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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7357

FusionGeneSummary for CLEC12A_CLEC2A

check button Fusion gene summary
Fusion gene informationFusion gene name: CLEC12A_CLEC2A
Fusion gene ID: 7357
HgeneTgene
Gene symbol

CLEC12A

CLEC2A

Gene ID

160364

387836

Gene nameC-type lectin domain family 12 member AC-type lectin domain family 2 member A
SynonymsCD371|CLL-1|CLL1|DCAL-2|MICLINPE5792|KACL|PILAR|UNQ5792
Cytomap

12p13.31

12p13.31

Type of geneprotein-codingprotein-coding
DescriptionC-type lectin domain family 12 member AC-type lectin protein CLL-1C-type lectin-like molecule-1dendritic cell-associated lectin 2myeloid inhibitory C-type lectin-like receptorC-type lectin domain family 2 member Akeratinocyte-associated C-type lectinproliferation-induced lymphocyte-associated receptor
Modification date2018051920180329
UniProtAcc

Q5QGZ9

Q6UVW9

Ensembl transtripts involved in fusion geneENST00000355690, ENST00000304361, 
ENST00000434319, ENST00000350667, 
ENST00000339766, ENST00000455827, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 3 X 4=60
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLEC12A [Title/Abstract] AND CLEC2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7788-01ACLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355690ENST00000339766CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000355690ENST00000455827CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000304361ENST00000339766CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000304361ENST00000455827CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000434319ENST00000339766CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000434319ENST00000455827CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000350667ENST00000339766CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-
Frame-shiftENST00000350667ENST00000455827CLEC12Achr12

10124286

+CLEC2Achr12

10069402

-

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FusionProtFeatures for CLEC12A_CLEC2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLEC12A

Q5QGZ9

CLEC2A

Q6UVW9

Cell surface receptor that modulates signaling cascadesand mediates tyrosine phosphorylation of target MAP kinases.{ECO:0000269|PubMed:14739280, ECO:0000269|PubMed:16239426}. Plays a role in modulating the extent of T-cellexpansion. Enhances the expansion of TCR-stimulated T-cells byincreasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to hometo lymph nodes through SELL. Facilitates dedicated immunerecognition of keratinocytes via interaction with its receptorKLRF2 by stimulating natural killer cell mediated cytotoxicity.{ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLEC12A_CLEC2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLEC12A_CLEC2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CLEC12ABNIP1, STX6, XPO5, COLEC12, STX18, GOSR1, SOX13, STX5, MESDC2, STX10, PBXIP1, TMEM57, ADAMTS2, SNAP47, VAMP4, STX8, GOSR2, VTI1A, IKBIP, TARSL2, VTI1B, MAN2A2, GAS6, SUN1, DNAJC1, APP, LRP11CLEC2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLEC12A_CLEC2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLEC12A_CLEC2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLEC12AC0003873Rheumatoid Arthritis1CTD_human