAGGAGGCAGTGAGGCCCCACCTTGGTTTGCTCCACTGTGGTGTGTAGTCTCCA
AACAGCTTAAGGGTTTTTAAGTTTTCTCACGATTACCTCCACTCCACTCATCTACTATCAGCATCAGAAAGGTTAACATCCCTGGGACCA
TTCTACTTATAAAAGAGATGAACTAGTGTGCTTTCTCCCCTTTTCCAGGTGTGCCATCCATATACAATCTCCTCTTGGCCAAGTTCAACA
AATGTTTCCAGGGAACCCCGTGGGTTGAGGCAAAGTAGCCAAGATGTATTGAGTTAAGTTTTTCTAGAGGACAAAAGTATTTCTTGTCCC
TTTTCCCTCATGCTCATATGTTTTAGCTGAGGCGTAAATGGCCAAGTTGAGTAATATCTGTGGAACTGAGACAGAGAGCCAGGGACCCAT
GTACCCAGGGACCAGTCCCCTGGGGAATCACACAGTGGCTCAGACTAGACTGCTCTATCCCACCAGAACTCTGCTGCTGTTCATTTCCAT
CAGGACCACCCAGGAAAGCAAATAAGTTAGCCTTCTCATCATTAGGTCACCTAATCTCTTGGGTTGCAGGATGAGAGCATATATAGATCT
CCTGTTTAGAGAGTGTGTTCATAATTGTAGAAAGGGATAGAAAATGGAATAACCAAGAGGCTGTGTCATTTTTTAAGAGGATGGCAAGGA
TGACCTCAAATGAGCTCAACAAAACTGGGAATCCAAGGAATGGTGCTTGTAGGGAAAGAGAGGTCAGTTGTGGTCCTTAAACCTCTTGGC
ACCTTGTGCGGGTTATAAAACAAGGAGCTGGAGTAAAATTGCCCTTACCCCCAATCCAAATGCTGTCCAGGATTTAGGAGCTACCCAACC
TGTGGTTATATGGTGTTGGTTTCCATTTTTTGTTTGTTTGCTTGTTTCCAAAATAGCCTTGCTTGGTACTGCATGGAAAGTTCAAGCTTT
TCTTCTTGCCCGCTCAGGGCTGGCCTCTTCCCCGTGTCTTCACAGCGTCCCTAAGGAAGATTTTTGCAGCACTCTCTGGAGCTGAGGGGA
GTGAAATTTGGTCCAGAGAAGGCGGAAGGAAATAGTTTTCCTGTTTCCTTTTCTCGAGGTGGATGTCCTCAGGCTTCCTTCACACCTCCT
TCTCATGGGTGCGGCTGGCAGTACAGTCAGGCTGTGGAGGAGGGCTGAGAAGAAAGGGGCACTGGTCCAGCCCCAGGTTTGGTCTGAGAC
AGGTACACAGCAGATACCATCCCACCTTCCTCTCTAAAGAACAGGCCAGCCACACATATAACCCTTTCCCTACTTTACTAATGTATCCCT
TATGTGGTACCAGCAATGGAGGACAGGCAGACTTACCCCCTGCCATCTAGAGAGAATGTTGTTATTACCCGTAAAACTTGACCACCCCCA
TATCCCACTCCTTTTTGTAAAAACAAATGCTTAAACCTGTGAGCCTGCCGTTCCTTTCTATGTGTTAATCAGTTTCCTTCCATTTGAGCT


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FusionGenePPI for CLIC1_NUDT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLIC1LSM1, TRAPPC2, AKAP9, ARRB2, ISG15, CDK2, MYOC, GRK5, FN1, VCAM1, ATF2, ITGA4, ATP5F1, CPT1A, NTF4, RPLP1, THRA, ZNF184, IKBKG, PRDX4, NUP62, ZNF302, ALOX5AP, ATP6V0C, ATP6V0A1, FBXO6, PSMD10, CUL7, COG3, FRA10AC1, HIBCH, HSD17B10, MTHFD2, PSMA1, PSMA5, RDX, ST13, TAGLN3, DDB1, SEPHS1, NTRK1, EWSR1, CAPZA2, PPP1CC, IQGAP1, SLC33A1, SYNPO, ANLN, MYO5C, U2AF2, CDH1, TPRN, PROSER2, SDF2L1, CCND2, BRCA1NUDT3SOX30, ASB13, RAB17, RPL8, RPLP1, TNNT3, TUBGCP4, WDR74, ITFG1, FXYD3, RNF126, OAT, DDR1, EEF1G, PDCD5, REEP5, VPS51, PRKD3, RPL17, UBR1, MCM5, ARL6IP1, NUDT5, NR2C1, DBN1, HES1, APEX1, TUBA1A, MEX3B, DNAJA1, CHCHD3, PEX5, ALAS1, XPNPEP1, MAF1, CCL11, ELAVL1, IQCB1, MOV10, NXF1, AP1S2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLIC1_NUDT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCLIC1O00299DB11638ArtenimolChloride intracellular channel protein 1small moleculeapproved|investigational

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RelatedDiseases for CLIC1_NUDT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLIC1C0019693HIV Infections1CTD_human
HgeneCLIC1C0022548Keloid1CTD_human
HgeneCLIC1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCLIC1C0027627Neoplasm Metastasis1CTD_human
HgeneCLIC1C0029408Degenerative polyarthritis1CTD_human
HgeneCLIC1C0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCLIC1C1458155Mammary Neoplasms1CTD_human