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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7358

FusionGeneSummary for CLEC12B_ANKRD12

check button Fusion gene summary
Fusion gene informationFusion gene name: CLEC12B_ANKRD12
Fusion gene ID: 7358
HgeneTgene
Gene symbol

CLEC12B

ANKRD12

Gene ID

387837

23253

Gene nameC-type lectin domain family 12 member Bankyrin repeat domain 12
SynonymsUNQ5782ANCO-2|ANCO1|GAC-1|Nbla00144
Cytomap

12p13.2

18p11.22

Type of geneprotein-codingprotein-coding
DescriptionC-type lectin domain family 12 member Bmacrophage antigen htestis secretory sperm-binding protein Li 205aankyrin repeat domain-containing protein 12ankyrin repeat-containing cofactor 2
Modification date2018040320180519
UniProtAcc

Q2HXU8

Q6UB98

Ensembl transtripts involved in fusion geneENST00000396502, ENST00000338896, 
ENST00000383440, ENST00000262126, 
ENST00000540578, ENST00000400020, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 6 X 1=30
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/30*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLEC12B [Title/Abstract] AND ANKRD12 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE938624CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000396502ENST00000383440CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-3CDSENST00000396502ENST00000262126CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-intronENST00000396502ENST00000540578CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-intronENST00000396502ENST00000400020CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-3CDSENST00000338896ENST00000383440CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-3CDSENST00000338896ENST00000262126CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-intronENST00000338896ENST00000540578CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+
intron-intronENST00000338896ENST00000400020CLEC12Bchr12

10166676

-ANKRD12chr18

9255824

+

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FusionProtFeatures for CLEC12B_ANKRD12


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLEC12B

Q2HXU8

ANKRD12

Q6UB98

Cell surface receptor that protects target cells againstnatural killer cell-mediated lysis. Modulates signaling cascadesand mediates tyrosine phosphorylation of target MAP kinases.{ECO:0000269|PubMed:17562706}. May recruit HDACs to the p160 coactivators/nuclearreceptor complex to inhibit ligand-dependent transactivation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLEC12B_ANKRD12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLEC12B_ANKRD12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLEC12B_ANKRD12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLEC12B_ANKRD12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource