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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7355

FusionGeneSummary for CLDND1_CLDND1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLDND1_CLDND1
Fusion gene ID: 7355
HgeneTgene
Gene symbol

CLDND1

CLDND1

Gene ID

56650

56650

Gene nameclaudin domain containing 1claudin domain containing 1
SynonymsC3orf4|GENX-3745|Z38C3orf4|GENX-3745|Z38
Cytomap

3q11.2

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionclaudin domain-containing protein 1claudin domain containing 1 proteinmembrane protein GENX-3745claudin domain-containing protein 1claudin domain containing 1 proteinmembrane protein GENX-3745
Modification date2018051920180519
UniProtAcc

Q9NY35

Q9NY35

Ensembl transtripts involved in fusion geneENST00000502288, ENST00000507874, 
ENST00000341181, ENST00000437922, 
ENST00000394180, ENST00000503004, 
ENST00000394185, ENST00000394181, 
ENST00000510545, ENST00000511081, 
ENST00000513287, ENST00000508503, 
ENST00000502288, ENST00000507874, 
ENST00000341181, ENST00000437922, 
ENST00000394180, ENST00000503004, 
ENST00000394185, ENST00000394181, 
ENST00000510545, ENST00000511081, 
ENST00000513287, ENST00000508503, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 1=4
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/4*10)=2.32192809488736
Context

PubMed: CLDND1 [Title/Abstract] AND CLDND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA665142CLDND1chr3

98235895

-CLDND1chr3

98235785

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000502288ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000502288ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000507874ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000341181ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000437922ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394180ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000503004ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394185ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000394181ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000510545ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000511081ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
5CDS-intronENST00000513287ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000502288CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000507874CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000341181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000437922CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000394180CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000503004CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000394185CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000394181CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000510545CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000511081CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000513287CLDND1chr3

98235895

-CLDND1chr3

98235785

+
intron-intronENST00000508503ENST00000508503CLDND1chr3

98235895

-CLDND1chr3

98235785

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Top

FusionProtFeatures for CLDND1_CLDND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLDND1

Q9NY35

CLDND1

Q9NY35


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLDND1_CLDND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLDND1_CLDND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLDND1_CLDND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLDND1_CLDND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource