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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7247

FusionGeneSummary for CIR1_SCRN3

check button Fusion gene summary
Fusion gene informationFusion gene name: CIR1_SCRN3
Fusion gene ID: 7247
HgeneTgene
Gene symbol

CIR1

SCRN3

Gene ID

9541

79634

Gene namecorepressor interacting with RBPJ, 1secernin 3
SynonymsCIRSES3
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptioncorepressor interacting with RBPJ 1CBF1-interacting corepressorrecepinsecernin-3
Modification date2018052720180523
UniProtAcc

Q86X95

Q0VDG4

Ensembl transtripts involved in fusion geneENST00000342016, ENST00000362053, 
ENST00000409673, ENST00000272732, 
ENST00000548921, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 3 X 4=48
# samples 44
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CIR1 [Title/Abstract] AND SCRN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCIR1

GO:0045892

negative regulation of transcription, DNA-templated

9874765


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-ZG-A9LZ-01ACIR1chr2

175260279

-SCRN3chr2

175264650

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000342016ENST00000409673CIR1chr2

175260279

-SCRN3chr2

175264650

+
In-frameENST00000342016ENST00000272732CIR1chr2

175260279

-SCRN3chr2

175264650

+
5CDS-intronENST00000342016ENST00000548921CIR1chr2

175260279

-SCRN3chr2

175264650

+
In-frameENST00000362053ENST00000409673CIR1chr2

175260279

-SCRN3chr2

175264650

+
In-frameENST00000362053ENST00000272732CIR1chr2

175260279

-SCRN3chr2

175264650

+
5CDS-intronENST00000362053ENST00000548921CIR1chr2

175260279

-SCRN3chr2

175264650

+

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FusionProtFeatures for CIR1_SCRN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CIR1

Q86X95

SCRN3

Q0VDG4

May modulate splice site selection during alternativesplicing of pre-mRNAs (By similarity). Regulates transcription andacts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histonedeacetylase complex (HDAC). Required for RBPJ-mediated repressionof transcription. {ECO:0000250, ECO:0000269|PubMed:19409814,ECO:0000269|PubMed:9874765}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCIR1chr2:175260279chr2:175264650ENST00000342016-110214_36824451Compositional biasNote=Lys/Ser-rich
HgeneCIR1chr2:175260279chr2:175264650ENST00000342016-110369_45024451Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneCIR1chr2:175260279chr2:175264650ENST00000362053-111214_36824496Compositional biasNote=Lys/Ser-rich
HgeneCIR1chr2:175260279chr2:175264650ENST00000362053-111369_45024496Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneCIR1chr2:175260279chr2:175264650ENST00000342016-110235_24524451MotifNuclear localization signal
HgeneCIR1chr2:175260279chr2:175264650ENST00000342016-110291_29824451MotifNuclear localization signal
HgeneCIR1chr2:175260279chr2:175264650ENST00000362053-111235_24524496MotifNuclear localization signal
HgeneCIR1chr2:175260279chr2:175264650ENST00000362053-111291_29824496MotifNuclear localization signal


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FusionGeneSequence for CIR1_SCRN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CIR1_SCRN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CIR1SNW1, RBPJ, SAP30, NCOR2, RP9, SRSF2, SRSF1, U2AF1, NEK6, CEP76, FANCI, AGO3, CCNYL1, UBR3, GCA, BTBD1, DCAF10, CDCA3, RBM12, CTNNA2, EPHA2SCRN3EPS8, MAGOH, SMYD1, RCVRN, SPATA20


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCIR1chr2:175260279chr2:175264650ENST00000342016-1101_12124451RBPJ
HgeneCIR1chr2:175260279chr2:175264650ENST00000362053-1111_12124496RBPJ
HgeneCIR1chr2:175260279chr2:175264650ENST00000342016-110204_23224451RP9
HgeneCIR1chr2:175260279chr2:175264650ENST00000362053-111204_23224496RP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CIR1_SCRN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CIR1_SCRN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource