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Fusion gene ID: 7055 |
FusionGeneSummary for CHGA_RBM14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHGA_RBM14 | Fusion gene ID: 7055 | Hgene | Tgene | Gene symbol | CHGA | RBM14 | Gene ID | 1113 | 10432 |
| Gene name | chromogranin A | RNA binding motif protein 14 | |
| Synonyms | CGA | COAA|PSP2|SIP|SYTIP1|TMEM137 | |
| Cytomap | 14q32.12 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I | RNA-binding protein 14RRM-containing coactivator activator/modulatorSYT-interacting proteinparaspeckle protein 2synaptotagmin-interacting proteintransmembrane protein 137 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P10645 | Q96PK6 | |
| Ensembl transtripts involved in fusion gene | ENST00000216492, ENST00000334654, ENST00000553866, | ENST00000310137, ENST00000393979, ENST00000409372, ENST00000443702, ENST00000409738, ENST00000461478, | |
| Fusion gene scores | * DoF score | 3 X 5 X 1=15 | 7 X 5 X 4=140 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/15*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/140*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHGA [Title/Abstract] AND RBM14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CHGA | GO:0002551 | mast cell chemotaxis | 21214543 |
| Hgene | CHGA | GO:0032762 | mast cell cytokine production | 21214543 |
| Hgene | CHGA | GO:0033604 | negative regulation of catecholamine secretion | 15326220 |
| Hgene | CHGA | GO:0043303 | mast cell degranulation | 21214543 |
| Hgene | CHGA | GO:0045576 | mast cell activation | 21214543 |
| Hgene | CHGA | GO:0050829 | defense response to Gram-negative bacterium | 15723172 |
| Hgene | CHGA | GO:0050830 | defense response to Gram-positive bacterium | 15723172 |
| Tgene | RBM14 | GO:0002218 | activation of innate immune response | 28712728 |
| Tgene | RBM14 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11443112|15919756 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE467850 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000216492 | ENST00000310137 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-3UTR | ENST00000216492 | ENST00000393979 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000216492 | ENST00000409372 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000216492 | ENST00000443702 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000216492 | ENST00000409738 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000216492 | ENST00000461478 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-3UTR | ENST00000334654 | ENST00000310137 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-3UTR | ENST00000334654 | ENST00000393979 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000334654 | ENST00000409372 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000334654 | ENST00000443702 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000334654 | ENST00000409738 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| 3UTR-intron | ENST00000334654 | ENST00000461478 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| intron-3UTR | ENST00000553866 | ENST00000310137 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| intron-3UTR | ENST00000553866 | ENST00000393979 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| intron-intron | ENST00000553866 | ENST00000409372 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| intron-intron | ENST00000553866 | ENST00000443702 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| intron-intron | ENST00000553866 | ENST00000409738 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
| intron-intron | ENST00000553866 | ENST00000461478 | CHGA | chr14 | 93401572 | - | RBM14 | chr11 | 66394194 | + |
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FusionProtFeatures for CHGA_RBM14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHGA | RBM14 |
| Pancreastatin: Strongly inhibits glucose induced insulinrelease from the pancreas. Catestatin: Inhibits catecholamine release fromchromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220).Displays antibacterial activity against Gram-positive bacteriaS.aureus and M.luteus, and Gram-negative bacteria E.coli andP.aeruginosa (PubMed:15723172 and PubMed:24723458). Can inducemast cell migration, degranulation and production of cytokines andchemokines (PubMed:21214543). Acts as a potent scavenger of freeradicals in vitro (PubMed:24723458). May play a role in theregulation of cardiac function and blood pressure(PubMed:18541522). {ECO:0000269|PubMed:15326220,ECO:0000269|PubMed:15723172, ECO:0000269|PubMed:21214543,ECO:0000269|PubMed:24723458, ECO:0000303|PubMed:18541522}. Serpinin: Regulates granule biogenesis in endocrinecells by up-regulating the transcription of protease nexin 1(SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition ofgranule protein degradation in the Golgi complex which in turnpromotes granule formation. {ECO:0000250|UniProtKB:P26339}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CHGA_RBM14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CHGA_RBM14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHGA_RBM14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHGA_RBM14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CHGA | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Hgene | CHGA | C0031511 | Pheochromocytoma | 1 | CTD_human |
| Hgene | CHGA | C0036341 | Schizophrenia | 1 | PSYGENET |
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