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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 7045

FusionGeneSummary for CHEK2_THOC5

check button Fusion gene summary
Fusion gene informationFusion gene name: CHEK2_THOC5
Fusion gene ID: 7045
HgeneTgene
Gene symbol

CHEK2

THOC5

Gene ID

11200

8563

Gene namecheckpoint kinase 2THO complex 5
SynonymsCDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1C22orf19|Fmip|PK1.3|fSAP79
Cytomap

22q12.1

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2THO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2
Modification date2018052720180523
UniProtAcc

O96017

Q13769

Ensembl transtripts involved in fusion geneENST00000382565, ENST00000382578, 
ENST00000382566, ENST00000348295, 
ENST00000544772, ENST00000404276, 
ENST00000328354, ENST00000405598, 
ENST00000382580, ENST00000402731, 
ENST00000403642, ENST00000464581, 
ENST00000490103, ENST00000397871, 
ENST00000397872, ENST00000397873, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CHEK2 [Title/Abstract] AND THOC5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHEK2

GO:0006355

regulation of transcription, DNA-templated

12717439

HgeneCHEK2

GO:0006468

protein phosphorylation

12717439

HgeneCHEK2

GO:0006974

cellular response to DNA damage stimulus

24550317

HgeneCHEK2

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

12402044

HgeneCHEK2

GO:0042770

signal transduction in response to DNA damage

14744935

HgeneCHEK2

GO:0045893

positive regulation of transcription, DNA-templated

17101782

HgeneCHEK2

GO:0046777

protein autophosphorylation

16794575|18644861

HgeneCHEK2

GO:0050821

protein stabilization

12717439

TgeneTHOC5

GO:0006406

mRNA export from nucleus

17190602

TgeneTHOC5

GO:0030224

monocyte differentiation

19015024

TgeneTHOC5

GO:0046784

viral mRNA export from host cell nucleus

18974867


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCSTCGA-NF-A4WX-01ACHEK2chr22

29085123

-THOC5chr22

29932727

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000382565ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382565ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382565ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382565ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382578ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382578ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382578ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382578ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000348295ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000348295ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000348295ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000348295ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000404276ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000404276ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000404276ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000404276ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000328354ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000328354ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000328354ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000328354ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000405598ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000405598ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000405598ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000405598ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382580ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382580ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382580ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000382580ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000402731ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000402731ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000402731ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000402731ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000403642ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000403642ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000403642ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shitENST00000403642ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-

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FusionProtFeatures for CHEK2_THOC5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHEK2

O96017

THOC5

Q13769

Acts as component of the THO subcomplex of the TREXcomplex which is thought to couple mRNA transcription, processingand nuclear export, and which specifically associates with splicedmRNA and not with unspliced pre-mRNA. TREX is recruited to splicedmRNAs by a transcription-independent mechanism, binds to mRNAupstream of the exon-junction complex (EJC) and is recruited in asplicing- and cap-dependent manner to a region near the 5' end ofthe mRNA where it functions in mRNA export to the cytoplasm viathe TAP/NFX1 pathway. The TREX complex is essential for the exportof Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAsand infectious virus production. THOC5 in conjunction withALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export ofHSP70 mRNA; both proteins enhance the RNA binding activity of NXF1and are required for NXF1 localization to the nuclear rim.Involved in transcription elongation and genome stability.Involved in alternative polyadenylation site choice by recruitingCPSF6 to 5' region of target genes; probably mediates associationof the TREX and CFIm complexes. Regulates the expression of myeloid transcriptionfactors CEBPA, CEBPB and GAB2 by enhancing the levels ofphosphatidylinositol 3,4,5-trisphosphate. May be involved in thedifferentiation of granulocytes and adipocytes. Essential forhematopoietic primitive cell survival and plays an integral rolein monocytic development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CHEK2_THOC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000490103_chr22_29932727_-_484aa
AGREVPRVPI_QGEDSQGD_GEEGVPEQPPAPPQQHHAGFPSGAGVPVTAIRPGSQAV_DSQTPAASPLCPLCSGHCVWAGL__DVICGN
RRQCG_SQGSVQTSRGLPR_RE_LRCRGGADYEAPETHTGGSVGRQTQGDAEEAPTVCHARPEVQR_QCASPDFLLPHEPQHHDSKSQSD
NCHGADHPHQCR_LAVS_LSPELLVSWGSWKENSESSQSVSV__SWHPDFERLCT_ARSPLFVGAEAGWPPLPQRAAPANSDC_PLAERQ
PHGDHHETSEDQGAVPPGPPQTVCIPRTWHCASYQ_LPVPLPCQGCLSPGEMGDSCP_GLHGAALHQRHCGCGTGWGHQSLLHGAHRKGH
SQTAGRCGVEPWLLLHPTCFPALFELERGENQQQR_QHSGHGGRSQCVLQGAVWPLAQPPAVDQPAAAAVCAAGCLPGDREP_RQCGGAQ

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397871_chr22_29932727_-_484aa
AGREVPRVPI_QGEDSQGD_GEEGVPEQPPAPPQQHHAGFPSGAGVPVTAIRPGSQAV_DSQTPAASPLCPLCSGHCVWAGL__DVICGN
RRQCG_SQGSVQTSRGLPR_RE_LRCRGGADYEAPETHTGGSVGRQTQGDAEEAPTVCHARPEVQR_QCASPDFLLPHEPQHHDSKSQSD
NCHGADHPHQCR_LAVS_LSPELLVSWGSWKENSESSQSVSV__SWHPDFERLCT_ARSPLFVGAEAGWPPLPQRAAPANSDC_PLAERQ
PHGDHHETSEDQGAVPPGPPQTVCIPRTWHCASYQ_LPVPLPCQGCLSPGEMGDSCP_GLHGAALHQRHCGCGTGWGHQSLLHGAHRKGH
SQTAGRCGVEPWLLLHPTCFPALFELERGENQQQR_QHSGHGGRSQCVLQGAVWPLAQPPAVDQPAAAAVCAAGCLPGDREP_RQCGGAQ

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397872_chr22_29932727_-_484aa
AGREVPRVPI_QGEDSQGD_GEEGVPEQPPAPPQQHHAGFPSGAGVPVTAIRPGSQAV_DSQTPAASPLCPLCSGHCVWAGL__DVICGN
RRQCG_SQGSVQTSRGLPR_RE_LRCRGGADYEAPETHTGGSVGRQTQGDAEEAPTVCHARPEVQR_QCASPDFLLPHEPQHHDSKSQSD
NCHGADHPHQCR_LAVS_LSPELLVSWGSWKENSESSQSVSV__SWHPDFERLCT_ARSPLFVGAEAGWPPLPQRAAPANSDC_PLAERQ
PHGDHHETSEDQGAVPPGPPQTVCIPRTWHCASYQ_LPVPLPCQGCLSPGEMGDSCP_GLHGAALHQRHCGCGTGWGHQSLLHGAHRKGH
SQTAGRCGVEPWLLLHPTCFPALFELERGENQQQR_QHSGHGGRSQCVLQGAVWPLAQPPAVDQPAAAAVCAAGCLPGDREP_RQCGGAQ

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397873_chr22_29932727_-_484aa
AGREVPRVPI_QGEDSQGD_GEEGVPEQPPAPPQQHHAGFPSGAGVPVTAIRPGSQAV_DSQTPAASPLCPLCSGHCVWAGL__DVICGN
RRQCG_SQGSVQTSRGLPR_RE_LRCRGGADYEAPETHTGGSVGRQTQGDAEEAPTVCHARPEVQR_QCASPDFLLPHEPQHHDSKSQSD
NCHGADHPHQCR_LAVS_LSPELLVSWGSWKENSESSQSVSV__SWHPDFERLCT_ARSPLFVGAEAGWPPLPQRAAPANSDC_PLAERQ
PHGDHHETSEDQGAVPPGPPQTVCIPRTWHCASYQ_LPVPLPCQGCLSPGEMGDSCP_GLHGAALHQRHCGCGTGWGHQSLLHGAHRKGH
SQTAGRCGVEPWLLLHPTCFPALFELERGENQQQR_QHSGHGGRSQCVLQGAVWPLAQPPAVDQPAAAAVCAAGCLPGDREP_RQCGGAQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000490103_chr22_29932727_-_1453nt
GCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCA
GCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGAC
AGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAAT
CGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCA
GACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCT
CGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGAC
AACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGG
AAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCC
CTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAG
CCACATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCAT
TGTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTA
CATGGAGCTGCACTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCAC
AGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAA
AACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCA
GCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAA
GGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTT

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397871_chr22_29932727_-_1453nt
GCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCA
GCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGAC
AGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAAT
CGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCA
GACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCT
CGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGAC
AACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGG
AAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCC
CTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAG
CCACATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCAT
TGTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTA
CATGGAGCTGCACTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCAC
AGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAA
AACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCA
GCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAA
GGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTT

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397872_chr22_29932727_-_1453nt
GCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCA
GCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGAC
AGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAAT
CGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCA
GACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCT
CGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGAC
AACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGG
AAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCC
CTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAG
CCACATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCAT
TGTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTA
CATGGAGCTGCACTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCAC
AGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAA
AACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCA
GCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAA
GGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTT

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397873_chr22_29932727_-_1453nt
GCTGGCAGAGAAGTACCGAGAGTGCCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCA
GCCCCGCCTCAACAGCATCATGCAGGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGAC
AGCCAGACACCTGCCGCCTCCCCTCTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAAT
CGAAGGCAGTGTGGATGAAGCCAAGGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCA
GACTACGAAGCGCCGGAGACCCACACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCT
CGACCTGAAGTGCAAAGATGACAGTGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGAC
AACTGCCATGGAGCTGATCACCCCCATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGG
AAAGAAAACTCCGAATCCAGCCAATCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCC
CTATTTGTGGGTGCAGAAGCTGGGTGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAG
CCACATGGAGACCACCATGAAACTTCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCAT
TGTGCCAGTTACCAGTGATTGCCAGTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTA
CATGGAGCTGCACTTCACCAAAGACATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCAC
AGCCAAACTGCAGGCCGCTGTGGTGTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAA
AACCAACAGCAACGATGACAACATTCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCA
GCTGTTGACCAACCAGCTGCAGCGGCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAA
GGAATTTCCCCAGGAGAAGATGTGTCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000490103_chr22_29932727_-_6347nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA
GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC
ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG
CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG
AGATGCTCACCTCTTGTCTACGCACACCCTATTTGTGCTTTGCGGGGTGAGGTCCTCATGATCTTGTATTTATTATCCCAAGTTCCTGCT
GTTAAGAGGTGGTAGGAGAAGCCAAAGGCAGCAGAGCACAAAAAGCAAAACTCTTCCCTCCCCACCCGCTCTTCCCATTAGTCCTGTCAG
GGTTGCCGATGGACAAATTGTCTCTGATCGTTGGATGTTATAAATGTCTGACAGTGCAGTGCAAACAGAAGACAAACTCAGTTGATCCTT
GAACAACTCAGGGGTTAGGGGCACCAACACCCCCTGCCCTGCACAGTTGAAAAATCCGTGTATAACTTTTGACTCCCTAAAAACTTAACT
AATAGCCTGCTGTTGACCAGTAGTATGCTATTAGTAGTTACTTACTGCTAACATAGTCAGTACATATTTTCAGTATATATTTTGTATCTT
ATACACTGTATTCTTACAATACAGTAAACTAGAGAAAAGAAAATGTTATAAGGAAAGTCACAAGGGGGCCTGAGTGCAGTGGCTCACGTC
TGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCGACATGGTGAAACCCTGT
CTCTACTAAAAACATGGAAATTAGCCAAGCGTGGTGGCGCATGCCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGAATTACTTGAACC
CATGAGGCAGAGGTTGCAGTAAGCCAAGATCACGCTCCTGCGCTCCGGCTTGGGCGAGAGTGAGACTCCGTCTCAAAAATAAATAAATAA
GAAAGCCATAAGGAAGAAAATATATATCTACTATTAAGTAGAAGTGGATCACCATAAAGGTCTTCACATACTGTCTCAGGGTTGAATAGT
CTAAGGAAGAGGAGGGGTTGGTCTTGGTGTCTCAGGGATGGCAGAGGCAGAAAAAGTGGGGGAGGTGGAGGGGGAGGCAGGCACCACTGT
TATTTTTATTGAACAAAATCTGTGCAGGGACTCATGACTGTAATCCTAGTACTTTGGAAAGCTAAGGCGGGAGGATCCCTTGAGGCCAGG
AGTTCAGGTCCAGCCTGGGCAACGTAGTGAGAGACCCTGTATCTACAAAAAATTTAAAAATCAGCCAGGTGTGGTGGTATGCACCAATAG
TCCCAGTTACTCAGAAGGCTGAGGTGGGCGGATGACTGGAGTCCAGGAGTTCAAGGTAGCAGTGAGCTATTCATCGTGCCTGTACTGTAC
TCCAGCCTGGGAAACAATGCGAGTCCCTATCTCTAAAAAATTTTAAAAAAAGAAATCTGCATATAATAGACCCACAGAGTCCAAACTATT
GTTCAGAGATCAACTGTACTTCACAGAGAGTAATTCTAAGTCTTACAGGATTTCATGGAGATGGCGAGAGTGGTGTTGGAGAATCAATCA
CATACAGAGATACAGGACAGTGAGACCAGGTAACATTTGAGGAGAATATTTTTTTTTTATTGAGACAGGGTCTTGCTCTGTTGTCCAGGC
TGGAGTGCAGTGGCACGAACACAGCTCACTGCCGCCTCAACCTCTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGG
GACCACAGGTGTGTGCCACCATTTCTGGCTAATTTTTAAATTTTTTGTAGAGGCGGGATCCCACTATTTTTCCCAGGCTGGTCTCAAACT
CCTGGGCTCAAATGATCCTCCCACCTCGGCCTCCCAAAGTGCTAGGATTATAGGCATGAGCCACCACACCCGGCCTGAGTAGAGTCTTTA
AGGTAATGACAAAAGTGCCTCAAAATATAATTATTTGATTAAGAGAAGTCTTGGGAAGATAGGTAACAACCTTTAAAATGTTCATAAAAT
TACATCCTTTGTAATACTCCTGCAAGTCAAAGTAAAGGATGGCATAGACTATTCTTGGACAGTTTTGTCAAAAAGTGTATCTTGACCCCA
CCATCAGTACTCCATTCTTCATTTTAAAAAATAAGATGGGCTGGGCACAGTGGCTTACGCCTTTAATATCAGTACTTTGGGAGGCTGGTG
GGCGGATCACCTGAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCA
TGGTGGTGCGCGCCTGTAATCCCAGCCACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCCCGAGGCGGAGGTTGCACTGAGCCGAG

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397871_chr22_29932727_-_4058nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA
GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC
ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG
CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397872_chr22_29932727_-_4058nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA
GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC
ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG
CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG

>In-frame_CHEK2_ENST00000544772_chr22_29085123_-_THOC5_ENST00000397873_chr22_29932727_-_3868nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA


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FusionGenePPI for CHEK2_THOC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHEK2MSH2, BRCA1, MDC1, PLK3, PLK1, GINS2, VCP, BRCA2, RAD50, TP53BP1, MUS81, CDC25A, MDM2, MDM4, FOXM1, ATR, CDC25C, REV3L, TP53, ATM, AATF, CHEK2, PPP2R2B, PPP2R5A, PPP2R5D, PPP2R5C, PPP2R5E, PPP2R5B, PPP2R1A, PPP2CA, ELAVL1, TRIM28, RNF8, PSME3, LATS2, KAT2B, PML, UBR5, DAPK3, RB1, KPNA2, APP, STRAP, CUL4A, CUL1, PER3, RCHY1, VHL, PRKDC, NR4A1, POLR2L, ARHGAP1, SRPK1, TEX264, SIRT1, CCAR2, ILKAP, MAPK1, MAPK3, BEX1, CCL5, CDH13, CYP17A1, DIRAS3, FAM84B, HOXC6, IL24, ITIH5, KLK7, KLK9, LYPD3, PRDM14, PSMC3IP, RHOBTB2, RNF20, ST14, WHSC1L1, BAALC, ENO1, GNAS, HMGN1, SLC25A6, PRMT2, STMN1, TLR3, SRPK2, FOS, FOXK1, FOXK2, SIAH2, ERBB2, KMT2D, CDK4, TP63, WEE1, CHEK1, CDC6, CDC73, BLM, RFC1, RAD17, FZR1, ATAD5, LLGL1, CDC14A, RPS10, WRN, DAAM1, TTN, BRD4, TUBA1A, PPM1DTHOC5DDX39B, ALYREF, THOC2, THOC1, THOC3, THOC6, THOC7, SMAD4, NCBP1, NXF1, DDX23, ZC3H15, XPO4, ZKSCAN5, VIM, RRP9, UTRN, ZPR1, ZNF606, TJP2, UBR7, LIG4, LSM3, PPIL1, ZNF830, CSNK2A1, RNF2, LUZP4, HSPB1, TJP1, FMNL1, GTF2F1, PDGFRA, RPL6, RPL22, RPL27A, HSF2, BCLAF1, C17orf85, NEMF, EIF4A3, ZC3H11A, DDX39A, KIF1C, MRPS27, SIRT1, CCDC9, CHTOP, WDR74, MAGOHB, DDX24, KIAA1522, MYO1G, ZC3H14, KLF16, FYTTD1, POLDIP3, SERPINB12, IMP4, C19orf47, MRPL12, SARNP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CHEK2_THOC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CHEK2_THOC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCHEK2C1836482Li-Fraumeni Syndrome 26CTD_human;UNIPROT
HgeneCHEK2C0376358Malignant neoplasm of prostate4UNIPROT
HgeneCHEK2C1458155Mammary Neoplasms4CTD_human
HgeneCHEK2C0085390Li-Fraumeni Syndrome2CTD_human;ORPHANET
HgeneCHEK2C0006142Malignant neoplasm of breast1UNIPROT
HgeneCHEK2C0009404Colorectal Neoplasms1CTD_human
HgeneCHEK2C0024121Lung Neoplasms1CTD_human
HgeneCHEK2C0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneCHEK2C0027819Neuroblastoma1CTD_human
HgeneCHEK2C0029463Osteosarcoma1CTD_human;HPO;ORPHANET
HgeneCHEK2C0033578Prostatic Neoplasms1CTD_human
HgeneCHEK2C0038356Stomach Neoplasms1CTD_human
HgeneCHEK2C0206720Squamous Cell Neoplasms1CTD_human
HgeneCHEK2C0242788Breast Neoplasms, Male1CTD_human
HgeneCHEK2C2931456Prostate cancer, familial1CTD_human;ORPHANET