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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7294

FusionGeneSummary for CKS1B_SHC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CKS1B_SHC1
Fusion gene ID: 7294
HgeneTgene
Gene symbol

CKS1B

SHC1

Gene ID

1163

6464

Gene nameCDC28 protein kinase regulatory subunit 1BSHC adaptor protein 1
SynonymsCKS1|PNAS-16|PNAS-18|ckshs1SHC|SHCA
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinases regulatory subunit 1CDC2-associated protein CKS1CDC28 protein kinase 1BNB4 apoptosis/differentiation related proteincell division control protein CKS1SHC-transforming protein 1SH2 domain protein C1SHC (Src homology 2 domain containing) transforming protein 1SHC-transforming protein 3SHC-transforming protein A
Modification date2018052320180527
UniProtAcc

P61024

P29353

Ensembl transtripts involved in fusion geneENST00000368439, ENST00000368436, 
ENST00000308987, ENST00000471245, 
ENST00000600888, 
ENST00000368445, 
ENST00000368449, ENST00000448116, 
ENST00000368450, ENST00000368453, 
ENST00000606391, ENST00000490667, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 4 X 5=160
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/160*10)=-1.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CKS1B [Title/Abstract] AND SHC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSHC1

GO:0000165

MAPK cascade

14676841

TgeneSHC1

GO:0000187

activation of MAPK activity

14676841

TgeneSHC1

GO:0071363

cellular response to growth factor stimulus

20010870


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12Q-01ACKS1Bchr1

154947280

+SHC1chr1

154938993

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000368439ENST00000368445CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5UTR-3CDSENST00000368439ENST00000368449CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5UTR-3CDSENST00000368439ENST00000448116CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5UTR-3CDSENST00000368439ENST00000368450CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5UTR-3CDSENST00000368439ENST00000368453CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5UTR-3CDSENST00000368439ENST00000606391CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5UTR-intronENST00000368439ENST00000490667CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000368436ENST00000368445CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000368436ENST00000368449CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000368436ENST00000448116CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000368436ENST00000368450CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000368436ENST00000368453CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000368436ENST00000606391CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5CDS-intronENST00000368436ENST00000490667CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000308987ENST00000368445CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000308987ENST00000368449CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000308987ENST00000448116CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000308987ENST00000368450CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000308987ENST00000368453CKS1Bchr1

154947280

+SHC1chr1

154938993

-
In-frameENST00000308987ENST00000606391CKS1Bchr1

154947280

+SHC1chr1

154938993

-
5CDS-intronENST00000308987ENST00000490667CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000471245ENST00000368445CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000471245ENST00000368449CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000471245ENST00000448116CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000471245ENST00000368450CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000471245ENST00000368453CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000471245ENST00000606391CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-intronENST00000471245ENST00000490667CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000600888ENST00000368445CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000600888ENST00000368449CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000600888ENST00000448116CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000600888ENST00000368450CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000600888ENST00000368453CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-3CDSENST00000600888ENST00000606391CKS1Bchr1

154947280

+SHC1chr1

154938993

-
intron-intronENST00000600888ENST00000490667CKS1Bchr1

154947280

+SHC1chr1

154938993

-

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FusionProtFeatures for CKS1B_SHC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CKS1B

P61024

SHC1

P29353

Binds to the catalytic subunit of the cyclin dependentkinases and is essential for their biological function.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CKS1B_SHC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CKS1B_SHC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CKS1BSKP2, CDKN1B, CCNA2, CDK2, DUSP1, COPS6, PSMD9, CDC27, SKP1, CKS1BP7, KIAA0368, FZR1, CDC20, CUL1, COPS5, CCNB1, CDK1, CDK3, LDHB, CCNA1, CCNB2, SSBP1, HSP90AA1, CDC37, CDKN1A, XIAP, CDX4, CKS1B, KRTAP5-9, MEOX1, REL, TRIM27, TCF4, IKZF1, ARID5A, ROPN1, SEPT3, MIPOL1, SPERT, KRTAP10-9, SUMO1P1, TRIM49, GDPGP1, CDT1, GMNN, PKMYT1, CCNE2, CCNE1, ICK, IKZF5, CKS2, EEF1A2SHC1FLT1, DDR2, PTPN12, MAPKAPK2, CALCOCO2, EGFR, ERBB2, ERBB3, ERBB4, PIK3R1, DOK1, DOK2, INPP5D, PLSCR1, LRP1, GRB2, CDH5, KDR, IL2RB, ABL1, INPPL1, CD22, IL4R, PLCG2, ITGB4, PTK2, EPHA2, PLCG1, CBLB, CEACAM1, CSF3R, PRKCD, ALK, FLT4, SOS1, SOS2, RET, CSF2RB, IL2RG, IGF1R, GAB2, SHCBP1, DAG1, NTRK1, ZAP70, PAG1, EPOR, VAV3, CSK, AP2A2, NTRK2, NTRK3, ESR1, APP, NGFR, LYN, CBL, EPS8, PDGFRB, CRKL, RAPGEF1, MAPK1, STAT5A, STAT5B, GH1, JAK2, GHR, MET, PIK3C2B, CALD1, MST1R, DDR1, IL6ST, INSR, FCGR2B, HIF1A, HMOX2, OSGEP, CBLC, NUDT21, MRPL44, ILK, FAM118B, SUV39H2, DUSP23, MAPK6, PRKRA, GEMIN7, C11orf58, CSF1R, LCP2, SH2B2, LRRK1, GAB1, PIK3R2, SPTBN1, SPTAN1, USP9X, AP2A1, KRT1, HSPA8, MYH10, KRT10, KRT9, KRT2, TUBB, TUBB4B, TUBA1B, TUBA1C, TUBA1A, AP2B1, USP9Y, TUBB2B, ACACA, KRT5, ACTN4, HSPA1B, SPTA1, TUBB3, KRT6A, FASN, HSPA5, MYH9, ACTB, CAD, IQGAP1, TUBA8, PSTPIP2, KRT14, MYO1D, HSPA9, HSPA1L, KRT16, ACTA1, TUBB6, HSP90AB1, HSPA6, MYH11, ACLY, RUVBL2, EEF1A1P5, KRT3, UBASH3B, DNM2, HSP90AA1, CRK, RAB3GAP2, MYH14, PRKDC, KRT17, AP2M1, IKBKAP, TUBAL3, RUVBL1, BCR, CORO1C, TIMM50, PRMT5, SEC16A, KRT77, DNAJA2, PPP1R9B, TUBA4B, MYO1C, KRT4, KRT13, DNAJA1, IARS, IGHG1, S100A8, RPS19, ATAD3B, CCT2, AIFM1, VARS, S100A9, HNRNPH1, ARAP1, CLTC, USP15, PRDX1, TEC, DDX5, HAX1, CCT6A, DDB1, S100A7, ANXA2, ERRFI1, MOV10, NXF1, RFFL, CLIC4, MAT1A, PLS3, PSPH, PPP1R8, RMDN1, STXBP1, ARHGAP32, CEP170, SCLT1, XPO1, TRIM15, CDC5L, ACTG1, ARHGEF5, GFAP, HNRNPU, LGALS3BP, SHC1, PRSS3, HSPA1A, HNRNPA2B1, ITGAV, ITGB3, ITGB1, KRAS, LTK, SHC2, OXT, RASAL2, CORO2B, PEAK1, GAREM, CDC25C, AMD1, AP1B1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CKS1B_SHC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCKS1BP61024DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1small moleculeapproved|vet_approved

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RelatedDiseases for CKS1B_SHC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSHC1C0018800Cardiomegaly1CTD_human
TgeneSHC1C1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human