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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 729

FusionGeneSummary for ADAMTS16_ETV6

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAMTS16_ETV6
Fusion gene ID: 729
HgeneTgene
Gene symbol

ADAMTS16

ETV6

Gene ID

170690

2120

Gene nameADAM metallopeptidase with thrombospondin type 1 motif 16ETS variant 6
SynonymsADAMTS16sTEL|TEL/ABL|THC5
Cytomap

5p15.32

12p13.2

Type of geneprotein-codingprotein-coding
DescriptionA disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16transcription factor ETV6ETS translocation variant 6ETS-related protein Tel1TEL1 oncogeneets variant gene 6 (TEL oncogene)
Modification date2018052220180523
UniProtAcc

Q8TE57

P41212

Ensembl transtripts involved in fusion geneENST00000274181, ENST00000511368, 
ENST00000513709, 
ENST00000396373, 
ENST00000544715, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 9 X 4=324
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/324*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAMTS16 [Title/Abstract] AND ETV6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneETV6

GO:0000122

negative regulation of transcription by RNA polymerase II

10514502


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A7-A4SD-01AADAMTS16chr5

5209359

+ETV6chr12

11905384

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000274181ENST00000396373ADAMTS16chr5

5209359

+ETV6chr12

11905384

+
5CDS-3UTRENST00000274181ENST00000544715ADAMTS16chr5

5209359

+ETV6chr12

11905384

+
In-frameENST00000511368ENST00000396373ADAMTS16chr5

5209359

+ETV6chr12

11905384

+
5CDS-3UTRENST00000511368ENST00000544715ADAMTS16chr5

5209359

+ETV6chr12

11905384

+
intron-3CDSENST00000513709ENST00000396373ADAMTS16chr5

5209359

+ETV6chr12

11905384

+
intron-3UTRENST00000513709ENST00000544715ADAMTS16chr5

5209359

+ETV6chr12

11905384

+

Top

FusionProtFeatures for ADAMTS16_ETV6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAMTS16

Q8TE57

ETV6

P41212

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignanttransformation. {ECO:0000269|PubMed:25581430}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023290_4955351225DomainPeptidase M12B
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023247_2545351225MotifCysteine switch
TgeneETV6chr5:5209359chr12:11905384ENST00000396373+08339_42011453DNA bindingETS
TgeneETV6chr5:5209359chr12:11905384ENST00000396373+0840_12411453DomainPNT

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023642_7465351225Compositional biasNote=Cys-rich
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+10231051_11155351225DomainTSP type-1 5
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+10231127_11815351225DomainTSP type-1 6
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+10231186_12235351225DomainPLAC
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023496_5855351225DomainNote=Disintegrin
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023586_6415351225DomainTSP type-1 1
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023874_9225351225DomainTSP type-1 2
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023927_9875351225DomainTSP type-1 3
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023988_10485351225DomainTSP type-1 4
HgeneADAMTS16chr5:5209359chr12:11905384ENST00000274181+1023747_8735351225RegionNote=Spacer


Top

FusionGeneSequence for ADAMTS16_ETV6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ADAMTS16_ENST00000274181_chr5_5209359_+_ETV6_ENST00000396373_chr12_11905384_+_977aa
MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGETDLVSAYEVDHRGDYVSHEIMHHQRRRRAVP
VSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFTQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL
RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDE
TKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH
TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKTRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC
KKSEGNIMSPTLAGRNGVFSWSPCSRQTLHKFLSTAQAICLADQPKPVKEYKTPEKLPGELTDANTQCKWQFGEKAKLCMLDFKKQERIS
TTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRTRS
PHSGDVLTELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDP
EQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVD
FKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGL

>In-frame_ADAMTS16_ENST00000511368_chr5_5209359_+_ETV6_ENST00000396373_chr12_11905384_+_977aa
MKPRARGWRGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGETDLVSAYEVDHRGDYVSHEIMHHQRRRRAVP
VSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPEDFCFTQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFL
RPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDE
TKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDEQPGLVISHHADH
TLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKTRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMC
KKSEGNIMSPTLAGRNGVFSWSPCSRQTLHKFLSTAQAICLADQPKPVKEYKTPEKLPGELTDANTQCKWQFGEKAKLCMLDFKKQERIS
TTPPESPVPSYASSTPLHVPVPRALRMEEDSIRLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRTRS
PHSGDVLTELLQHILKQRKPRILFSPFFHPGNSIHTQPEVILHQNHEEDNCVQRTPRPSVDNVHHNPPTIELLHRSRSPITTNHRPSPDP
EQRPLRSPLDNMIRRLSPAERAQGPRPHQENNHQESYPLSVSPMENNHCPASSESHPKPSSPRQESTRVIQLMPSPIMHPLILNPRHSVD
FKQSRLSEDGLHREGKPINLSHREDLAYMNHIMVSVSPPEEHAMPIGRIADCRLLWDYVTQLLSDSRYENFIRWEDKESKIFRIVDPNGL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ADAMTS16_ENST00000274181_chr5_5209359_+_ETV6_ENST00000396373_chr12_11905384_+_2931nt
ATGAAGCCCCGCGCGCGCGGATGGCGGGGCTTGGCGGCGCTGTGGATGCTGTTGGCGCAGGTGGCCGAGCAGGCACCTGCGTGCGCCATG
GGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCGTCCCGCGTCCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGAATAT
GACCTGGTCTCTGCCTACGAGGTTGACCACAGGGGCGATTACGTGTCCCATGAAATCATGCACCATCAGCGGCGGAGAAGAGCAGTGCCC
GTGTCCGAGGTTGAGTCTCTTCACCTTCGGCTGAAAGGCTCCAGGCACGACTTCCACATGGATCTGAGGACTTCCAGCAGCCTAGTGGCT
CCTGGCTTTATTGTGCAGACGTTGGGAAAGACAGGCACTAAGTCTGTGCAGACTTTACCGCCAGAGGACTTCTGTTTCTATCAAGGCTCT
TTGCGATCACACAGAAACTCCTCAGTGGCCCTTTCAACCTGCCAAGGCTTGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTA
AGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAG
CCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTG
GGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAG
TATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAA
AAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACA
ATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCAC
ACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGAT
ATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAAT
GAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGC
AAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACAC
AAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAA
TTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGCAGGAACGAATTTCA
TATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGAC
TCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAG
TTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCT
CCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCT
GGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTG
GATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCC
GAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAG
AACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCC
AGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGAT
TTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAAC
CACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATGCCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTAT
CAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTG
GCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATT
ATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCAC

>In-frame_ADAMTS16_ENST00000511368_chr5_5209359_+_ETV6_ENST00000396373_chr12_11905384_+_2931nt
ATGAAGCCCCGCGCGCGCGGATGGCGGGGCTTGGCGGCGCTGTGGATGCTGTTGGCGCAGGTGGCCGAGCAGGCACCTGCGTGCGCCATG
GGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCGTCCCGCGTCCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGAATAT
GACCTGGTCTCTGCCTACGAGGTTGACCACAGGGGCGATTACGTGTCCCATGAAATCATGCACCATCAGCGGCGGAGAAGAGCAGTGCCC
GTGTCCGAGGTTGAGTCTCTTCACCTTCGGCTGAAAGGCTCCAGGCACGACTTCCACATGGATCTGAGGACTTCCAGCAGCCTAGTGGCT
CCTGGCTTTATTGTGCAGACGTTGGGAAAGACAGGCACTAAGTCTGTGCAGACTTTACCGCCAGAGGACTTCTGTTTCTATCAAGGCTCT
TTGCGATCACACAGAAACTCCTCAGTGGCCCTTTCAACCTGCCAAGGCTTGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTA
AGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAG
CCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTG
GGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAG
TATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAA
AAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACA
ATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCAC
ACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGAT
ATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAAT
GAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGC
AAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACAC
AAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAA
TTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGCAGGAACGAATTTCA
TATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCGACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGAC
TCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTACTGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAG
TTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAATGGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCT
CCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATTCTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCT
GGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAGAACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTG
GATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCACCGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCC
GAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGCCGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAG
AACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATGGAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCC
AGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCCAGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGAT
TTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAAGGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAAC
CACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATGCCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTAT
CAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGGGAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTG
GCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACCTATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATT
ATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATGAAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ADAMTS16_ENST00000274181_chr5_5209359_+_ETV6_ENST00000396373_chr12_11905384_+_7425nt
AGTAATAACCCCGGCGCGGCGGCGGAGTCGCTGTGGGGAATCCTCCCGCGCTCTGCCTGGGTCGGGTCCTCCCTGCCCGCTCGCACGCTG
CCGGCCGGGGACCCTCCGGTGGCCCCTAGCCCCTCGGAGCGCTCCTGGATGAAGCCCCGCGCGCGCGGATGGCGGGGCTTGGCGGCGCTG
TGGATGCTGTTGGCGCAGGTGGCCGAGCAGGCACCTGCGTGCGCCATGGGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCGTCCCGCGT
CCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGAATATGACCTGGTCTCTGCCTACGAGGTTGACCACAGGGGCGATTAC
GTGTCCCATGAAATCATGCACCATCAGCGGCGGAGAAGAGCAGTGCCCGTGTCCGAGGTTGAGTCTCTTCACCTTCGGCTGAAAGGCTCC
AGGCACGACTTCCACATGGATCTGAGGACTTCCAGCAGCCTAGTGGCTCCTGGCTTTATTGTGCAGACGTTGGGAAAGACAGGCACTAAG
TCTGTGCAGACTTTACCGCCAGAGGACTTCTGTTTCTATCAAGGCTCTTTGCGATCACACAGAAACTCCTCAGTGGCCCTTTCAACCTGC
CAAGGCTTGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCT
GCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGG
ACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAA
TACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCC
CATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTAC
GTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTT
CTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGG
AAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTT
GCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAG
TCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGA
CGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAG
CCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAG
AAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCG
ACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTAC
TGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAAT
GGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATT
CTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAG
AACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCAC
CGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGC
CGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATG
GAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCC
AGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAA
GGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATG
CCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGG
GAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACC
TATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATG
AAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGAT
GAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAG
GCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGAC
AAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTC
CATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGAC
TCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACA
AAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTC
CTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCT
GTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTT
GGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCAC
CCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTG
AGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGC
AGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTT
CCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACC
TGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGA
TCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCAT
AGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTC
TTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCC
AATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTT
GGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCA
GCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCT
AGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTT
ATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACC
TTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCAT
TCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATT
GTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATG
TTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATT
ATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGC
CACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTA
AAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTC
TTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATAT
GAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATAT
ATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCT
GGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGT
TCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACC
TTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCC
ACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTG
CCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGA
AAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGG
CATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCA
GTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGT
GACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCC
CTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGA
TCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGT
TTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGA
AGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACA
CTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACC
AGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAA
TCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGC

>In-frame_ADAMTS16_ENST00000511368_chr5_5209359_+_ETV6_ENST00000396373_chr12_11905384_+_7425nt
AGTAATAACCCCGGCGCGGCGGCGGAGTCGCTGTGGGGAATCCTCCCGCGCTCTGCCTGGGTCGGGTCCTCCCTGCCCGCTCGCACGCTG
CCGGCCGGGGACCCTCCGGTGGCCCCTAGCCCCTCGGAGCGCTCCTGGATGAAGCCCCGCGCGCGCGGATGGCGGGGCTTGGCGGCGCTG
TGGATGCTGTTGGCGCAGGTGGCCGAGCAGGCACCTGCGTGCGCCATGGGACCCGCAGCGGCAGCGCCTGGGAGCCCGAGCGTCCCGCGT
CCTCCTCCACCCGCGGAGCGGCCGGGCTGGATGGAAAAGGGCGAATATGACCTGGTCTCTGCCTACGAGGTTGACCACAGGGGCGATTAC
GTGTCCCATGAAATCATGCACCATCAGCGGCGGAGAAGAGCAGTGCCCGTGTCCGAGGTTGAGTCTCTTCACCTTCGGCTGAAAGGCTCC
AGGCACGACTTCCACATGGATCTGAGGACTTCCAGCAGCCTAGTGGCTCCTGGCTTTATTGTGCAGACGTTGGGAAAGACAGGCACTAAG
TCTGTGCAGACTTTACCGCCAGAGGACTTCTGTTTCTATCAAGGCTCTTTGCGATCACACAGAAACTCCTCAGTGGCCCTTTCAACCTGC
CAAGGCTTGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCT
GCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGG
ACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAA
TACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCC
CATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTAC
GTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTT
CTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGG
AAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTT
GCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAG
TCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGA
CGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAG
CCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAG
AAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGCAGGAACGAATTTCATATACACCTCCAGAGAGCCCAGTGCCGAGTTACGCTTCCTCG
ACGCCACTTCATGTTCCAGTGCCTCGAGCGCTCAGGATGGAGGAAGACTCGATCCGCCTGCCTGCGCACCTGCGCTTGCAGCCAATTTAC
TGGAGCAGGGATGACGTAGCCCAGTGGCTCAAGTGGGCTGAAAATGAGTTTTCTTTAAGGCCAATTGACAGCAACACGTTTGAAATGAAT
GGCAAAGCTCTCCTGCTGCTGACCAAAGAGGACTTTCGCTATCGATCTCCTCATTCAGGTGATGTGCTCTATGAACTCCTTCAGCATATT
CTGAAGCAGAGGAAACCTCGGATTCTTTTTTCACCATTCTTCCACCCTGGAAACTCTATACACACACAGCCGGAGGTCATACTGCATCAG
AACCATGAAGAAGATAACTGTGTCCAGAGGACCCCCAGGCCATCCGTGGATAATGTGCACCATAACCCTCCCACCATTGAACTGTTGCAC
CGCTCCAGGTCACCTATCACGACAAATCACCGGCCTTCTCCTGACCCCGAGCAGCGGCCCCTCCGGTCCCCCCTGGACAACATGATCCGC
CGCCTCTCCCCGGCTGAGAGAGCTCAGGGACCCAGGCCGCACCAGGAGAACAACCACCAGGAGTCCTACCCTCTGTCAGTGTCTCCCATG
GAGAATAATCACTGCCCAGCGTCCTCCGAGTCCCACCCGAAGCCATCCAGCCCCCGGCAGGAGAGCACACGCGTGATCCAGCTGATGCCC
AGCCCCATCATGCACCCTCTGATCCTGAACCCCCGGCACTCCGTGGATTTCAAACAGTCCAGGCTCTCCGAGGACGGGCTGCATAGGGAA
GGGAAGCCCATCAACCTCTCTCATCGGGAAGACCTGGCTTACATGAACCACATCATGGTCTCTGTCTCCCCGCCTGAAGAGCACGCCATG
CCCATTGGGAGAATAGCAGACTGTAGACTGCTTTGGGATTACGTCTATCAGTTGCTTTCTGACAGCCGGTACGAAAACTTCATCCGATGG
GAGGACAAAGAATCCAAAATATTCCGGATAGTGGATCCCAACGGACTGGCTCGACTGTGGGGAAACCATAAGAACAGAACAAACATGACC
TATGAGAAAATGTCCAGAGCCCTGCGCCACTACTACAAACTAAACATTATCAGGAAGGAGCCAGGACAAAGGCTTTTGTTCAGGTTTATG
AAAACCCCAGATGAAATCATGAGTGGCCGAACAGACCGTCTGGAGCACCTAGAGTCCCAGGAGCTGGATGAACAAATATACCAAGAAGAT
GAATGCTGAAGGAACCAACAGTCCACCTCAGCGGGCCAGCAGCCCAGGGAACCCCTGCCCACCAGGATTGCTGGAAGTGTGACGGAGCAG
GCGGGCTGAGGAGAGTGGAAAAGGAAGCGACCCAGAAATGGCAGGGACACTTCTCTTGCAGACCAAGAGGGACCCTGGAGCACCTTAGAC
AAACTACCCAGCACAGGCGGGGCTGGAATTCTGGCGGAGGGCATGAGCCTGGGACTCCATGTCACGTTTCCTTCTGATTTGGAATCTCTC
CATCTGTAATTCCTCACCCTCACCCTTCCACCGTTGTTAGTATCATGGTGTTTTTGTTTTTGTTTTTGTTTTAAGAACCTGCAGTTTGAC
TCTTCATCGTTCATCTAGGGGAAGACATCTGATGTTGTTTTCCTATGGAAATATATATCTATTATATATATATTTTTTGCAAATCTCACA
AAGTGCGGCAAGCCCAGCTGGTCAGGAAAGAGAATACTTGCAGAGGGGTTCAGGTTCCTCTTTTTCCTGCCACGTGGATCAGGTCTGTTC
CTGTTACTGTTGGGTCTTGGCTGAAAAAAAAAAATGCTTTTAAAAAAGATAAAATGAAAAGGAGAGCTCTCTTTTTCTCTCTCTTGCTCT
GTTCTTCCCTTGGTCCCCTCTGTCCTCCCGCCCTGCCTGCAGTTGAGATTCAGATGCCTTCTGACAGAGTTCAGCCTCTTGGAGAGTCTT
GGGGATTGTTGGCACCTAAACAGAATCAGTGACCCGGGTGCTTTGTGGCCAGCAGCACAGAATCAAACCCGCATCCCAGCATTGGGCCAC
CCATCTGAGGGAGGCCAAAATCATCACAGATGCTGCTGTGCTGCAGACAGATACATGCTAGTCCAGAGAGCCGCCCCTGAGATGGCTGTG
AGAACCATGTGTCTAAGGCGTAAGATAAGGATGGAAGGCTGTCCAAGTTATTTGGAAGGCCTCGGCAGCTTGGGATTAGCTTGGGAGCGC
AGCGCTGCAAAGTGGAAAATATGAAAAGACCACACAGGCCCAGCAGTCCAGAAACTGGGCAAAAATATTCTGCAGTGGGGATTTATTTTT
CCAAAGCAGGTAACAGAGGCTAGTGAGAAAGAAAAGCTCCTCTCTGCTCCATTCCAAAGGCCATCTTGTGGTCAGTTTCATGCCCTCACC
TGATTTTTTTTTTTTTTTTTTTTTTTCAATTCCTAACCTTTTTTAAAGTTTCCTGGTCTCCACTGGACACAGAGCTTTGGAGACGGAGGA
TCCCAGAGGGCAGTCTCAGTTGCAATCAGTGTGTGCCCAGCCTGGGCAGACAGGAAATTCCTCGGATACATTATTTTTTCTTTCTTTCAT
AGCTGTGTCTCAGAAAGGACCCATTTGTGGCTCTTTTTCACCTCAAAATAAGATCGATGGTATCTTGTAAAATGAGGGTAGTGCCACTTC
TTAGTATTTTTGAAAGCTGTTTTAGATTTTTTTTTTTTTTCCTTTTCTAGCCATCTAAATTGACTCTTCCAATATAGGTCTCAGAAATCC
AATATTTGGAGTACAATTTCTTTTAATCCAGATTACACCTGCCTTACAAAGCACCCCCTCCTTGTTCCCCTCTGTTTCCTCTACTCAGTT
GGGGGAGAAACTCACAGCTCCTCCGGGATACATATGTGCCCTCAGCAGCAGCTCCCAGGTGAAGTTACCAGACCCCTGGGCTTCTCCCCA
GCTTTTTCTGAGTTGAGTCAGACATGTAGAGTTTGGGTCACACAGGCAAGAGGAATTTTCCCTCGGCCTTACTGACAAGGACACCAACCT
AGGGTGCAAACAGATGGACTATGGTTCAAGGACACTGGAATTGAGGAGCTGATCAAGGCTCTCTTCAGCCTTGCTCTGTCCCTGCCTCTT
ATCAGAGCACAGGTAGACACACGGGCATAGCCAGCCCACTCCTACTGTCACAGGCGCCCCACCATTCAACCTTCCGGGAGGTCAGGGACC
TTCTATATGAGGCGAGTGGGTCTCAGTCTGCTTGAATGGTGATGAGATTCTGCTGGATCTCAGCACGCTGCAGGTGTCTTTTGAGAGCAT
TCAGTAGGACATGGTGATCCCTATTTCAGCCTCTAAGATGACTGGTATTCTATCTGAAATGCAGAGATTAAGCCAAATACCTGATGTATT
GTGAAAGCCACTGATTTTAAGAATGGAGAGAAAGGGATTTTTTACTGCATCCCTCTGTATGAATATGAAATCAGAGACCAGGGCATGATG
TTGCTAGGATTAGAGCCTCTCAGTCTGGCCTCTTCACCCAAGTGCAAGAACTCAGTCTCTTACTGTTCAAAGAATCTTAACAGTTGAATT
ATGGAGGGAAATTCCCTTTTGCCCCAAGCATTTCTATATTTAAAGCAATATCCCAGGAGAATATGTTAGACTTAGGATGATACCTTCAGC
CACTTGAAGAAGAAATAGAAGGCGCTCATTCCAATATAGTCTTTATTTCCCATTCAGATACAGGTTGAGCATCCCTAATCTGAACAGTTA
AAACCCCCAAATGCCCCAAAATCCAAACCTTCCTGAACGCTATGACACCATGAGTGGAAAATTCCACACCTAACAAACACATTTGCTTTC
TTATGGTTCAATGTACACAAACTGTTTTATATAGAAAATGATTTCAAATATCATAAAATTACCTTCAGGCTATGTGTATAAAGTATATAT
GAGCCATAAATGAATTTTGTGTTTAGACTTTGTGTCCATCCCCAAGATCTCTCATTTTATATATATATATATATATATATATATATATAT
ATATATATATATATACACACACACACACATACACAAATATTCCAGGATACAAAAAAAAACATTTAAAAATCCGAGACCCAGAACACTTCT
GGTCCCAAGCATTTCAGATAAGGGATATCAATCTGTACTACCAATAAGGATTTCGTAATTCCCCTAACTGCAAATGTCCTCTTCATTTGT
TCTTTATGAGAAAACCCGGGTAGTGCCAGCACCTGGATACAGTATTTACACCCTGCAGACCCTAAAGATTTCAGATTCAGTTAGCAAACC
TTGATGAAGCACCTGCTGGACACTGAGGGACCCAAAGCTCAATCAGCCATAATCCCTGCTTTCAGAGTTTATATTGTACCTGCCTAATCC
ACCCGGCGTGACTCATTTCAACACTAAGTACTAGGGGTGTTGTCAGGAGACAAATCTGAAGTCAGGAGAGGAAAATGCAAAGGAGCCCTG
CCGTGTGATGGATGTGCATTCTCACTTGGGTCTTGAAGTTCTCATTCCTACATCTCAAGCTAGCCAGGCAGTCTCCTCTCTATCAGAAGA
AAGCACTGGTAATTGGCTAGACTGGCTATGTTGAAGGTAACATGAACTCTAAGATCTTGACCCAGGGCGACTTGGTTTTGCTTAAGGTGG
CATCACCAATGTTCCAAATCCTTTAGGGAGATGAGGGTATCCCCACAGAAAAAGAGGAATAATAGACCAATGGATTTTCTCCTTTCACCA
GTATGTTTGGAACCCTCTGATCCAATGTCTTTTGATACTGATCTCTTGTCCAAATGAGAATGTCGCTTTAGCTGAAATTCAAATGGCTGT
GACAATTTACCGAAATGATGAAGTAACCACCATTCCCACCTTTCACTGCCTAGGCTCCAAGTCTGAATACATTTTTGAAATAGGAACTCC
CTTTTGCAAAAAAGAAACCTGGGTGTCAGGGAGGTGAAGTGACTTGCCCTAGGAGCAGACAGCATGCCAAGAATGGAATTAGGCTCAGGA
TCCAGCCTGGGCTCACCCTGTGTGGCTCATTCCCACCCAGGAAACTGAAGATAAAAGATTTGGGAAAACACACCAAGAAAAAGGGGCAGT
TTTCTTTGCCCAAGCATTTGGTGCTAGTTAGAGGCTGTTCACTCTCTCCTGCTCCTCTTCGGAGTAGAAATAAAGGCTGTGACACAAGGA
AGCCAGTGGGGTGGGAGGGAGGCACCATAATCCCTCCCTAAAACCCACAGAAGACTAACCTGATACTCTTTTGACCCAACTGCATCAACA
CTAAACAGCTGCAGACCCCCTGAATCTTTCACACATGCCAAGTGAACATTCTTGATGATTTCTCTTTGTGACCGCAACCACCTGCAAACC
AGAACGACTCTAGAATTTCCTTCCCCGCCCCCCTTTTTGTTTAGTTTCTAATCTCTTGTTTATGAGGTGTGGGGTTTATAAGGGACTGAA
TCAAATGAATGTAACAAAAAAGAAAAAAAAAACAAAAAAAAATGCCTTTTCTCAGGGCCAGTGAGTTGCAAATAATTTTTAAAGAAAAGC


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FusionGenePPI for ADAMTS16_ETV6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAMTS16ETV6KAT5, GAB2, ETV6, GRB2, CRKL, ACTA1, HDAC9, FLI1, FBXL6, SKP1, L3MBTL1, IRF8, NCOR1, SIN3A, HDAC3, UBE2I, ELAVL1, PDGFRB, SUMO1, SOCS1, SOCS3, TRAF3, SOX2, HDAC6, PIN1, AP1M1, WDYHV1, LRP6, LRP5, NID2, ETV7, USP7, VPS26B, NFATC2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAMTS16_ETV6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAMTS16_ETV6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneETV6C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3CTD_human
TgeneETV6C0040034Thrombocytopenia2CTD_human;HPO
TgeneETV6C0236969Substance-Related Disorders1CTD_human
TgeneETV6C0376545Hematologic Neoplasms1CTD_human
TgeneETV6C1838656Macrocytosis, Familial1CTD_human
TgeneETV6C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneETV6C3495559Juvenile arthritis1CTD_human
TgeneETV6C4015537THROMBOCYTOPENIA 51UNIPROT