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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7182

FusionGeneSummary for CHST11_IGHG1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHST11_IGHG1
Fusion gene ID: 7182
HgeneTgene
Gene symbol

CHST11

IGHG1

Gene ID

50515

3500

Gene namecarbohydrate sulfotransferase 11immunoglobulin heavy constant gamma 1 (G1m marker)
SynonymsC4ST|C4ST-1|C4ST1|HSA269537-
Cytomap

12q23.3

14q32.33

Type of geneprotein-codingother
Descriptioncarbohydrate sulfotransferase 11C4S-1IgH/CHST11 fusioncarbohydrate (chondroitin 4) sulfotransferase 11chondroitin 4-O-sulfotransferase 1constant region of heavy chain of IgG1immunoglobulin gamma 1 (Gm marker)
Modification date2018051920180523
UniProtAcc

Q9NPF2

P01857

Ensembl transtripts involved in fusion geneENST00000547956, ENST00000549260, 
ENST00000303694, ENST00000546689, 
ENST00000550711, 
ENST00000390548, 
Fusion gene scores* DoF score11 X 7 X 5=38532 X 42 X 3=4032
# samples 1246
** MAII scorelog2(12/385*10)=-1.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(46/4032*10)=-3.13178987255554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHST11 [Title/Abstract] AND IGHG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHST11

GO:0030206

chondroitin sulfate biosynthetic process

11056388


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AY533203CHST11chr12

104851292

+IGHG1chr14

106225927

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000547956ENST00000390548CHST11chr12

104851292

+IGHG1chr14

106225927

+
5CDS-intronENST00000549260ENST00000390548CHST11chr12

104851292

+IGHG1chr14

106225927

+
5CDS-intronENST00000303694ENST00000390548CHST11chr12

104851292

+IGHG1chr14

106225927

+
5CDS-intronENST00000546689ENST00000390548CHST11chr12

104851292

+IGHG1chr14

106225927

+
intron-intronENST00000550711ENST00000390548CHST11chr12

104851292

+IGHG1chr14

106225927

+

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FusionProtFeatures for CHST11_IGHG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHST11

Q9NPF2

IGHG1

P01857

Catalyzes the transfer of sulfate to position 4 of theN-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitinsulfate constitutes the predominant proteoglycan present incartilage and is distributed on the surfaces of many cells andextracellular matrices. Can also sulfate Gal residues indesulfated dermatan sulfate. Preferentially sulfates inGlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as anacceptor. Constant region of immunoglobulin heavy chains.Immunoglobulins, also known as antibodies, are membrane-bound orsecreted glycoproteins produced by B lymphocytes. In therecognition phase of humoral immunity, the membrane-boundimmunoglobulins serve as receptors which, upon binding of aspecific antigen, trigger the clonal expansion and differentiationof B lymphocytes into immunoglobulins-secreting plasma cells.Secreted immunoglobulins mediate the effector phase of humoralimmunity, which results in the elimination of bound antigens(PubMed:22158414, PubMed:20176268). The antigen binding site isformed by the variable domain of one heavy chain, together withthat of its associated light chain. Thus, each immunoglobulin hastwo antigen binding sites with remarkable affinity for aparticular antigen. The variable domains are assembled by aprocess called V-(D)-J rearrangement and can then be subjected tosomatic hypermutations which, after exposure to antigen andselection, allow affinity maturation for a particular antigen(PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170,ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHST11_IGHG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHST11_IGHG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHST11_IGHG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHST11_IGHG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIGHG1C0027121Myositis1CTD_human
TgeneIGHG1C0032460Polycystic Ovary Syndrome1CTD_human