|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 6985 |
FusionGeneSummary for CHD4_DTX1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHD4_DTX1 | Fusion gene ID: 6985 | Hgene | Tgene | Gene symbol | CHD4 | DTX1 | Gene ID | 1108 | 1840 |
| Gene name | chromodomain helicase DNA binding protein 4 | deltex E3 ubiquitin ligase 1 | |
| Synonyms | CHD-4|Mi-2b|Mi2-BETA|SIHIWES | RNF140|hDx-1 | |
| Cytomap | 12p13.31 | 12q24.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | chromodomain-helicase-DNA-binding protein 4ATP-dependent helicase CHD4Mi-2 autoantigen 218 kDa protein | E3 ubiquitin-protein ligase DTX1RING-type E3 ubiquitin transferase DTX1deltex 1, E3 ubiquitin ligasedeltex homolog 1deltex1hDTX1protein deltex-1 | |
| Modification date | 20180524 | 20180522 | |
| UniProtAcc | Q14839 | Q86Y01 | |
| Ensembl transtripts involved in fusion gene | ENST00000544484, ENST00000357008, ENST00000309577, ENST00000544040, ENST00000540960, | ENST00000257600, ENST00000547974, | |
| Fusion gene scores | * DoF score | 10 X 14 X 4=560 | 3 X 1 X 3=9 |
| # samples | 15 | 3 | |
| ** MAII score | log2(15/560*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CHD4 [Title/Abstract] AND DTX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A1-A0SK-01A | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000544484 | ENST00000257600 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| 5CDS-intron | ENST00000544484 | ENST00000547974 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| Frame-shift | ENST00000357008 | ENST00000257600 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| 5CDS-intron | ENST00000357008 | ENST00000547974 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| Frame-shift | ENST00000309577 | ENST00000257600 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| 5CDS-intron | ENST00000309577 | ENST00000547974 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| Frame-shift | ENST00000544040 | ENST00000257600 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| 5CDS-intron | ENST00000544040 | ENST00000547974 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| intron-3CDS | ENST00000540960 | ENST00000257600 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
| intron-intron | ENST00000540960 | ENST00000547974 | CHD4 | chr12 | 6690210 | - | DTX1 | chr12 | 113515229 | + |
Top |
FusionProtFeatures for CHD4_DTX1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHD4 | DTX1 |
| Component of the histone deacetylase NuRD complex whichparticipates in the remodeling of chromatin by deacetylatinghistones. {ECO:0000269|PubMed:17626165,ECO:0000269|PubMed:9804427}. | Functions as a ubiquitin ligase protein in vivo,mediating ubiquitination and promoting degradation of MEKK1,suggesting that it may regulate the Notch pathway via someubiquitin ligase activity (By similarity). Regulator of Notchsignaling, a signaling pathway involved in cell-cellcommunications that regulates a broad spectrum of cell-fatedeterminations. Mainly acts as a positive regulator of Notch, butit also acts as a negative regulator, depending on thedevelopmental and cell context. Mediates the antineural activityof Notch, possibly by inhibiting the transcriptional activationmediated by MATCH1. Involved in neurogenesis, lymphogenesis andmyogenesis, and may also be involved in MZB (Marginal zone B) celldifferentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.{ECO:0000250, ECO:0000269|PubMed:11564735,ECO:0000269|PubMed:11869684, ECO:0000269|PubMed:9590294}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CHD4_DTX1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CHD4_DTX1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CHD4 | XRN1, HDAC1, MTA2, MTA1, HDAC2, MBD3, ATR, IKZF1, IKZF3, IKZF2, IKZF4, USP36, NR4A1, BANF1, PML, NAB2, NAB1, TRIM27, SMARCA4, HNRNPC, SMARCC1, MCRS1, SRRM1, BCL11B, BCL11A, CBX5, MBD3L2, SMARCE1, SAP30, SIN3A, UBASH3B, RBBP4, RBBP7, H3F3A, PCNT, EMD, HIST1H3A, ATM, PARK7, UBC, MYC, CHD3, TAL1, BRD4, UBTF, CHD5, KPNA5, KPNA6, NOLC1, GATAD2A, GATAD2B, DPEP3, MLLT3, DPEP2, RAD21, SMARCAD1, SOX2, MTA3, RNF8, TWIST1, CBX1, CBX3, ELAVL1, SIRT7, CHD4, MCPH1, NR2C1, DNMT1, NR2C2, KDM1A, POLD3, SNAI2, SNAI1, TBL1XR1, ESR1, NOTCH1, VCAM1, CSNK2A1, HIST3H3, ITGA4, RPA1, RPA2, RPA3, LGR4, NACC2, DNMT3B, PHF6, ZFHX4, CUL7, OBSL1, CCDC8, SUZ12, EED, RNF2, BMI1, UBE2I, SUMO2, SIRT6, ZNF219, PHF20L1, ZNF524, MBD3L1, CLIP1, EIF5, EZH2, SUB1, NTRK1, HIST1H3E, CDK2AP1, ZMYND8, NFATC1, RBPJ, TEAD2, FOXE1, FOXG1, FOXJ2, FOXK2, FOXQ1, SNW1, NFATC2, PARP1, EP300, HSFY1, ZNF581, CPNE5, SNRNP27, CTBP1, NCL, MTNR1A, RUVBL2, PDHA1, FOXA1, TRIM25, MTF1, BRD1, ZNF827 | DTX1 | DTX3L, NOTCH1, DTX1, EP300, GRB2, ITCH, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2N, UBE2U, MAP3K1, EIF3F, EGR2, DEFA5, G3BP1, TAX1BP3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CHD4_DTX1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CHD4_DTX1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CHD4 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
| Hgene | CHD4 | C0036341 | Schizophrenia | 1 | CTD_human |
| Tgene | DTX1 | C0028945 | oligodendroglioma | 1 | CTD_human |
| Tgene | DTX1 | C0887833 | Carcinoma, Pancreatic Ductal | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|