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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7348

FusionGeneSummary for CLDN4_MUC4

check button Fusion gene summary
Fusion gene informationFusion gene name: CLDN4_MUC4
Fusion gene ID: 7348
HgeneTgene
Gene symbol

CLDN4

MUC4

Gene ID

1364

4585

Gene nameclaudin 4mucin 4, cell surface associated
SynonymsCPE-R|CPER|CPETR|CPETR1|WBSCR8|hCPE-RASGP|HSA276359|MUC-4
Cytomap

7q11.23

3q29

Type of geneprotein-codingprotein-coding
Descriptionclaudin-4CPE-receptorClostridium perfringens enterotoxin receptor 1Williams-Beuren syndrome chromosomal region 8 proteinmucin-4ascites sialoglycoproteinmucin 4, tracheobronchialpancreatic adenocarcinoma mucintestis mucintracheobronchial mucin
Modification date2018052720180522
UniProtAcc

O14493

Q99102

Ensembl transtripts involved in fusion geneENST00000466411, ENST00000435050, 
ENST00000431918, ENST00000340958, 
ENST00000346145, ENST00000349607, 
ENST00000463781, ENST00000475231, 
ENST00000478685, 
Fusion gene scores* DoF score4 X 4 X 2=325 X 5 X 1=25
# samples 46
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/25*10)=1.26303440583379
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CLDN4 [Title/Abstract] AND MUC4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG984966CLDN4chr7

73245980

+MUC4chr3

195516593

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000466411ENST00000346145CLDN4chr7

73245980

+MUC4chr3

195516593

-
intron-intronENST00000466411ENST00000349607CLDN4chr7

73245980

+MUC4chr3

195516593

-
intron-intronENST00000466411ENST00000463781CLDN4chr7

73245980

+MUC4chr3

195516593

-
intron-intronENST00000466411ENST00000475231CLDN4chr7

73245980

+MUC4chr3

195516593

-
intron-intronENST00000466411ENST00000478685CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000435050ENST00000346145CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000435050ENST00000349607CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000435050ENST00000463781CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000435050ENST00000475231CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000435050ENST00000478685CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000431918ENST00000346145CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000431918ENST00000349607CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000431918ENST00000463781CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000431918ENST00000475231CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000431918ENST00000478685CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000340958ENST00000346145CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000340958ENST00000349607CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000340958ENST00000463781CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000340958ENST00000475231CLDN4chr7

73245980

+MUC4chr3

195516593

-
5CDS-intronENST00000340958ENST00000478685CLDN4chr7

73245980

+MUC4chr3

195516593

-

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FusionProtFeatures for CLDN4_MUC4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CLDN4

O14493

MUC4

Q99102

Channel-forming tight junction protein that mediatesparacellular chloride transport in the kidney. Plays a criticalrole in the paracellular reabsorption of filtered chloride in thekidney collecting ducts. Claudins play a major role in tightjunction-specific obliteration of the intercellular space, throughcalcium-independent cell-adhesion activity.{ECO:0000250|UniProtKB:O35054}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CLDN4_MUC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CLDN4_MUC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CLDN4_MUC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CLDN4_MUC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCLDN4C0027643Neoplasm Recurrence, Local1CTD_human
HgeneCLDN4C0032460Polycystic Ovary Syndrome1CTD_human
HgeneCLDN4C1134719Invasive Ductal Breast Carcinoma1CTD_human
HgeneCLDN4C1458155Mammary Neoplasms1CTD_human
TgeneMUC4C0000786Spontaneous abortion1CTD_human
TgeneMUC4C0007134Renal Cell Carcinoma1CTD_human
TgeneMUC4C0033578Prostatic Neoplasms1CTD_human