FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 719

FusionGeneSummary for ADAM9_TACC1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM9_TACC1
Fusion gene ID: 719
HgeneTgene
Gene symbol

ADAM9

TACC1

Gene ID

8754

6867

Gene nameADAM metallopeptidase domain 9transforming acidic coiled-coil containing protein 1
SynonymsCORD9|MCMP|MDC9|MltngGa55
Cytomap

8p11.22

8p11.22

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 9ADAM metallopeptidase domain 9 (meltrin gamma)cellular disintegrin-related proteincone rod dystrophy 9metalloprotease/disintegrin/cysteine-rich protein 9myeloma cell metalloproteinasetransforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1
Modification date2018051920180523
UniProtAcc

Q13443

O75410

Ensembl transtripts involved in fusion geneENST00000487273, ENST00000466936, 
ENST00000481513, ENST00000484143, 
ENST00000519416, ENST00000520615, 
ENST00000443286, ENST00000520340, 
ENST00000518415, ENST00000522752, 
ENST00000348567, ENST00000330691, 
ENST00000317827, ENST00000379931, 
ENST00000276520, ENST00000520973, 
ENST00000520611, 
Fusion gene scores* DoF score13 X 7 X 9=81914 X 13 X 8=1456
# samples 1415
** MAII scorelog2(14/819*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1456*10)=-3.27897594970282
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADAM9 [Title/Abstract] AND TACC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM9

GO:0000186

activation of MAPKK activity

17704059

HgeneADAM9

GO:0006509

membrane protein ectodomain proteolysis

9920899

HgeneADAM9

GO:0034612

response to tumor necrosis factor

11831872

HgeneADAM9

GO:0050714

positive regulation of protein secretion

17704059


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7660-01AADAM9chr8

38865502

+TACC1chr8

38602413

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000487273ENST00000519416ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000520615ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000443286ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000520340ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-5UTRENST00000487273ENST00000518415ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000522752ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000348567ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000330691ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000317827ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000379931ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000276520ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000520973ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000487273ENST00000520611ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000519416ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000520615ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000443286ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000520340ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-5UTRENST00000466936ENST00000518415ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000522752ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000348567ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000330691ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000317827ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000379931ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000276520ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000520973ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000466936ENST00000520611ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000519416ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000520615ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000443286ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000520340ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-5UTRENST00000481513ENST00000518415ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000522752ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000348567ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000330691ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000317827ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000379931ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000276520ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000520973ADAM9chr8

38865502

+TACC1chr8

38602413

+
5CDS-intronENST00000481513ENST00000520611ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000519416ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000520615ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000443286ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000520340ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-5UTRENST00000484143ENST00000518415ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000522752ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000348567ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000330691ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000317827ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000379931ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000276520ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000520973ADAM9chr8

38865502

+TACC1chr8

38602413

+
intron-intronENST00000484143ENST00000520611ADAM9chr8

38865502

+TACC1chr8

38602413

+

Top

FusionProtFeatures for ADAM9_TACC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM9

Q13443

TACC1

O75410

Cleaves and releases a number of molecules withimportant roles in tumorigenesis and angiogenesis, such as TEK,KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells viainteractions with integrins. {ECO:0000250|UniProtKB:Q61072}. Isoform 2: May act as alpha-secretase for amyloidprecursor protein (APP). {ECO:0000269|PubMed:12054541}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ADAM9_TACC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ADAM9_TACC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAM9MAD2L2, SH3GL2, SNX9, PRKCD, CDH1, RNF2, CD1B, FIGF, TMEM25, PTPRK, GPHA2, CLPSL1, NUDC, KIF2C, ITGAV, ITGB5, SCGB1D4, ADAM32, LYZL2, INSL5, SLAMF1, LYZL1TACC1YEATS4, AURKB, AURKA, LSM7, TDRD7, CKAP5, SNRPG, BARD1, KAT2A, ITSN2, NIF3L1, S100A11, SLC9A3R1, C12orf57, PLXNB2, HTT, KDM1A, FBXW11, PRKRIR, STX5, BTRC, MEMO1, SH2D4A, DTNBP1, VAPB, LYST, VAPA, BRD3, RB1CC1, TACC2, BAIAP2L1, STAT2, RNF41, POC1B, KNSTRN, RPN2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ADAM9_TACC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ADAM9_TACC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADAM9C0033578Prostatic Neoplasms1CTD_human