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Fusion gene ID: 7265 |
FusionGeneSummary for CIT_NUTF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CIT_NUTF2 | Fusion gene ID: 7265 | Hgene | Tgene | Gene symbol | CIT | NUTF2 | Gene ID | 79947 | 10204 |
| Gene name | dehydrodolichyl diphosphate synthase subunit | nuclear transport factor 2 | |
| Synonyms | CIT|CPT|DEDSM|DS|HDS|RP59 | NTF-2|NTF2|PP15 | |
| Cytomap | 1p36.11 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dehydrodolichyl diphosphate synthase complex subunit DHDDScis-IPTasecis-isoprenyltransferasecis-prenyl transferasededol-PP synthasedehydrodolichyl diphosphate syntase complex subunit DHDDSepididymis tissue protein Li 189m | nuclear transport factor 2placental protein 15 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14578 | P61970 | |
| Ensembl transtripts involved in fusion gene | ENST00000392521, ENST00000261833, ENST00000537607, | ENST00000219169, ENST00000569436, ENST00000568396, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 7 X 4 X 5=140 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CIT [Title/Abstract] AND NUTF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NUTF2 | GO:0006606 | protein import into nucleus | 7744965|10679025 |
| Tgene | NUTF2 | GO:0006611 | protein export from nucleus | 16449645 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI590610 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000392521 | ENST00000219169 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000392521 | ENST00000569436 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000392521 | ENST00000568396 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000261833 | ENST00000219169 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000261833 | ENST00000569436 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000261833 | ENST00000568396 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000537607 | ENST00000219169 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000537607 | ENST00000569436 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
| intron-intron | ENST00000537607 | ENST00000568396 | CIT | chr12 | 120220235 | + | NUTF2 | chr16 | 67891149 | - |
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FusionProtFeatures for CIT_NUTF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CIT | NUTF2 |
| Plays a role in cytokinesis. Required for KIF14localization to the central spindle and midbody. Putative RHO/RACeffector that binds to the GTP-bound forms of RHO and RAC1. Itprobably binds p21 with a tighter specificity in vivo. Displaysserine/threonine protein kinase activity. Plays an important rolein the regulation of cytokinesis and the development of thecentral nervous system. Phosphorylates MYL9/MLC2.{ECO:0000269|PubMed:16236794, ECO:0000269|PubMed:16431929,ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:27453578}. | Mediates the import of GDP-bound RAN from the cytoplasminto the nucleus which is essential for the function of RAN incargo receptor-mediated nucleocytoplasmic transport. Thereby,plays indirectly a more general role in cargo receptor-mediatednucleocytoplasmic transport. Interacts with GDP-bound RAN in thecytosol, recruits it to the nuclear pore complex via itsinteraction with nucleoporins and promotes its nuclear import.{ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:7744965}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CIT_NUTF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CIT_NUTF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CIT_NUTF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CIT_NUTF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NUTF2 | C0019693 | HIV Infections | 1 | CTD_human |
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