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Fusion gene ID: 7203 |
FusionGeneSummary for CHSY1_SPOCK2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CHSY1_SPOCK2 | Fusion gene ID: 7203 | Hgene | Tgene | Gene symbol | CHSY1 | SPOCK2 | Gene ID | 22856 | 9806 |
Gene name | chondroitin sulfate synthase 1 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 | |
Synonyms | CHSY|CSS1|ChSy-1|TPBS | testican-2 | |
Cytomap | 15q26.3 | 10q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | chondroitin sulfate synthase 1N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1N-acetylgalactosaminyltransferase IIcarbohydrate synthase 1chondroitin glucuronyltransferase 1chondroitin glucuronyltransferase IIchondroitin synthase | testican-2SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q86X52 | Q92563 | |
Ensembl transtripts involved in fusion gene | ENST00000254190, ENST00000543813, | ENST00000536168, ENST00000373109, ENST00000317376, ENST00000460053, ENST00000412663, | |
Fusion gene scores | * DoF score | 5 X 3 X 5=75 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CHSY1 [Title/Abstract] AND SPOCK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CHSY1 | GO:0030206 | chondroitin sulfate biosynthetic process | 11514575 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AO-A03P-01A | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000254190 | ENST00000536168 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
5CDS-intron | ENST00000254190 | ENST00000373109 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
5CDS-intron | ENST00000254190 | ENST00000317376 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
5CDS-intron | ENST00000254190 | ENST00000460053 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
5CDS-intron | ENST00000254190 | ENST00000412663 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
intron-intron | ENST00000543813 | ENST00000536168 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
intron-intron | ENST00000543813 | ENST00000373109 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
intron-intron | ENST00000543813 | ENST00000317376 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
intron-intron | ENST00000543813 | ENST00000460053 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
intron-intron | ENST00000543813 | ENST00000412663 | CHSY1 | chr15 | 101775287 | - | SPOCK2 | chr10 | 73832668 | - |
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FusionProtFeatures for CHSY1_SPOCK2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CHSY1 | SPOCK2 |
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronicacid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc)from UDP-GalNAc to the non-reducing end of the elongatingchondroitin polymer. Involved in the negative control ofosteogenesis likely through the modulation of NOTCH signaling.{ECO:0000269|PubMed:11514575, ECO:0000269|PubMed:21129727}. | May participate in diverse steps of neurogenesis. Bindscalcium. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHSY1_SPOCK2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CHSY1_SPOCK2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CHSY1 | ELAVL1, HLA-DPA1, PEX19, PLAUR, DCN, SDF4, SLC39A4, PTCH1, PON2, GOLT1B, FOXN3, CHSY3, CSGALNACT2, ATP2B2, SCGB2A2, KCNA10, SLC39A12 | SPOCK2 | SPOCK3, PLXNB3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHSY1_SPOCK2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHSY1_SPOCK2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CHSY1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | CHSY1 | C1854466 | Temtamy preaxial brachydactyly syndrome | 1 | ORPHANET;UNIPROT |