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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7285

FusionGeneSummary for CKB_LSM14B

check button Fusion gene summary
Fusion gene informationFusion gene name: CKB_LSM14B
Fusion gene ID: 7285
HgeneTgene
Gene symbol

CKB

LSM14B

Gene ID

1152

149986

Gene namecreatine kinase BLSM family member 14B
SynonymsB-CK|BCK|CKBB|CPK-B|HEL-211|HEL-S-29C20orf40|FAM61B|FT005|LSM13|RAP55B|bA11M20.3
Cytomap

14q32.33

20q13.33

Type of geneprotein-codingprotein-coding
Descriptioncreatine kinase B-typebrain creatine kinasecreatine kinase B chaincreatine kinase braincreatine kinase brain-typecreatine phosphokinase B-typeepididymis luminal protein 211epididymis secretory protein Li 29protein LSM14 homolog BLSM14 homolog BLSM14B, SCD6 homolog BRNA-associated protein 55Bfamily with sequence similarity 61, member BhRAP55B
Modification date2018051920180519
UniProtAcc

P12277

Q9BX40

Ensembl transtripts involved in fusion geneENST00000348956, ENST00000370915, 
ENST00000253001, ENST00000279068, 
Fusion gene scores* DoF score6 X 7 X 4=1683 X 3 X 2=18
# samples 103
** MAII scorelog2(10/168*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CKB [Title/Abstract] AND LSM14B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW847911CKBchr14

103988480

+LSM14Bchr20

60701377

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000348956ENST00000370915CKBchr14

103988480

+LSM14Bchr20

60701377

+
intron-3CDSENST00000348956ENST00000253001CKBchr14

103988480

+LSM14Bchr20

60701377

+
intron-3CDSENST00000348956ENST00000279068CKBchr14

103988480

+LSM14Bchr20

60701377

+

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FusionProtFeatures for CKB_LSM14B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CKB

P12277

LSM14B

Q9BX40

Reversibly catalyzes the transfer of phosphate betweenATP and various phosphogens (e.g. creatine phosphate). Creatinekinase isoenzymes play a central role in energy transduction intissues with large, fluctuating energy demands, such as skeletalmuscle, heart, brain and spermatozoa. May play a role in control of mRNA translation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CKB_LSM14B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CKB_LSM14B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CKB_LSM14B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CKB_LSM14B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCKBC0001418Adenocarcinoma1CTD_human
HgeneCKBC0027051Myocardial Infarction1CTD_human
HgeneCKBC0036341Schizophrenia1PSYGENET
HgeneCKBC0038356Stomach Neoplasms1CTD_human
HgeneCKBC0149721Left Ventricular Hypertrophy1CTD_human
HgeneCKBC0149925Small cell carcinoma of lung1CTD_human
HgeneCKBC0857501acute schizophrenia1PSYGENET
HgeneCKBC0948089Acute Coronary Syndrome1CTD_human