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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 692

FusionGeneSummary for ADAM15_DCST1

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAM15_DCST1
Fusion gene ID: 692
HgeneTgene
Gene symbol

ADAM15

DCST1

Gene ID

8751

149095

Gene nameADAM metallopeptidase domain 15DC-STAMP domain containing 1
SynonymsMDC15-
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptiondisintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15E3 ubiquitin-protein ligase DCST1DC-STAMP domain-containing protein 1RING-type E3 ubiquitin transferase
Modification date2018052220180519
UniProtAcc

Q13444

Q5T197

Ensembl transtripts involved in fusion geneENST00000449910, ENST00000368412, 
ENST00000359280, ENST00000356955, 
ENST00000355956, ENST00000360674, 
ENST00000368410, ENST00000271836, 
ENST00000368413, ENST00000531455, 
ENST00000447332, ENST00000472434, 
ENST00000392480, ENST00000295542, 
ENST00000423025, ENST00000368419, 
Fusion gene scores* DoF score2 X 2 X 3=121 X 1 X 2=2
# samples 32
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/2*10)=3.32192809488736
Context

PubMed: ADAM15 [Title/Abstract] AND DCST1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAM15

GO:0002418

immune response to tumor cell

22505472

HgeneADAM15

GO:0006915

apoptotic process

22505472

HgeneADAM15

GO:0045087

innate immune response

22505472

HgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-AS-3777-01AADAM15chr1

155025253

+DCST1chr1

155006448

+
TCGARVLIHCTCGA-DD-A115-01AADAM15chr1

155025253

+DCST1chr1

155006448

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000449910ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000449910ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000449910ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000449910ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368412ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368412ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368412ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368412ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000359280ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000359280ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000359280ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000359280ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000356955ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000356955ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000356955ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000356955ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000355956ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000355956ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000355956ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000355956ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000360674ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000360674ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000360674ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000360674ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368410ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368410ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368410ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368410ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000271836ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000271836ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000271836ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000271836ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368413ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368413ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368413ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000368413ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000531455ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000531455ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000531455ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000531455ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000447332ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000447332ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000447332ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
5CDS-5UTRENST00000447332ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+
3UTR-5UTRENST00000472434ENST00000392480ADAM15chr1

155025253

+DCST1chr1

155006448

+
3UTR-5UTRENST00000472434ENST00000295542ADAM15chr1

155025253

+DCST1chr1

155006448

+
3UTR-5UTRENST00000472434ENST00000423025ADAM15chr1

155025253

+DCST1chr1

155006448

+
3UTR-5UTRENST00000472434ENST00000368419ADAM15chr1

155025253

+DCST1chr1

155006448

+

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FusionProtFeatures for ADAM15_DCST1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAM15

Q13444

DCST1

Q5T197

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomaldegradation thereby negatively regulating type-I-interferonsignaling. {ECO:0000269|PubMed:27782195}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAM15_DCST1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAM15_DCST1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAM15SNX9, TRIP13, MAD2L2, SH3GL2, FYN, LCK, GRB2, MAD2L1, HCK, SRC, SNX30, NPHP1, ARHGEF7, LYN, YES1, SH3PXD2A, PACSIN3, SH3GLB1, ARHGEF6, NCK1, SORBS2, SH3RF3, MAPK3, MAPK1, PTK6, FBXO6, FHL3, SP4, RBPMS, NUP62, BANP, ADAM33, TRIM25DCST1CUL4A, NEDD1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAM15_DCST1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAM15_DCST1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource