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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7138

FusionGeneSummary for CHN2_TAX1BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHN2_TAX1BP1
Fusion gene ID: 7138
HgeneTgene
Gene symbol

CHN2

TAX1BP1

Gene ID

1124

8887

Gene namechimerin 2Tax1 binding protein 1
SynonymsARHGAP3|BCH|CHN2-3|RHOGAP3CALCOCO3|T6BP|TXBP151
Cytomap

7p14.3

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionbeta-chimaerinbeta-chimerinbeta3-chimaerinchimerin (chimaerin) 2chimerin, beta-2chimerin, testis-specificrho-GTPase-activating protein 3tax1-binding protein 1TRAF6-binding proteinTax1 (human T-cell leukemia virus type I) binding protein 1
Modification date2018051920180522
UniProtAcc

P52757

Q86VP1

Ensembl transtripts involved in fusion geneENST00000539406, ENST00000222792, 
ENST00000435288, ENST00000495789, 
ENST00000539389, ENST00000546235, 
ENST00000409041, ENST00000424025, 
ENST00000439711, ENST00000421775, 
ENST00000410098, 		ENST00000543117, 
ENST00000265393, ENST00000409980, 
ENST00000433216, ENST00000396319, 
ENST00000494033, 
Fusion gene scores* DoF score3 X 2 X 3=185 X 4 X 3=60
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHN2 [Title/Abstract] AND TAX1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A92D-01ACHN2chr7

29234606

+TAX1BP1chr7

27824782

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000539406ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000539406ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000539406ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000539406ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000539406ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000539406ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000222792ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000222792ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000222792ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000222792ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000222792ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
5CDS-intronENST00000222792ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000435288ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000435288ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000435288ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000435288ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000435288ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
5CDS-intronENST00000435288ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000495789ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000495789ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000495789ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000495789ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000495789ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
5CDS-intronENST00000495789ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000539389ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000539389ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000539389ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000539389ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
Frame-shiftENST00000539389ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
5CDS-intronENST00000539389ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000546235ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000546235ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000546235ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000546235ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000546235ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000546235ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000409041ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000409041ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000409041ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000409041ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000409041ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000409041ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000424025ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000424025ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000424025ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000424025ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000424025ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000424025ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000439711ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000439711ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000439711ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000439711ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000439711ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000439711ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000421775ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000421775ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000421775ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000421775ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000421775ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000421775ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000410098ENST00000543117CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000410098ENST00000265393CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000410098ENST00000409980CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000410098ENST00000433216CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-3CDSENST00000410098ENST00000396319CHN2chr7

29234606

+TAX1BP1chr7

27824782

+
intron-intronENST00000410098ENST00000494033CHN2chr7

29234606

+TAX1BP1chr7

27824782

+

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FusionProtFeatures for CHN2_TAX1BP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHN2

P52757

TAX1BP1

Q86VP1


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHN2_TAX1BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CHN2_TAX1BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHN2BAG6, RAC1, ERBB3, RANBP3, RB1, SMARCD1, TP53RK, CHN1, PTGDSTAX1BP1TNFAIP3, STARD13, TBC1D17, TRAF6, RNF11, RIPK1, OPTN, TNIP1, IKBKE, TBK1, TRAF3, GABRR1, ITCH, MYO6, CALCOCO2, UBC, VCP, PARK2, ORC5, IKBKG, MAP1LC3B, MAP1LC3C, GABARAP, FOXC2, KIF5B, LGALS8, SSX2, TCEA2, TSG101, FAM189A2, DAZAP2, DSTN, EMILIN1, RAB18, FAM168A, CXXC1, NMRK1, LMO3, RAD18, TSHZ3, MRPL11, TNIP3, PLEKHN1, COG7, MRPL53, CWF19L2, REEP4, FHL5, RNF126, HSD17B3, FAM58A, LDLRAD4, NTRK1, MED4, RAD54L2, HNRNPD, UBE2A, AGO1, GABARAPL1, GABARAPL2, RFWD2, RABGEF1, SLC22A23, KDELR1, RNF115, DNAJC11, SLC5A12, RNF26, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHN2_TAX1BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CHN2_TAX1BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHN2C0023903Liver neoplasms1CTD_human
HgeneCHN2C0032927Precancerous Conditions1CTD_human