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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7192

FusionGeneSummary for CHST6_COTL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHST6_COTL1
Fusion gene ID: 7192
HgeneTgene
Gene symbol

CHST6

COTL1

Gene ID

4166

23406

Gene namecarbohydrate sulfotransferase 6coactosin like F-actin binding protein 1
SynonymsMCDC1CLP
Cytomap

16q23.1

16q24.1

Type of geneprotein-codingprotein-coding
Descriptioncarbohydrate sulfotransferase 6C-GlcNAc6STGST4-betaN-acetylglucosamine 6-O-sulfotransferase 5N-acetylglucosamine 6-sulfotransferasecarbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6corneal N-acetylglucosamine 6-sulfotransferasecorneal N-acetcoactosin-like proteincoactosin-like 1
Modification date2018052320180519
UniProtAcc

Q9GZX3

Q14019

Ensembl transtripts involved in fusion geneENST00000332272, ENST00000390664, 
ENST00000262428, ENST00000567278, 
ENST00000564057, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 3 X 3=36
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHST6 [Title/Abstract] AND COTL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHST6

GO:0006044

N-acetylglucosamine metabolic process

11352640

HgeneCHST6

GO:0006790

sulfur compound metabolic process

11352640

HgeneCHST6

GO:0018146

keratan sulfate biosynthetic process

11278593


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF219990CHST6chr16

75512350

-COTL1chr16

84599653

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000332272ENST00000262428CHST6chr16

75512350

-COTL1chr16

84599653

-
intron-5UTRENST00000332272ENST00000567278CHST6chr16

75512350

-COTL1chr16

84599653

-
intron-3UTRENST00000332272ENST00000564057CHST6chr16

75512350

-COTL1chr16

84599653

-
intron-3UTRENST00000390664ENST00000262428CHST6chr16

75512350

-COTL1chr16

84599653

-
intron-5UTRENST00000390664ENST00000567278CHST6chr16

75512350

-COTL1chr16

84599653

-
intron-3UTRENST00000390664ENST00000564057CHST6chr16

75512350

-COTL1chr16

84599653

-

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FusionProtFeatures for CHST6_COTL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHST6

Q9GZX3

COTL1

Q14019

Sulfotransferase that utilizes 3'-phospho-5'-adenylylsulfate (PAPS) as sulfonate donor to catalyze the transfer ofsulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc)residues of keratan. Mediates sulfation of keratan in cornea.Keratan sulfate plays a central role in maintaining cornealtransparency. Acts on the non-reducing terminal GlcNAc of shortand long carbohydrate substrates that have poly-N-acetyllactosamine structures. {ECO:0000269|PubMed:11352640,ECO:0000269|PubMed:12218059}. Binds to F-actin in a calcium-independent manner. Has nodirect effect on actin depolymerization. Acts as a chaperone forALOX5 (5LO), influencing both its stability and activity inleukotrienes synthesis. {ECO:0000269|PubMed:11583571,ECO:0000269|PubMed:19807693}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHST6_COTL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHST6_COTL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHST6_COTL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHST6_COTL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHST6C1636149Macular dystrophy, corneal type 113CTD_human;UNIPROT
TgeneCOTL1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCOTL1C1458155Mammary Neoplasms1CTD_human