	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 7210

FusionGeneSummary for CHTOP_CHTOP

Fusion gene summary

Fusion gene information	Fusion gene name: CHTOP_CHTOP
	Fusion gene ID: 7210
		Hgene	Tgene
	Gene symbol	CHTOP	CHTOP
	Gene ID	26097	26097
	Gene name	chromatin target of PRMT1	chromatin target of PRMT1
	Synonyms	C10orf77\|C1orf77\|FL-SRAG\|FOP\|SRAG\|SRAG-3\|SRAG-5\|pp7704	C10orf77\|C1orf77\|FL-SRAG\|FOP\|SRAG\|SRAG-3\|SRAG-5\|pp7704
	Cytomap	1q21.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	chromatin target of PRMT1 proteinfriend of PRMT1 proteinsmall protein rich in arginine and glycine	chromatin target of PRMT1 proteinfriend of PRMT1 proteinsmall protein rich in arginine and glycine
	Modification date	20180522	20180522
	UniProtAcc	Q9Y3Y2	Q9Y3Y2
	Ensembl transtripts involved in fusion gene	ENST00000368694, ENST00000495554, ENST00000403433, ENST00000368690, ENST00000368687, ENST00000368686,	ENST00000368694, ENST00000495554, ENST00000403433, ENST00000368690, ENST00000368687, ENST00000368686,
Fusion gene scores	* DoF score	3 X 4 X 1=12	2 X 3 X 1=6
	# samples	5	4
	** MAII score	log2(5/12*10)=2.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/6*10)=2.73696559416621
Context	PubMed: CHTOP [Title/Abstract] AND CHTOP [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHTOP	GO:0006406	mRNA export from nucleus	23299939
Hgene	CHTOP	GO:0032781	positive regulation of ATPase activity	23299939
Hgene	CHTOP	GO:0051096	positive regulation of helicase activity	23299939
Tgene	CHTOP	GO:0006406	mRNA export from nucleus	23299939
Tgene	CHTOP	GO:0032781	positive regulation of ATPase activity	23299939
Tgene	CHTOP	GO:0051096	positive regulation of helicase activity	23299939

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE866929	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
ChiTaRS3.1			CA428774	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
ChiTaRS3.1			BU618453	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000368694	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368694	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368694	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-3UTR	ENST00000495554	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
3UTR-intron	ENST00000495554	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000403433	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000403433	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368690	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368690	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368687	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368687	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368694	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-3UTR	ENST00000368686	ENST00000495554	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000403433	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368690	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368687	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
intron-intron	ENST00000368686	ENST00000368686	CHTOP	chr1	153610305	-	CHTOP	chr1	153610310	+
5CDS-3UTR	ENST00000368694	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368694	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368694	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-3UTR	ENST00000495554	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
3UTR-intron	ENST00000495554	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000403433	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000403433	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368690	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368690	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368687	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368687	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000368694	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000495554	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000403433	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000368690	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-3UTR	ENST00000368686	ENST00000368687	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+
5CDS-intron	ENST00000368686	ENST00000368686	CHTOP	chr1	153610836	-	CHTOP	chr1	153617775	+

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FusionProtFeatures for CHTOP_CHTOP

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHTOP Q9Y3Y2	CHTOP Q9Y3Y2

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for CHTOP_CHTOP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHTOP_CHTOP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for CHTOP_CHTOP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CHTOP_CHTOP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Fusion gene ID: 7210

FusionGeneSummary for CHTOP_CHTOP

FusionProtFeatures for CHTOP_CHTOP

FusionGeneSequence for CHTOP_CHTOP

FusionGenePPI for CHTOP_CHTOP

RelatedDrugs for CHTOP_CHTOP

RelatedDiseases for CHTOP_CHTOP