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Fusion gene ID: 7380 |
FusionGeneSummary for CLIC1_HIST1H2BC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CLIC1_HIST1H2BC | Fusion gene ID: 7380 | Hgene | Tgene | Gene symbol | CLIC1 | HIST1H2BC | Gene ID | 1192 | 8347 |
| Gene name | chloride intracellular channel 1 | histone cluster 1 H2B family member c | |
| Synonyms | CL1C1|G6|NCC27 | H2B.1|H2B/l|H2BFL|dJ221C16.3 | |
| Cytomap | 6p21.33 | 6p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chloride intracellular channel protein 1RNCC proteinchloride channel ABPhRNCCnuclear chloride ion channel 27nuclear chloride ion channel proteinp64CLCPregulatory nuclear chloride ion channel protein | histone H2B type 1-C/E/F/G/IH2B histone family, member Lhistone 1, H2bchistone H2B.1 Ahistone H2B.lhistone cluster 1, H2bc | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00299 | P62807 | |
| Ensembl transtripts involved in fusion gene | ENST00000375784, ENST00000375779, ENST00000375780, ENST00000395892, ENST00000457485, ENST00000423804, ENST00000447369, ENST00000447338, ENST00000422167, ENST00000438708, ENST00000431921, ENST00000415179, ENST00000418285, ENST00000423055, ENST00000442045, ENST00000435242, ENST00000400052, ENST00000383404, ENST00000383405, ENST00000400058, ENST00000456863, ENST00000434202, ENST00000420458, ENST00000433916, ENST00000425464, ENST00000423143, ENST00000438750, ENST00000451546, | ENST00000314332, ENST00000396984, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 2 X 3=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CLIC1 [Title/Abstract] AND HIST1H2BC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CLIC1 | GO:0006821 | chloride transport | 9139710 |
| Tgene | HIST1H2BC | GO:0002227 | innate immune response in mucosa | 12860195 |
| Tgene | HIST1H2BC | GO:0019731 | antibacterial humoral response | 12860195 |
| Tgene | HIST1H2BC | GO:0050830 | defense response to Gram-positive bacterium | 12860195 |
| Tgene | HIST1H2BC | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12860195 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A2LR-01A | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000375784 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-intron | ENST00000375784 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-3UTR | ENST00000375779 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-intron | ENST00000375779 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-3UTR | ENST00000375780 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-intron | ENST00000375780 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-3UTR | ENST00000395892 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| 5CDS-intron | ENST00000395892 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000457485 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000457485 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000423804 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000423804 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000447369 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000447369 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000447338 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000447338 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000422167 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000422167 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000438708 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000438708 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000431921 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000431921 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000415179 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000415179 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000418285 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000418285 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000423055 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000423055 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000442045 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000442045 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000435242 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000435242 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000400052 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000400052 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000383404 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000383404 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000383405 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000383405 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000400058 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000400058 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000456863 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000456863 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000434202 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000434202 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000420458 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000420458 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000433916 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000433916 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000425464 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000425464 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000423143 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000423143 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000438750 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000438750 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-3UTR | ENST00000451546 | ENST00000314332 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
| intron-intron | ENST00000451546 | ENST00000396984 | CLIC1 | chr6 | 31701343 | - | HIST1H2BC | chr6 | 26115363 | - |
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FusionProtFeatures for CLIC1_HIST1H2BC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CLIC1 | HIST1H2BC |
| Can insert into membranes and form chloride ionchannels. Channel activity depends on the pH. Membrane insertionseems to be redox-regulated and may occur only under oxydizingconditions. Involved in regulation of the cell cycle.{ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932,ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526,ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939,ECO:0000269|PubMed:9139710}. | Core component of nucleosome. Nucleosomes wrap andcompact DNA into chromatin, limiting DNA accessibility to thecellular machineries which require DNA as a template. Histonesthereby play a central role in transcription regulation, DNArepair, DNA replication and chromosomal stability. DNAaccessibility is regulated via a complex set of post-translationalmodifications of histones, also called histone code, andnucleosome remodeling. Has broad antibacterial activity. May contribute to theformation of the functional antimicrobial barrier of the colonicepithelium, and to the bactericidal activity of amniotic fluid. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CLIC1_HIST1H2BC |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CLIC1_HIST1H2BC |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CLIC1 | LSM1, TRAPPC2, AKAP9, ARRB2, ISG15, CDK2, MYOC, GRK5, FN1, VCAM1, ATF2, ITGA4, ATP5F1, CPT1A, NTF4, RPLP1, THRA, ZNF184, IKBKG, PRDX4, NUP62, ZNF302, ALOX5AP, ATP6V0C, ATP6V0A1, FBXO6, PSMD10, CUL7, COG3, FRA10AC1, HIBCH, HSD17B10, MTHFD2, PSMA1, PSMA5, RDX, ST13, TAGLN3, DDB1, SEPHS1, NTRK1, EWSR1, CAPZA2, PPP1CC, IQGAP1, SLC33A1, SYNPO, ANLN, MYO5C, U2AF2, CDH1, TPRN, PROSER2, SDF2L1, CCND2, BRCA1 | HIST1H2BC | BCL10, DDX56, PSMD10, VHL, DLG3, NME2, H2AFX, SIRT1, HDGF, EIF4A3, MAGOH, ITGA4, TP53BP2, ESR1, NPM1, TMPO, MEF2A, NFATC1, TRIM29, MCM2, MCM5, PARP1, PARP2, C4orf27, COX15, DLD, SDHA, VDAC1, UBE2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CLIC1_HIST1H2BC |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | CLIC1 | O00299 | DB11638 | Artenimol | Chloride intracellular channel protein 1 | small molecule | approved|investigational |
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RelatedDiseases for CLIC1_HIST1H2BC |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CLIC1 | C0019693 | HIV Infections | 1 | CTD_human |
| Hgene | CLIC1 | C0022548 | Keloid | 1 | CTD_human |
| Hgene | CLIC1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CLIC1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| Hgene | CLIC1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | CLIC1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | CLIC1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | HIST1H2BC | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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