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Fusion gene ID: 6933 |
FusionGeneSummary for CHAF1A_CCDC94 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CHAF1A_CCDC94 | Fusion gene ID: 6933 | Hgene | Tgene | Gene symbol | CHAF1A | CCDC94 | Gene ID | 10036 |
| Gene name | chromatin assembly factor 1 subunit A | ||
| Synonyms | CAF-1|CAF1|CAF1B|CAF1P150|P150 | ||
| Cytomap | 19p13.3 | ||
| Type of gene | protein-coding | ||
| Description | chromatin assembly factor 1 subunit ACAF-1 subunit ACAF-I 150 kDa subunitCAF-I p150CTB-50L17.7chromatin assembly factor I (150 kDa)chromatin assembly factor I p150 subunithp150 | ||
| Modification date | 20180527 | ||
| UniProtAcc | Q13111 | ||
| Ensembl transtripts involved in fusion gene | ENST00000301280, ENST00000587368, | ENST00000262962, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 4 X 5=120 |
| # samples | 1 | 6 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CHAF1A [Title/Abstract] AND CCDC94 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CHAF1A | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Hgene | CHAF1A | GO:0031497 | chromatin assembly | 8858152 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-OL-A5D7-01A | CHAF1A | chr19 | 4428887 | + | CCDC94 | chr19 | 4261991 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000301280 | ENST00000262962 | CHAF1A | chr19 | 4428887 | + | CCDC94 | chr19 | 4261991 | + |
| intron-3CDS | ENST00000587368 | ENST00000262962 | CHAF1A | chr19 | 4428887 | + | CCDC94 | chr19 | 4261991 | + |
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FusionProtFeatures for CHAF1A_CCDC94 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CHAF1A | CCDC94 |
| Core component of the CAF-1 complex, a complex thoughtto mediate chromatin assembly in DNA replication and DNA repair.Assembles histone octamers onto replicating DNA in vitro. CAF-1performs the first step of the nucleosome assembly process,bringing newly synthesized histones H3 and H4 to replicating DNA;histones H2A/H2B can bind to this chromatin precursor subsequentto DNA replication to complete the histone octamer. CHAF1A bindsto histones H3 and H4. It may play a role in heterochromatinmaintenance in proliferating cells by bringing newly synthesizedcbx proteins to heterochromatic DNA replication foci (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:15327775}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 323_453 | 534 | 957 | Compositional bias | Note=Arg/Glu/Lys-rich |
| Hgene | CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 233_246 | 534 | 957 | Motif | Note=PxVxL motif |
| Hgene | CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 1_314 | 534 | 957 | Region | Note=Binds to CBX1 chromo shadow domain |
| Hgene | CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 1_49 | 534 | 957 | Region | Note=Binds to PCNA |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 602_608 | 534 | 957 | Compositional bias | Note=Poly-Glu |
| Hgene | >CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 619_623 | 534 | 957 | Compositional bias | Note=Poly-Asp |
| Hgene | >CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 905_911 | 534 | 957 | Compositional bias | Note=Poly-Glu |
| Hgene | >CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 642_678 | 534 | 957 | Region | Note=Necessary for homodimerization and competence for chromatin assembly |
| Hgene | >CHAF1A | chr19:4428887 | chr19:4261991 | ENST00000301280 | + | 8 | 15 | 660_956 | 534 | 957 | Region | Note=Binds to p60 |
| Tgene | CCDC94 | chr19:4428887 | chr19:4261991 | ENST00000262962 | + | 4 | 8 | 105_206 | 195 | 324 | Coiled coil | Ontology_term=ECO:0000255 |
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FusionGeneSequence for CHAF1A_CCDC94 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CHAF1A_ENST00000301280_chr19_4428887_+_CCDC94_ENST00000262962_chr19_4261991_+_663aa MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTSVQSKSPDLEASLDTLENNCHVGSDIDFRPK LVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPSREAINGQREDTGDQQGLLKAIQNDKLAFPGETLSDIP CKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAGGILFKGKVPMVVLQDILAVRPPQIKSLPATPQGKNMTPESE VLESFPEEDSVLSHSSLSSPSSTSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKL KEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQ KPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNRALLEE ARKRRLLEDSDSEDEAAPSPLQPALRPNPTAILDEAPKPKRKVEVWEQSVGSLGSRPPLSRLVVVKKAKADPDCSNGQPQAAPTPGAPQN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CHAF1A_ENST00000301280_chr19_4428887_+_CCDC94_ENST00000262962_chr19_4261991_+_1989nt ATGCTGGAGGAGCTGGAGTGCGGGGCGCCCGGCGCCAGGGGAGCCGCCACAGCCATGGATTGCAAAGATAGACCAGCTTTTCCAGTTAAG AAGTTAATACAAGCCCGTCTGCCGTTTAAGCGCCTGAATCTTGTCCCAAAGGGGAAAGCCGATGACATGTCAGACGATCAGGGTACTTCT GTGCAAAGTAAAAGCCCCGATTTAGAGGCCTCTTTGGACACCTTGGAAAACAACTGTCATGTGGGTTCTGACATAGACTTTAGACCGAAA CTTGTCAACGGGAAGGGTCCCTTAGATAACTTTTTAAGAAATAGAATCGAAACCAGTATTGGCCAGAGCACAGTCATCATTGATTTGACA GAGGACTCGAATGAGCAGCCAGACAGTCTTGTGGACCACAATAAACTAAATTCTGAAGCCTCTCCCTCCAGGGAGGCAATAAATGGCCAG CGAGAAGACACTGGGGATCAGCAGGGGTTGTTGAAGGCCATTCAGAACGACAAGTTGGCATTTCCTGGAGAGACCCTTTCAGACATTCCT TGCAAAACAGAGGAGGAGGGTGTTGGCTGTGGAGGTGCAGGGAGGAGAGGCGACTCCCAGGAATGTTCGCCACGGAGCTGCCCGGAGCTG ACGAGTGGCCCGAGAATGTGCCCCAGAAAGGAGCAGGACAGTTGGAGTGAAGCTGGGGGCATCCTGTTCAAAGGGAAGGTGCCTATGGTG GTCTTGCAGGACATCTTGGCTGTGAGACCACCGCAAATCAAGTCCCTTCCAGCCACACCCCAAGGCAAGAACATGACCCCTGAGAGTGAG GTGCTGGAATCTTTCCCCGAAGAAGACTCTGTACTCAGCCATTCGTCCCTGAGCTCTCCCTCTTCCACCAGCTCGCCCGAGGGGCCGCCT GCTCCCCCAAAGCAGCACAGCAGTACCAGTCCCTTCCCCACCTCCACGCCCCTCCGCAGAATAACTAAGAAATTCGTCAAAGGCTCTACA GAGAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAAAGGAGAAGCTG AAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGCGGGAGAAGCGG GAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGGCTAAACTTGAG GAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGAGGTTCTTCCAG AAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACATGGTCCTGGCC CCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCTCCTTCTTGAAA GACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGGGCCCTGTTGGAGGAA GCCAGAAAGCGAAGACTGCTGGAGGACTCCGACTCAGAGGATGAGGCTGCTCCCTCGCCCCTGCAGCCAGCCCTTCGGCCCAACCCCACC GCCATCCTGGATGAGGCCCCAAAGCCCAAGAGGAAGGTGGAGGTCTGGGAGCAGAGCGTTGGCAGCCTGGGCAGCCGGCCCCCGCTGTCG AGGCTGGTCGTGGTGAAGAAGGCAAAGGCCGACCCGGACTGCAGCAACGGGCAGCCTCAGGCGGCCCCCACCCCAGGAGCCCCGCAGAAC AGGAAGGAGGCCAACCCTACACCCCTGACGCCTGGCGCGTCCTCCCTGAGCCAACTGGGTGCATACCTGGACAGTGACGACAGCAACGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CHAF1A_ENST00000301280_chr19_4428887_+_CCDC94_ENST00000262962_chr19_4261991_+_2484nt GGCGGCAGCAGCGGCGCGGGCGGGAGGGCGAAGAGCAGCGGCCGCCTGAGGGGAGCCCGCGCCTCCGCCGCCTGAGAGGAGGTCGAGCTG CCGCCGGGGCGATGCTGGAGGAGCTGGAGTGCGGGGCGCCCGGCGCCAGGGGAGCCGCCACAGCCATGGATTGCAAAGATAGACCAGCTT TTCCAGTTAAGAAGTTAATACAAGCCCGTCTGCCGTTTAAGCGCCTGAATCTTGTCCCAAAGGGGAAAGCCGATGACATGTCAGACGATC AGGGTACTTCTGTGCAAAGTAAAAGCCCCGATTTAGAGGCCTCTTTGGACACCTTGGAAAACAACTGTCATGTGGGTTCTGACATAGACT TTAGACCGAAACTTGTCAACGGGAAGGGTCCCTTAGATAACTTTTTAAGAAATAGAATCGAAACCAGTATTGGCCAGAGCACAGTCATCA TTGATTTGACAGAGGACTCGAATGAGCAGCCAGACAGTCTTGTGGACCACAATAAACTAAATTCTGAAGCCTCTCCCTCCAGGGAGGCAA TAAATGGCCAGCGAGAAGACACTGGGGATCAGCAGGGGTTGTTGAAGGCCATTCAGAACGACAAGTTGGCATTTCCTGGAGAGACCCTTT CAGACATTCCTTGCAAAACAGAGGAGGAGGGTGTTGGCTGTGGAGGTGCAGGGAGGAGAGGCGACTCCCAGGAATGTTCGCCACGGAGCT GCCCGGAGCTGACGAGTGGCCCGAGAATGTGCCCCAGAAAGGAGCAGGACAGTTGGAGTGAAGCTGGGGGCATCCTGTTCAAAGGGAAGG TGCCTATGGTGGTCTTGCAGGACATCTTGGCTGTGAGACCACCGCAAATCAAGTCCCTTCCAGCCACACCCCAAGGCAAGAACATGACCC CTGAGAGTGAGGTGCTGGAATCTTTCCCCGAAGAAGACTCTGTACTCAGCCATTCGTCCCTGAGCTCTCCCTCTTCCACCAGCTCGCCCG AGGGGCCGCCTGCTCCCCCAAAGCAGCACAGCAGTACCAGTCCCTTCCCCACCTCCACGCCCCTCCGCAGAATAACTAAGAAATTCGTCA AAGGCTCTACAGAGAAGAACAAGCTCAGACTGCAAAGAGATCAGGAGCGTCTGGGCAAGCAGCTCAAGTTACGTGCAGAAAGGGAAGAAA AGGAGAAGCTGAAAGAGGAGGCCAAGCGGGCCAAGGAGGAGGCCAAGAAGAAGAAGGAGGAAGAGAAGGAGCTTAAGGAAAAGGAGAGGC GGGAGAAGCGGGAGAAGGATGAGAAGGAGAAGGCGGAGAAGCAGCGGCTCAAGGAGGAGCGGCGCAAGGAGAGACAGGAAGCCCTGGAGG CTAAACTTGAGGAAAAAAGGAAAAAGGAAGAAGAGAAACGGTTAAGAGAAGAAGAGAAGCGCATTAAAGCAGAGAAGGCCGAAATCACGA GGTTCTTCCAGAAACCAAAGACTCCACAGGCCCCCAAGACCCTGGCCGGCTCCTGTGGGAAGTTTGCCCCCTTTGAAATTAAAGAGCACA TGGTCCTGGCCCCTCGGCGTCGGACCGCTTTCCATCCAGACCTCTGCAGTCAGCTGGACCAGCTCCTCCAGCAGCAGAGCGGCGAGTTCT CCTTCTTGAAAGACCTCAAAGGCCGGCAGCCCCTGAGGTCCGGACCCACGCACGTTTCCACCCGGAATGCAGATATTTTTAACAGGGCCC TGTTGGAGGAAGCCAGAAAGCGAAGACTGCTGGAGGACTCCGACTCAGAGGATGAGGCTGCTCCCTCGCCCCTGCAGCCAGCCCTTCGGC CCAACCCCACCGCCATCCTGGATGAGGCCCCAAAGCCCAAGAGGAAGGTGGAGGTCTGGGAGCAGAGCGTTGGCAGCCTGGGCAGCCGGC CCCCGCTGTCGAGGCTGGTCGTGGTGAAGAAGGCAAAGGCCGACCCGGACTGCAGCAACGGGCAGCCTCAGGCGGCCCCCACCCCAGGAG CCCCGCAGAACAGGAAGGAGGCCAACCCTACACCCCTGACGCCTGGCGCGTCCTCCCTGAGCCAACTGGGTGCATACCTGGACAGTGACG ACAGCAACGGCAGCAACTGAGCCCTCCCAGGACCCCCTCACGGGGTCAAAGTCACACGTCCAGCTTCAGCCACATTGAGGCCAGCATTGC TGGTGGTCAGGGCAGGAGGCCTTGGCGTGACTGGAGGCCGGACAGACAAGCGCCAGCGTGCTCCAACACATAGGGCCACCAGGGGCCTCA GCCCCAGGAGGTCCCTTCTCTGTGCCCTCACCAGCCTCTCAACACCTCGGGGACCCCTGCTGCTCCTGCCCCCACCTGTCACTGTGCTTA GGGCTGCAACATCCCTGGAGCAGCTTCCAACACTACTTCAGGGTGGCAGTGTTTGGGGCACTGGGCGAGCCTGCCGGCCTCTAGATGGCC |
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FusionGenePPI for CHAF1A_CCDC94 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CHAF1A | MBD1, ASF1B, BLM, CBX5, TCERG1, CHAF1B, PCNA, ASF1A, SUMO2, SUMO3, SUMO1, WRN, YWHAE, YWHAG, YWHAZ, DMAP1, RPA1, XPC, LZTR1, RBFOX2, PCBD2, SETDB1, CHAF1A, CDC7, CDK2, HIST1H3A, ANP32A, ANP32B, DDX41, EIF3C, GTF2I, HMGB2, NONO, PAF1, PRKDC, PRPF31, RBM3, RPS3, RPS9, SET, XRCC5, YWHAB, XRCC6, YWHAQ, HIST1H3E, MSH6, HIST4H4, CBX1, HIST1H4F, HIST2H3C, PABPC1, TOB1, TOB2, GFI1, HIST1H3B, CNOT6L, CNOT6, H3F3A, SQSTM1, RBBP4, CBX3, ZNF408, BECN1, ATG14, REL, TCF4, HIST3H3, NUSAP1, TCEB3, EWSR1, PIK3R1, TIGD6, TEAD2, HIST1H4A, P4HA3 | CCDC94 | GOLGA2, TRIM27, TFCP2, MAD1L1, JADE1, CEP70, NPDC1, OR7C1, PRPF19, XAB2, GPATCH1, TRIM62, CRNKL1, PLRG1, CDC5L, WDR83, SETMAR, SERPINB4, SNW1, BCAS2, CCDC12, TYMP, HIF1AN, ISY1, DHX35, SYF2, AQR, CALML3, CALML5, EIF4EBP1, HIST1H2BG, CLCN2, KIF20B, TOMM40, SEC13, DIS3, PPIE |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CHAF1A_CCDC94 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CHAF1A_CCDC94 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CHAF1A | C0026636 | Mouth Diseases | 1 | CTD_human |
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