FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 6936

FusionGeneSummary for CHAMP1_UNC79

check button Fusion gene summary
Fusion gene informationFusion gene name: CHAMP1_UNC79
Fusion gene ID: 6936
HgeneTgene
Gene symbol

CHAMP1

UNC79

Gene ID

283489

57578

Gene namechromosome alignment maintaining phosphoprotein 1unc-79 homolog, NALCN channel complex subunit
SynonymsC13orf8|CAMP|CHAMP|MRD40|ZNF828KIAA1409
Cytomap

13q34

14q32.12

Type of geneprotein-codingprotein-coding
Descriptionchromosome alignment-maintaining phosphoprotein 1zinc finger protein 828protein unc-79 homologunc-79 homolog
Modification date2018052320180519
UniProtAcc

Q96JM3

Q9P2D8

Ensembl transtripts involved in fusion geneENST00000361283, ENST00000478022, 
ENST00000256339, ENST00000555664, 
ENST00000553484, ENST00000393151, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 4 X 4=64
# samples 34
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHAMP1 [Title/Abstract] AND UNC79 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-56-A4ZK-01ACHAMP1chr13

115080118

+UNC79chr14

94103562

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000361283ENST00000256339CHAMP1chr13

115080118

+UNC79chr14

94103562

+
5UTR-3CDSENST00000361283ENST00000555664CHAMP1chr13

115080118

+UNC79chr14

94103562

+
5UTR-3CDSENST00000361283ENST00000553484CHAMP1chr13

115080118

+UNC79chr14

94103562

+
5UTR-3CDSENST00000361283ENST00000393151CHAMP1chr13

115080118

+UNC79chr14

94103562

+
intron-3CDSENST00000478022ENST00000256339CHAMP1chr13

115080118

+UNC79chr14

94103562

+
intron-3CDSENST00000478022ENST00000555664CHAMP1chr13

115080118

+UNC79chr14

94103562

+
intron-3CDSENST00000478022ENST00000553484CHAMP1chr13

115080118

+UNC79chr14

94103562

+
intron-3CDSENST00000478022ENST00000393151CHAMP1chr13

115080118

+UNC79chr14

94103562

+

Top

FusionProtFeatures for CHAMP1_UNC79


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHAMP1

Q96JM3

UNC79

Q9P2D8

Required for proper alignment of chromosomes atmetaphase and their accurate segregation during mitosis. Involvedin the maintenance of spindle microtubules attachment to thekinetochore during sister chromatid biorientation. May recruitCENPE and CENPF to the kinetochore. {ECO:0000269|PubMed:21063390}. Component of the NALCN sodium channel complex, a cationchannel activated either by neuropeptides substance P orneurotensin that controls neuronal excitability. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CHAMP1_UNC79


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CHAMP1_UNC79


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CHAMP1SBDS, TXLNG, TRPM8, TTC4, MDC1, CBX5, CBX8, HECW2, PIN1, HIST3H3, CBX1, POGZ, CBX3, MAD2L2, SUMO2, TMEM171, DEF6, MRE11A, RAD50, TERF2, ZMYM4, EEF1E1, GTPBP1, TBC1D4, INIP, HDGFRP2, EXOSC4, ZNF644, CDKN2AIPNL, BOP1, NFATC1, NFATC2, ZNF428, PHF19, ZNF408UNC79YWHAQ, SAE1, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CHAMP1_UNC79


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CHAMP1_UNC79


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource