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Fusion gene ID: 722 |
FusionGeneSummary for ADAMTS10_MLLT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADAMTS10_MLLT1 | Fusion gene ID: 722 | Hgene | Tgene | Gene symbol | ADAMTS10 | MLLT1 | Gene ID | 81794 | 4298 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 10 | MLLT1, super elongation complex subunit | |
| Synonyms | ADAM-TS10|ADAMTS-10|WMS|WMS1 | ENL|LTG19|YEATS1 | |
| Cytomap | 19p13.2 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | A disintegrin and metalloproteinase with thrombospondin motifs 10ADAM-TS 10a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10zinc metalloendopeptidase | protein ENLCTC-503J8.6ENL/MLL fusionMLL/ENL fusion proteinMLLT1/MLL fusionYEATS domain-containing protein 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homol | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9H324 | Q03111 | |
| Ensembl transtripts involved in fusion gene | ENST00000595838, ENST00000270328, ENST00000597188, ENST00000596709, | ENST00000252674, ENST00000585588, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 20 X 6=1200 |
| # samples | 1 | 25 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(25/1200*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADAMTS10 [Title/Abstract] AND MLLT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AC-A2B8-01A | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000595838 | ENST00000252674 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| intron-intron | ENST00000595838 | ENST00000585588 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| Frame-shift | ENST00000270328 | ENST00000252674 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| 5CDS-intron | ENST00000270328 | ENST00000585588 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| In-frame | ENST00000597188 | ENST00000252674 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| 5CDS-intron | ENST00000597188 | ENST00000585588 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| 5UTR-3CDS | ENST00000596709 | ENST00000252674 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
| 5UTR-intron | ENST00000596709 | ENST00000585588 | ADAMTS10 | chr19 | 8665812 | - | MLLT1 | chr19 | 6270770 | - |
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FusionProtFeatures for ADAMTS10_MLLT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADAMTS10 | MLLT1 |
| Metalloprotease that participate in microfibrilsassembly. Microfibrils are extracellular matrix componentsoccurring independently or along with elastin in the formation ofelastic tissues. {ECO:0000269|PubMed:21402694}. | Component of the super elongation complex (SEC), acomplex required to increase the catalytic rate of RNA polymeraseII transcription by suppressing transient pausing by thepolymerase at multiple sites along the DNA.{ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAMTS10_MLLT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADAMTS10_ENST00000597188_chr19_8665812_-_MLLT1_ENST00000252674_chr19_6270770_-_826aa MAPACQILRWALALGLGLMFEVTHAFRSQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLN LTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVY KRSSLRHPHLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNI CTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEE PRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDA NKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPP PPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDE ASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPS REPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADAMTS10_ENST00000597188_chr19_8665812_-_MLLT1_ENST00000252674_chr19_6270770_-_2478nt ATGGCTCCCGCCTGCCAGATCCTCCGCTGGGCCCTCGCCCTGGGGCTGGGCCTCATGTTCGAGGTCACGCACGCCTTCCGGTCTCAAGAT GAGTTCCTGTCCAGTCTGGAGAGCTATGAGATCGCCTTCCCCACCCGCGTGGACCACAACGGGGCACTGCTGGCCTTCTCGCCACCTCCT CCCCGGAGGCAGCGCCGCGGCACGGGGGCCACAGCCGAGTCCCGCCTCTTCTACAAAGTGGCCTCGCCCAGCACCCACTTCCTGCTGAAC CTGACCCGCAGCTCCCGTCTACTGGCAGGGCACGTCTCCGTGGAGTACTGGACACGGGAGGGCCTGGCCTGGCAGAGGGCGGCCCGGCCC CACTGCCTCTACGCTGGTCACCTGCAGGGCCAGGCCAGCACCTCCCATGTGGCCATCAGCACCTGTGGAGGCCTGCACGGCCTGATCGTG GCAGACGAGGAAGAGTACCTGATTGAGCCCCTGCACGGTGGGCCCAAGGGTTCTCGGAGCCCGGAGGAAAGTGGACCACATGTGGTGTAC AAGCGTTCCTCTCTGCGTCACCCCCACCTGGACACAGCCTGTGGAGTGAGAGATGAGAAACCGTGGAAAGGGCGGCCATGGTGGCTGCGG ACCTTGAAGCCACCGCCTGCCAGGCCCCTGGGGAATGAAACAGAGCGTGGCCAGCCAGGCCTGAAGCGATCGGTCAGCCGAGAGCGCTAC GTGGAGACCCTGGTGGTGGCTGACAAGATGATGGTGGCCTATCACGGGCGCCGGGATGTGGAGCAGTATGTCCTGGCCATCATGAACATT TGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGTG TTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACGC GTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGAG CCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTTC AACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCCC AGTCCCGACTACCCCATGTTACCCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGCC AACAAGGAGAGCAGCAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTCC TCCAAGGAGCTGGAGCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGCG CCACCGCCCAAGGCTGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACCC CCACCCCCACCCCCACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAGC TCGAAGGGGTCCCGGAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAGC AGCACCAGAGGGGAGAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGAG GCCTCCTTCAAGTCCGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATCC CAGAACCACAGCCAAGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGAG GCTGCCGGCAAGACCAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAGC CGTGAGCCCCCACCCCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAAG ATCCTCAAGAAGGGCACCTACGACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGTG CTGCAGCAGATTGTGAATCTGATCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADAMTS10_ENST00000597188_chr19_8665812_-_MLLT1_ENST00000252674_chr19_6270770_-_2836nt CGCGCGGGGCGGCGAGACAGCGGCGGCGACGGCGCGGAGGCCCCGGGCGCGGCGCAGGCTCCAAAGAAGAAGAAACCAAGGCCCAGAGAG GGAGGCCCAGGTGCAGGGAGCAGGCGAGGGAAGGATCCGTACAGGGGCCCAACACTACTCCACCAACCGAAGCCCCCAAAAGGAGCCCGG TGATGCTGCGAAGGCTGTGAACAGGGGAGGCGGCACTGTGGGGGCTGCCGGCAGCCGGGGCTGGGGAGAGACATGTGGACACGTGGCCTC TATGGCTCCCGCCTGCCAGATCCTCCGCTGGGCCCTCGCCCTGGGGCTGGGCCTCATGTTCGAGGTCACGCACGCCTTCCGGTCTCAAGA TGAGTTCCTGTCCAGTCTGGAGAGCTATGAGATCGCCTTCCCCACCCGCGTGGACCACAACGGGGCACTGCTGGCCTTCTCGCCACCTCC TCCCCGGAGGCAGCGCCGCGGCACGGGGGCCACAGCCGAGTCCCGCCTCTTCTACAAAGTGGCCTCGCCCAGCACCCACTTCCTGCTGAA CCTGACCCGCAGCTCCCGTCTACTGGCAGGGCACGTCTCCGTGGAGTACTGGACACGGGAGGGCCTGGCCTGGCAGAGGGCGGCCCGGCC CCACTGCCTCTACGCTGGTCACCTGCAGGGCCAGGCCAGCACCTCCCATGTGGCCATCAGCACCTGTGGAGGCCTGCACGGCCTGATCGT GGCAGACGAGGAAGAGTACCTGATTGAGCCCCTGCACGGTGGGCCCAAGGGTTCTCGGAGCCCGGAGGAAAGTGGACCACATGTGGTGTA CAAGCGTTCCTCTCTGCGTCACCCCCACCTGGACACAGCCTGTGGAGTGAGAGATGAGAAACCGTGGAAAGGGCGGCCATGGTGGCTGCG GACCTTGAAGCCACCGCCTGCCAGGCCCCTGGGGAATGAAACAGAGCGTGGCCAGCCAGGCCTGAAGCGATCGGTCAGCCGAGAGCGCTA CGTGGAGACCCTGGTGGTGGCTGACAAGATGATGGTGGCCTATCACGGGCGCCGGGATGTGGAGCAGTATGTCCTGGCCATCATGAACAT TTGCACCGTCCAGGTGAGGTTAGAGCTGGGGCATCGCGCCCAACTGCGCAAGAAGCCCACCACGGAGGGGTTCACTCACGACTGGATGGT GTTTGTCCGCGGCCCCGAGCAATGTGACATCCAGCACTTCGTGGAGAAGGTGGTCTTCTGGCTGCACGACAGCTTCCCCAAGCCCAGACG CGTGTGCAAGGAGCCCCCCTACAAAGTAGAGGAGTCGGGGTACGCTGGCTTCATCATGCCCATCGAGGTGCACTTCAAAAACAAGGAGGA GCCGAGGAAGGTCTGCTTCACCTACGACCTGTTCCTGAACCTGGAAGGCAACCCGCCCGTGAACCACCTGCGCTGCGAGAAGCTCACCTT CAACAACCCCACCACGGAGTTCCGGTACAAGCTCCTGCGGGCCGGCGGGGTGATGGTAATGCCCGAAGGAGCAGACACGGTGTCCAGGCC CAGTCCCGACTACCCCATGTTACCCACAATTCCACTCTCTGCCTTCTCTGACCCCAAGAAGACCAAACCATCCCACGGCTCCAAGGACGC CAACAAGGAGAGCAGCAAGACCTCCAAGCCACACAAGGTGACCAAGGAGCACCGGGAGCGGCCCCGCAAAGACTCCGAGAGCAAGAGCTC CTCCAAGGAGCTGGAGCGTGAGCAGGCCAAAAGCTCCAAGGACACCTCGCGGAAGCTGGGCGAGGGCCGGCTGCCCAAGGAGGAGAAGGC GCCACCGCCCAAGGCTGCCTTCAAGGAACCCAAGATGGCCCTGAAAGAGACCAAGCTGGAAAGCACGTCCCCCAAGGGTGGGCCCCCACC CCCACCCCCACCCCCACCCCGGGCTTCCAGCAAGCGGCCGGCCACCGCCGACTCGCCAAAGCCCAGCGCCAAGAAGCAGAAGAAGAGCAG CTCGAAGGGGTCCCGGAGTGCTCCAGGCACCTCGCCCCGCACCTCCTCCTCCTCCTCCTTCTCGGACAAGAAGCCGGCCAAGGACAAGAG CAGCACCAGAGGGGAGAAGGTGAAGGCCGAGAGTGAGCCCCGGGAGGCCAAAAAGGCCCTGGAGGTGGAGGAGTCCAACTCAGAGGACGA GGCCTCCTTCAAGTCCGAGTCTGCCCAGTCAAGCCCGTCCAACTCCAGCTCCAGCTCAGACTCCAGCTCAGACTCAGACTTCGAGCCATC CCAGAACCACAGCCAAGGACCCCTGCGCTCCATGGTGGAGGACCTGCAGTCCGAGGAGTCCGACGAGGACGACTCTTCGTCAGGCGAGGA GGCTGCCGGCAAGACCAACCCGGGGAGGGACTCCAGGTTGAGCTTCAGCGACAGCGAGAGTGACAACAGCGCCGACTCCTCCCTGCCCAG CCGTGAGCCCCCACCCCCCCAGAAGCCACCCCCGCCCAACAGCAAGGTGTCAGGCCGGAGGAGCCCCGAGTCCTGCAGCAAGCCTGAGAA GATCCTCAAGAAGGGCACCTACGACAAGGCCTACACGGATGAGCTGGTGGAGCTACACCGGAGGCTGATGGCGCTGCGGGAGCGCAACGT GCTGCAGCAGATTGTGAATCTGATCGAGGAGACTGGCCACTTCAATGTCACCAACACCACCTTCGACTTCGACCTCTTCTCCCTGGACGA GACCACCGTGCGCAAACTGCAGAGCTGCCTGGAGGCCGTGGCCACATGACCCTGGGCCGCGTGCCGGGCCCCCACCGCCGGGGTCCTGGG |
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FusionGenePPI for ADAMTS10_MLLT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADAMTS10 | PCYT2, TK1, CDKN1A, LAMTOR3, SMN1, ANXA7, HMGCL | MLLT1 | CBX8, AFF1, CDK9, WDR5, DOT1L, MLLT3, RFX5, AFF4, CSNK2A1, BCOR, RFXAP, MLLT10, ACACA, CHD1, ELL, SIRT1, MLLT6, CCNT1, KMT2A, BRD4, ELL2, PAF1, POLR2A, MED26, HIST3H3, HIST1H1B, EAF1, ELL3, RNF2, RPL12, MRPL12, HIST2H2AC, H2AFX, HIST2H2BE, HIST4H4, BMI1, PIP4K2A, EPB41L2, CAMKV, BPIFB1, YAF2, RYBP, DENND2D, ARRB2, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAMTS10_MLLT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAMTS10_MLLT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADAMTS10 | C1869114 | Weill-Marchesani Syndrome, Autosomal Recessive | 1 | UNIPROT |
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