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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 720

FusionGeneSummary for ADAM9_UNC5D

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM9_UNC5D
Fusion gene ID: 720
HgeneTgene
Gene symbol

ADAM9

UNC5D

Gene ID

8754

137970

Gene nameADAM metallopeptidase domain 9unc-5 netrin receptor D
SynonymsCORD9|MCMP|MDC9|MltngPRO34692|Unc5h4
Cytomap

8p11.22

8p12

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinasenetrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D
Modification date2018051920180329
UniProtAcc

Q13443

Q6UXZ4

Ensembl transtripts involved in fusion geneENST00000487273, ENST00000466936, 
ENST00000481513, ENST00000484143, 
ENST00000287272, ENST00000453357, 
ENST00000404895, ENST00000420357, 
ENST00000416672, ENST00000449677, 
Fusion gene scores* DoF score13 X 7 X 9=81913 X 7 X 6=546
# samples 1414
** MAII scorelog2(14/819*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/546*10)=-1.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM9 [Title/Abstract] AND UNC5D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM9

GO:0000186

activation of MAPKK activity

17704059

HgeneADAM9

GO:0006509

membrane protein ectodomain proteolysis

9920899

HgeneADAM9

GO:0034612

response to tumor necrosis factor

11831872

HgeneADAM9

GO:0050714

positive regulation of protein secretion

17704059

TgeneUNC5D

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

26235030


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-XF-A8HG-01AADAM9chr8

38884329

+UNC5Dchr8

35406810

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000487273ENST00000287272ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
Frame-shiftENST00000487273ENST00000453357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
Frame-shiftENST00000487273ENST00000404895ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
Frame-shiftENST00000487273ENST00000420357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
Frame-shiftENST00000487273ENST00000416672ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
5CDS-intronENST00000487273ENST00000449677ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000466936ENST00000287272ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000466936ENST00000453357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000466936ENST00000404895ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000466936ENST00000420357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000466936ENST00000416672ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-intronENST00000466936ENST00000449677ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000481513ENST00000287272ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000481513ENST00000453357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000481513ENST00000404895ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000481513ENST00000420357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000481513ENST00000416672ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-intronENST00000481513ENST00000449677ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000484143ENST00000287272ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000484143ENST00000453357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000484143ENST00000404895ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000484143ENST00000420357ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-3CDSENST00000484143ENST00000416672ADAM9chr8

38884329

+UNC5Dchr8

35406810

+
intron-intronENST00000484143ENST00000449677ADAM9chr8

38884329

+UNC5Dchr8

35406810

+

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FusionProtFeatures for ADAM9_UNC5D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM9

Q13443

UNC5D

Q6UXZ4

Cleaves and releases a number of molecules withimportant roles in tumorigenesis and angiogenesis, such as TEK,KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells viainteractions with integrins. {ECO:0000250|UniProtKB:Q61072}. Isoform 2: May act as alpha-secretase for amyloidprecursor protein (APP). {ECO:0000269|PubMed:12054541}. Receptor for the netrin NTN4 that promotes neuronal cellsurvival (By similarity). Plays a role in cell-cell adhesion andcell guidance. Receptor for netrin involved in cell migration.Plays a role in axon guidance by mediating axon repulsion ofneuronal growth cones in the developing nervous system upon ligandbinding (By similarity). May play a role in apoptosis in responseto DNA damage (PubMed:24691657). It also acts as a dependencereceptor required for apoptosis induction when not associated withnetrin ligand (PubMed:24519068). Mediates cell-cell adhesion viaits interaction with FLRT3 on an adjacent cell (By similarity).{ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068,ECO:0000305|PubMed:24691657}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAM9_UNC5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAM9_UNC5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAM9MAD2L2, SH3GL2, SNX9, PRKCD, CDH1, RNF2, CD1B, FIGF, TMEM25, PTPRK, GPHA2, CLPSL1, NUDC, KIF2C, ITGAV, ITGB5, SCGB1D4, ADAM32, LYZL2, INSL5, SLAMF1, LYZL1UNC5D


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAM9_UNC5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAM9_UNC5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM9C0033578Prostatic Neoplasms1CTD_human